Effects of bee venom on the pro-inflammatory responses in RAW264.7 macrophage cell line

Bee venom suppresses PMA-mediated MMP-9 gene activation via JNK/p38 and NF-κB-dependent mechanisms

“…It is composed of various peptide and non-peptide components with the peptides composed mainly of apamin, melittin and PLA 2 (Jang et al, 2005). The non-peptide components consist of histamine, dopamine and noradrenalin (Lee et al, 2001).…”

“…The various components of bee venom have been previously described and is mostly composed of apamin (Son et al, 2007), melittin, PLA 2 (Jang et al, 2005), adolapin and mast cell-degranulating peptide (MCCP) with melittin being the major component (Son et al, 2007). We analyzed inhibitory effects of three individual bee venom component, melittin, apamin and PLA 2, on MMP-9.…”

Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia

“…Recent reports have indicated that acupuncture and administration of BV can significantly impart an antiarthritic response mediated by inhibition of inflammation mediators, similar to non-steroidal anti-inflammatory drugs [8,9]. Jang and his colleagues reported that BV has anti-inflammatory effects in Raw264.7 macrophage cell line which is ascribed to only transcriptional downregulation of iNOS, COX-2, nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) [10]. Our previous study also showed that BV induces apoptosis in human leukemic U937 cells through the modulation of caspase-3 and Bcl-2 [11].…”

Effect of honey bee venom on microglial cells nitric oxide and tumor necrosis factor-α production stimulated by LPS

“…Each honey bee venom substance has been studied to elucidate their anti-inflammatory effects (Somerfield et al, 1984;Saini et al, 1997). Honey bee venom was proven to have anti-inflammatory properties by inhibiting iNOS and COX-e expression possibly through the suppression of NF-B and MARK activities (Jang et al, 2005).…”