Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

Abstract

Lung carcinoma is one of the most common cancers and has a high mortality.Recently, we showed that it produces neurological paraneoplastic syndrome, with Ilex paraguariensis (IP) extract exerting palliative effects due to its content of phenolic compounds. It is possible, therefore, that these diet agents can arrive at the brain and exert neuroprotection, after the oral intake of IP. Here, the aim was to investigate the protective role of bioavailable IP compounds on the telencephalon and diencephalon in lung adenocarcinoma-bearing BALB/cJ males. Mice aged 2 months were treated for 3 weeks with 0-100 IP mg·kg −1 ·day −1 . HPLC-UV revealed the presence of chlorogenic acid and quercetin in brain regions, liver, and tumour, in an IP dosedependent manner. Brain was also evaluated histologically, and interleukin-6 was measured by ELISA. Chlorogenic acid was the major compound found in brain, whereas quercetin was observed at the diencephalon to a lesser extent. Both compounds were involved in IP dose-dependent diencephalic interleukin-6 reduction. Histology suggested cellular protection with less apoptosis in chlorogenic-exposed areas.Taken together, chlorogenic acid and quercetin from dietary IP were bioavailable and bioactive in brain, thereby attenuating lung cancer-related neuroinflammation and damage. These findings support plant-based strategies to improve prognosis. KEYWORDS chlorogenic acid, high performance liquid chromatography, interleukin-6, paraneoplastic syndrome, quercetin

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

“…In hypoxia-induced injury of pheochromocytoma (PC-12) cells, quercetin was found to be effective by activating AMPK and Wnt/β-catenin signaling pathways via down-regulation of miR-122 as reported by Yan et al [134]. Quercetin was reported to be found in the brain and other organs, including tumors induced in mice for studying the intake of Ilex paraguariensis A. St.-Hil [135]. They hypothesized that quercetin and chlorogenic acid present in Ilex paraguariensis A. St.-Hil, if taken in diet, can reduce lung cancer-related neuroinflammation.…”

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

“…It also has properties to treat dementia. More recently, several groups of researchers have demonstrated that I. paraguariensis derivatives are abundant with bioactive compounds which when enters CNS and produces significant therapeutic indices( Cittadini et al, 2019 ). Leaves aqueous extract of this medicinal herb has been shown to potentially inhibit scopolamine-induced memory loss in male Swiss mice ( Santos et al, 2015 ).…”

Yerba mate: cultivation systems, processing and chemical composition. A review

“…In vivo studies show that infusion could inhibit oxidation of LDL (low density lipoprotein), also contributing to treatments of obesity, diabetes, and arteriosclerosis (Godoy et al, 2013;Habtemariam, 2019;Luís et al, 2019). Recent research has shown numerous therapeutic qualities of yerba mate, including hepatoprotective, neuroprotective, resistance against oxidative stress, antiobesity, cardioprotection, and antioxidant effects ( Figure 5) (Baeza et al, 2017;Cahuê et al, 2019;Cittadini et al, 2019b;Panza et al, 2018;Valenca et al, 2019).…”