Effects of Bicarbonate Removal on the Spontaneous Mechanical Activity of the Guinea Pig Uterus

In guinea pig isolated uterine strips, separate addition of adenosine, adenine and NAD was without any effect. Adenosine and NAD when administered after previously applied subthreshold dose of PGE2 exhibited a strong contractile effect. Indomethacin, added to the organ bath before addition of prostaglandin, blocked, partially or totally, the observed synergistic action of PGE2 with adenosine and NAD. From the experimental data of the present work it is postulated that adenosine and NAD stimulate prostaglandin biosynthesis in myometrium as already it has been suggested for ATP, ADP and AMP. The aspect for the existence of a functional link between adenyl compounds and prostaglandins, based on these findings, is reinforced.

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Effects of Bicarbonate Removal on the Spontaneous Mechanical Activity of the Guinea Pig Uterus

Cited by 2 publications

References 13 publications

The effect of PGE2 and PGF2α on the response of guinea pig myometrium to adenine nucleotides in vitro

The effect of PGE2 and PGF2α on the response of guinea pig myometrium to adenine nucleotides in vitro

Studiesin vitroon the Effect of Adenosine, Adenine and Nad on Guinea Pig Myometrium in the Presence of Exogenously Applied Pge₂

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Effects of Bicarbonate Removal on the Spontaneous Mechanical Activity of the Guinea Pig Uterus

Cited by 2 publications

References 13 publications

The effect of PGE2 and PGF2α on the response of guinea pig myometrium to adenine nucleotides in vitro

The effect of PGE2 and PGF2α on the response of guinea pig myometrium to adenine nucleotides in vitro

Studiesin vitroon the Effect of Adenosine, Adenine and Nad on Guinea Pig Myometrium in the Presence of Exogenously Applied Pge2

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Product

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Studiesin vitroon the Effect of Adenosine, Adenine and Nad on Guinea Pig Myometrium in the Presence of Exogenously Applied Pge₂