Effects of biodegradable biomedical porous MnO2 nanoparticles on blood components and functions

Lin, Jiansheng; Song, Ting; Liu, Zonghua; Yang, Deguang; Xiang, Rong; Hua, Wenxi; Wan, Huaibin

doi:10.1016/j.colsurfb.2022.112667

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…MnO 2 nanomaterials have been reported to show excellent physical, chemical and biological properties, such as high specific surface area, high adsorption, strong oxidation, high catalytic activity, broad spectrum light absorption range, strong fluorescence quenching, good degradability and biosafety, etc ( 49 – 51 ). There are two widely known mechanisms for MnO 2 nanomaterials to excute their functions in biological systems: the redox reaction between MnO 2 and glutathione (GSH) ( 52 ), and the catalytic reactions of MnO 2 nanomaterials to decompose H 2 O 2 into O 2 under acidic conditions ( 53 ).…”

Section: Medical Application Of Mno 2 Nanomaterialsmentioning

confidence: 99%

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Zhang

et al. 2023

Front. Immunol.

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As an essential micronutrient, manganese plays an important role in the physiological process and immune process. In recent decades, cGAS-STING pathway, which can congenitally recognize exogenous and endogenous DNA for activation, has been widely reported to play critical roles in the innate immunity against some important diseases, such as infections and tumor. Manganese ion (Mn2+) has been recently proved to specifically bind with cGAS and activate cGAS-STING pathway as a potential cGAS agonist, however, is significantly restricted by the low stability of Mn2+ for further medical application. As one of the most stable forms of manganese, manganese dioxide (MnO2) nanomaterials have been reported to show multiple promising functions, such as drug delivery, anti-tumor and anti-infection activities. More importantly, MnO2 nanomaterials are also found to be a potential candidate as cGAS agonist by transforming into Mn2+, which indicates their potential for cGAS-STING regulations in different diseased conditions. In this review, we introduced the methods for the preparation of MnO2 nanomaterials as well as their biological activities. Moreover, we emphatically introduced the cGAS-STING pathway and discussed the detailed mechanisms of MnO2 nanomaterials for cGAS activation by converting into Mn2+. And we also discussed the application of MnO2 nanomaterials for disease treatment by regulating cGAS-STING pathway, which might benefit the future development of novel cGAS-STING targeted treatments based on MnO2 nanoplatforms.

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Section: Medical Application Of Mno 2 Nanomaterialsmentioning

confidence: 99%

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Zhang

et al. 2023

Front. Immunol.

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“…MnO2NPs have great clinical translation potential. However, by contrast, the in vitro and in-vivo bio-safeties of MnO 2 NPs have been deeply and thoroughly clarified for clinical translation, which hinders their clinical applications [ 11 ]. Because of the number of benefits, MnO 2 NPs are one of the best options.…”

Section: Introductionmentioning

confidence: 99%

Potential in-vitro antioxidant and anti-inflammatory activity of Martynia annua extract mediated Phytosynthesis of MnO2 nanoparticles

Thangapushbam,

Rama,

Sivakami

et al. 2024

Heliyon

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“…Moreover, manganese oxide is regarded as an efficient chemical in medicine and healthcare. Jiansheng Lin et al have investigated the biomedical development of porous manganese dioxide nanoparticles (MnO 2 NPs) on the microstructure of red blood cells and functions [ 16 ]. Despite these advantages, manganese oxide has a few drawbacks, such as weak electrical behavior and wide band gap.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the Morphological Architecture of Mn2O3 Nanoparticles to MnCoO Nanoflakes by Loading Co3+ Via a Co-Precipitation Approach for Mosquitocidal Development

et al. 2023

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The spread of many infectious diseases by vectors is a globally severe issue. Climate change and the increase of vector resistance are the primary sources of rising mosquito populations. Therefore, advanced approaches are needed to prevent the dispersal of life-threatening diseases. Herein, Mn2O3 NPs and MnCoO nanocomposites were presented as mosquitocidal agents. The synthesized samples were prepared by a co-precipitation route and characterized using different techniques indicating the change of host Mn2O3 structure to 2D MnCoO nanoflakes with Co3+ integration. The thermal decomposition of the nanoparticles was examined by TGA analysis, showing high stability. The energy gap () of Mn2O3 was estimated within the visible spectrum of the value 2.95 eV, which reduced to 2.80 eV with doping support. The impact of Mn2O3 and MnCoO on immature stages was investigated by semithin photomicrographs exhibiting significant changes in the midgut, fat tissue and muscles of the third larval instar. Moreover, the external deformations in pupae were examined using scanning electron microscopy (SEM).

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Effects of biodegradable biomedical porous MnO2 nanoparticles on blood components and functions

Cited by 7 publications

References 33 publications

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Advances of MnO2 nanomaterials as novel agonists for the development of cGAS-STING-mediated therapeutics

Potential in-vitro antioxidant and anti-inflammatory activity of Martynia annua extract mediated Phytosynthesis of MnO2 nanoparticles

Modulation of the Morphological Architecture of Mn2O3 Nanoparticles to MnCoO Nanoflakes by Loading Co3+ Via a Co-Precipitation Approach for Mosquitocidal Development

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