Effects of Bifemelane on Incomplete Cerebral Ischaemia‐Induced Reduction of Long‐Term Potentiation in Rat Hippocampal Neurones in vivo

Abstract

Abstract:In the present study, we investigated the effects of bifemelane on the reduction of hippocampal long-term potentiation after transient ischaemia. Bilateral common carotid arteries were clamped for 10 min. in halothane-anaesthetized rats. Thirty min. before occlusion, bifemelane (25 mg/kg, intraperitoneally) or saline was administered to the rats. Four days after occlusion, we measured long-term potentiation in Schaffer collateral-CAl synapses and perforant pathdentate gyrus synapses in v i v a Long-term potentiation was significantly reduced in both the Schaffer collateral-CAl and perforant path-dentate gyrus synapses in the saline-injected group. However bifemelane decreased the ischaemia-induced reduction of long-term potentiation in perforant path-dentate gyrus synapses, but not in Schaffer collateral-CAl synapses. The findings suggest that bifemelane deserves further attention with regard to possible protective role in ischaemia.

Effects of propofol and halothane on long-term potentiation in the rat hippocampus after transient cerebral ischaemia

“…The hippocampus is well known to be one of the most vulnerable brain regions to ischaemia. Previous reports have shown that hippocamal LTP formation is significantly impaired by incomplete cerebral ischaemia and is accompanied by no histological change and that it can be rescued by pharmacological interventions including brain metabolic stimulants and a radical scavenger [16][17][18].…”