Effects of biguanides on oxidative status of rat tissues after cerebral ischemia/reperfusion

Сафонова, О. А.; Попова, Т. Н.; Макеева, А. В.; Панченко, Л. Ф.

doi:10.1134/s1819712409040096

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2011

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“…Alongside with reduction in reduced glutathione requirements, activity of GR involved in redox-cycle of this compound was also reduced. It can be hypothesized that 2,4-dimethoxyphenyl biguanide reduced the strain of the glutathione system during oxidative stress induced by ischemiareperfusion via inhibition of free-radical reaction [7].…”

Section: Resultsmentioning

confidence: 99%

Effects of 2,4-Dimethoxyphenyl Biguanide on Glutathione System Activity in Rat Tissues in Brain Ischemia–Reperfusion

2011

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We studied the effects of dimethoxyphenyl biguanide on glutathione peroxidase and glutathione reductase activities, level of reduced glutathione in rat tissues, and activity of some NADPH-regenerating enzymes (glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase) under conditions of ischemia-reperfusion of the brain. Administration of this biguanide derivative under pathological conditions led to a decrease in the analyzed parameters (elevated under conditions of ischemia-reperfusion) in the serum and brain tissue. The results attest to less pronounced mobilization of the glutathione system (compared to pathological state) due to antioxidant and protective properties of 2,4-dimethoxyphenyl biguanide under conditions of ischemic tissue damage associated with oxidative stress.

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Section: Resultsmentioning

confidence: 99%