Effects of biogenic synthesis of chitosan entrapped silver nanoparticle from Aegle marmelos on human cervical cancer cells (HeLa)

Sukumar, D; Gunasangkaran, Gayathiri; Arumugam, Vijaya Anand; Muthukrishnan, Saradhadevi

doi:10.1016/j.jddst.2022.103189

Cited by 14 publications

(6 citation statements)

References 40 publications

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“…CS/Ag NPs induced a 50% growth defeat property at a concentration of 34.5 ± 0.5 µg/mL. Similarly, Murugesan et al [ 47 ] reported that the synthesized Ag NPs using Gloriosa superba exhibited potential anticancer activity against A549 cells. Similar findings were reported by Priya et al [ 59 ], who observed the dose-dependent anticancer activity of biogenic CS-Ag NPs against hepatocellular carcinoma cells.…”

Section: Resultsmentioning

confidence: 96%

“…According to reports, the UV absorbance peak around 400–480 nm was a distinct property of nano-Ag [ 46 ]. Similarly, CS- Aegle marmelos entrapped Ag NPs exhibited UV-vis absorbance at 420 nm [ 47 ]. The UV-visible spectrum of CS-decorated Ag NPs was prepared using Piper betle exhibited an absorption peak at 430 nm [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Similar findings were reported by Priya et al [ 59 ], who observed the dose-dependent anticancer activity of biogenic CS-Ag NPs against hepatocellular carcinoma cells. The biogenic synthesized Ag NPs entrapped with CS showed anticancer activity against HeLa cells [ 47 ]. It was reported that the anticancer properties of Ag NPs were dependent on the morphology, size, and reducing agents of the NPs.…”

Section: Resultsmentioning

confidence: 99%

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Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

et al. 2023

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In the treatment of bacterial contamination, the problem of multi-drug resistance is becoming an increasingly pressing concern. Nanotechnology advancements enable the preparation of metal nanoparticles that can be assembled into complex systems to control bacterial and tumor cell growth. The current work investigates the green production of chitosan functionalized silver nanoparticles (CS/Ag NPs) using Sida acuta and their inhibition efficacy against bacterial pathogens and lung cancer cells (A549). Initially, a brown color formation confirmed the synthesis, and the chemical nature of the synthesized NPs were examined by UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). FTIR demonstrated the occurrence of CS and S. acuta functional groups in the synthesized CS/Ag NPs. The electron microscopy study exhibited CS/Ag NPs with a spherical morphology and size ranges of 6–45 nm, while XRD analysis demonstrated the crystallinity of Ag NPs. Further, the bacterial inhibition property of CS/Ag NPs was examined against K. pneumoniae and S. aureus, which showed clear inhibition zones at different concentrations. In addition, the antibacterial properties were further confirmed by a fluorescent AO/EtBr staining technique. Furthermore, prepared CS/Ag NPs exhibited a potential anti-cancer character against a human lung cancer cell line (A549). In conclusion, our findings revealed that the produced CS/Ag NPs could be used as an excellent inhibitory material in industrial and clinical sectors.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

et al. 2023

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“…Due to its distinctive qualities, which include tissue regeneration acceleration, blood coagulation stimulation, increased rate of O2 transmission, microbial prevention, and epithelization acceleration, it is a helpful biomaterial for wound healing [14,15] . Chitosan can also be cross‐linked with glyoxal, glutaraldehyde, and terephthaldehyde to create biomaterials that can be applied to various biological applications, including gene delivery, therapy, and organ transplantation [16] . Chitosan is the most often employed biopolymer for the creation of nanoparticles because of its distinct features.…”

Section: Introductionmentioning

confidence: 99%

“…[14,15] Chitosan can also be cross-linked with glyoxal, glutaraldehyde, and terephthaldehyde to create biomaterials that can be applied to various biological applications, including gene delivery, therapy, and organ transplantation. [16] Chitosan is the most often employed biopolymer for the creation of nanoparticles because of its distinct features. Kolanthai et al, prepared a scaffold from GO-CS-Alginate-Collagen for tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Improving the Durability of Chitosan Films through Incorporation of Magnesium, Tungsten, and Graphene Oxides for Biomedical Applications

Alaithan,

Khalaf,

Gouda

et al. 2023

Chemistry & Biodiversity

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Bacterial infections that cause chronic wounds provide a challenge to healthcare worldwide because they frequently impede healing and cause a variety of problems. In this study, loaded with tungsten oxide (WO3), Magnesium oxide (MgO), and graphene oxide (GO) on chitosan (CS) membrane, an inexpensive polymer casting method was successfully prepared for wound healing applications. All fabricated composites were characterized by X‐ray powder diffraction (XRD), Fourier transforms infrared spectroscopy (FT‐IR), and thermogravimetric analysis (TGA). A scanning electron microscope (SEM) was used to study the synthesized film samples’ morphology as well as their microstructure. The formed WO3/MgO@CS shows a great enhancement in the UV/VIS analysis with a highly intense peak at 401 nm and a narrow band gap (3.69 eV) compared to pure CS. The enhanced electron‐hole pair separation rate is responsible for the WO3/MgO/GO@CS scaffold's antibacterial activity. Additionally, human lung cells were used to determine the average cell viability of nanocomposite scaffolds and reached 121 % of WO3/MgO/GO@CS nanocomposite, and the IC50 value was found to be 1654 μg/mL. The ability of the scaffold to inhibit the bacteria has been tested against both E. coli and S. aureus. The 4th sample showed an inhibition zone of 11.5±0.5 mm and 13.5±0.5 mm, respectively. These findings demonstrate the enormous potential for WO3/MgO/GO@CS membrane as wound dressings in the clinical management of bacterially infected wounds.

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Synthesis, Characterization of C-Zn/Pd-Np as Potential Nanocomposites Against Human Lung Cancer Cells (A549) and Pathogenic Microorganisms

dhorai,

Manickam,

Rangaraj

et al. 2024

J Inorg Organomet Polym

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PalladiumwrappedZnOnanocomposites synthesis through carrageenan were madeas bimetallic nanocomposites (C-Zn/Pd-Np) and their antibacterial, and anticancer e cacy were assessedunderin vitro condition.Further,they were physico-chemically characterized. The metal complex werecharacterized using a variety of physico-chemical techniques, including scanning electron microscopy (SEM), X-ray diffraction (XRD), and infrared spectroscopy (FT-IR). The bimetallic nanocomposites are more crystalline according to XRD analysis. IR spectra indicate faint multiple bands in the far infrared range because ofmetal-metal interactions and the absence of usual bands of acetate and nitrate groups. P. aeruginosa, S. aureus, B. subtilis andEscherichia coliwere used to test te antibacterial activity of the nanocomposites. The outcomes demonstrated signi cant antibacterial e cacy against all of the investigated pathogens. The antiproliferative effectiveness of the nanocomposites against A549 cancer cell types aresigni cantly enhanced with anincreased concentration.It also resulted in cell cycle arrest, apoptosis, and necrosis found in bimetallic nanocomposites treated cells. In conclusion, (C-Zn/Pd-Np) has notable antibacterial action and is effective against at inhibiting the growth of lung cancer cells. According to this present study, C-Zn/Pd-Np may be useful for the effective clinical management of Human pathogensand lung cancer cells.

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Effects of biogenic synthesis of chitosan entrapped silver nanoparticle from Aegle marmelos on human cervical cancer cells (HeLa)

Cited by 14 publications

References 40 publications

Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

Improving the Durability of Chitosan Films through Incorporation of Magnesium, Tungsten, and Graphene Oxides for Biomedical Applications

Synthesis, Characterization of C-Zn/Pd-Np as Potential Nanocomposites Against Human Lung Cancer Cells (A549) and Pathogenic Microorganisms

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