Effects of benfotiamine on the insulin resistance state, some pro- and anti-inflammatory factors content in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy

Serhiyenko, Victoria; Serhiyenko, Alexandr; Segin, Volodymyr; Azhmi, S.; Serhiyenko, Ludmila

doi:10.15829/1560-4071-2019-4-78-82

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…This might improve the growth performance of fish. Additionally, benfotiamine administration has been demonstrated to reduce hyperglycaemia‐induced the metabolic damages in mammals by the inhibition of inflammation (Hammes et al, 2003; Serhiyenko et al, 2019). It is possible that a similar mechanism also exists in fish.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it also has potent antioxidant, anti‐inflammatory, anti‐apoptotic and anti‐carcinogenic properties (Beltramo et al, 2008; Tapias et al, 2018). In the study of diabetes, benfotiamine has been shown to prevent β‐cell dysfunction by inhibiting inflammation, thereby improving insulin resistance in tissues (Serhiyenko et al, 2019). However, literature regarding the influences of this substance on aquatic animals is extremely scarce.…”

Section: Introductionmentioning

confidence: 99%

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Benfotiamine ameliorates high‐carbohydrate diet‐induced hepatic oxidative stress, inflammation and apoptosis in Megalobrama amblycephala

Liu

Shi

et al. 2021

Aquaculture Research

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A 12‐week nutritional research was conducted to evaluate the influences of benfotiamine on the growth performance, oxidative stress, inflammation and apoptosis in Megalobrama amblycephala (45.25 ± 0.34 g) fed high‐carbohydrate (HC) diets. Six diets were prepared, containing the control diet (30% carbohydrate, C), the HC diet (43% carbohydrate) and the HC diet supplemented with four benfotiamine levels (0.7125 (HCB1), 1.425 (HCB2), 2.85 (HCB3) and 5.7 (HCB4) mg/kg). HC diet remarkably decreased DGC, GRMBW, liver T‐AOC, SOD and CAT activities, SIRT1 protein expression as well as the mRNA levels of SIRT1, Nrf2, CAT, Mn‐SOD and IL10 in liver compared with the C group, but the opposite trend was found in plasma activities of AST and ALT, and contents of IL1β and IL6, liver contents of MDA and mRNA levels of Keap1, NF‐κB, TNF α, IL1β, IL6, Bax, caspase 3, caspase 9 and P53. As for benfotiamine supplementation, HCB2 diet remarkably increased DGC, GRMBW, liver T‐AOC, SOD and CAT activities, SIRT1 protein expression as well as liver mRNA levels of SIRT1, Nrf2, CAT, Mn‐SOD, IL10 and Bcl2, while the opposite was true for plasma AST and ALT activities, and IL1β and IL6 contents, liver MDA contents as well as mRNA levels of Keap1, NF‐κB, TNF α, IL1β, IL6, Bax, caspase 3, caspase 9 and P53. In summary, benfotiamine (1.425 mg/kg) promoted the growth, and alleviated the oxidative stress, inflammation and apoptosis of M. amblycephala fed HC diets through the SIRT1‐mediated signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Benfotiamine ameliorates high‐carbohydrate diet‐induced hepatic oxidative stress, inflammation and apoptosis in Megalobrama amblycephala

Liu

Shi

et al. 2021

Aquaculture Research

View full text Add to dashboard Cite

show abstract

“…This might improves the growth performance of sh. Additionally, benfotiamine administration has been demonstrated to reduce the metabolic damage induced by hyperglycemia in mammals by the inhibition of in ammation, and the decrease of advanced glycation end products (AGEs) formation [24,27]. This is possible that a similar mechanism exists in sh.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it also has potent anti-oxidant, anti-in ammatory, anti-apoptotic and anti-carcinogenic properties [25,26]. In the study of diabetes, benfotiamine has been shown to prevent β-cell dysfunction by inhibiting in ammation, thereby improving insulin resistance in tissues [27]. However, information regarding the effects of this substance on aquatic animals is extremely scarce.…”

Section: Introductionmentioning

confidence: 99%

Benfotiamine Ameliorates High Carbohydrate Diet-Induced Hepatic Oxidative Stress, Inflammation and Apoptosis in Megalobrama Amblycephala

Liu

Shi

et al. 2020

Preprint

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Background: The impairment of immunity induced by high-carbohydrate diet is closely associated with the development of glucose metabolic disorders. In the study of diabetes, benfotiamine can prevent β-cell dysfunction by inhibiting inflammation, thereby improving insulin resistance. However, information regarding the effects of this substance on aquatic animals is extremely scarce.Methods: A 12-week nutritional research was conducted to evaluate the influences of benfotiamine on the growth performance, oxidative stress, inflammation and apoptosis in Megalobrama amblycephala (45.25 ± 0.34 g) fed high-carbohydrate (HC) diets. Six experimental diets were formulated, containing a control diet (30% carbohydrate, C), a HC diet (43% carbohydrate), and the HC diet supplemented with four graded benfotiamine levels (0.7125 (HCB1), 1.425 (HCB2), 2.85 (HCB3), and 5.7 (HCB4) mg/kg).Results: HC diet intake remarkably decreased daily growth coefficient (DGC), growth rate per metabolic body weight (GRMBW), feed intake (FI), liver antioxidant enzymes activities, sirtuin-1 (SIRT1) protein expression as well as liver mRNA levels of SIRT1, nuclear factor erythroid 2-related factor 2 (Nrf2), catalase (CAT), manganese superoxide dismutase (Mn-SOD), interleukin10 (IL10) than those of the control group, but the opposite was true for plasma activities of alanine transaminase (AST) and aspartate aminotransferase (ALT), and contents of interleukin 1β (IL1β) and interleukin 6 (IL6), liver contents of malondialdehyde (MDA), and mRNA levels of kelch-like ECH associating protein 1 (Keap1), nuclear factor kappa B (NF-κB), tumour necrosis factor α (TNF α), IL1β, IL6, Bax, Caspase 3, Caspase 9 and P53. As with benfotiamine supplementation, HCB2 diet remarkably increased DGC, GRMBW, liver antioxidant enzymes activities, SIRT1 protein expression as well as liver mRNA levels of SIRT1, Nrf2, CAT, Mn-SOD, IL10 and Bcl2, while the opposite was true for plasma activities of AST and ALT, and contents of IL1β and IL6, liver MDA contents as well as mRNA levels of Keap1, NF-κB, TNF α, IL1β, IL6, Bax, Caspase 3, Caspase 9 and P53.Conclusion: Benfotiamine at 1.425 mg/kg can improve the growth performance and alleviate the oxidative stress, inflammation and apoptosis of M. amblycephala fed HC diets through the activation of the SIRT1 pathway.

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Effects of benfotiamine on the insulin resistance state, some pro- and anti-inflammatory factors content in patients with type 2 diabetes mellitus and cardiac autonomic neuropathy

Cited by 2 publications

References 14 publications

Benfotiamine ameliorates high‐carbohydrate diet‐induced hepatic oxidative stress, inflammation and apoptosis in Megalobrama amblycephala

Benfotiamine ameliorates high‐carbohydrate diet‐induced hepatic oxidative stress, inflammation and apoptosis in Megalobrama amblycephala

Benfotiamine Ameliorates High Carbohydrate Diet-Induced Hepatic Oxidative Stress, Inflammation and Apoptosis in Megalobrama Amblycephala

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