Effects of black cohosh and estrogen on the hypothalamic nuclei of ovariectomized rats at different temperatures

Zhang, Hui; Ma, Xiao; Yang, Mukun; Wang, Ke; Yang, Lei; Zhu, Shijun; Jia, Junjing; Qin, Lihua; Bai, Wenpei

doi:10.1016/j.jep.2012.05.059

Cited by 23 publications

(11 citation statements)

References 24 publications

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“…iCR ameliorates an ovariectomy-induced decrease in a serotonin dorsal raphe–preoptic hypothalamus pathway [33]. iCR recovered the activity of neurons in the preoptic area in the hypothalamus which were impaired by oestrogen deprivation [34, 35]. After iCR treatment, neurons recovered their sensitivity to temperature changes and were identified as active neurons [34].…”

Section: It’s In the Brain: Pathophysiology Of Hot Flushes/sweating Amentioning

confidence: 99%

“…iCR recovered the activity of neurons in the preoptic area in the hypothalamus which were impaired by oestrogen deprivation [34, 35]. After iCR treatment, neurons recovered their sensitivity to temperature changes and were identified as active neurons [34]. These data suggest that alleviation of VMS by CR/iCR is not caused by oestrogen-agonistic effects.…”

Section: It’s In the Brain: Pathophysiology Of Hot Flushes/sweating Amentioning

confidence: 99%

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60 years of Cimicifuga racemosa medicinal products

Zepelin

2017

Wien Med Wochenschr

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Summary Cimicifuga racemosa (CR) extracts are important worldwide as therapy for menopausal symptoms. The first medicinal product from CR has been available since 1956 (Germany, Remifemin® [Schaper & Brümmer, Salzgitter, Germany], isopropanolic extract iCR). This review describes how CR developed, via clinical studies on safety (breast, breast cancer, endometrium, liver) and efficacy, into a successful and safe medicinal product in Germany, Europe and the world. In line with developing legal frameworks for medicinal products in Germany and Europe, clinical studies on CR were observational during the 50s and 70s, and controlled studies since the 80s. The first placebo-controlled study emerged 1986. From 2000 to 2015, a total of 28 clinical studies in Europe, America and Asia were published on the efficacy of CR. In these studies, 11,073 patients received a CR-based medicinal product, 93% thereof iCR. A meta-analysis of all nine placebo-controlled studies published until 2013 confirmed the reliable efficacy of CR-based medicinal products for menopausal symptoms.

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Section: It’s In the Brain: Pathophysiology Of Hot Flushes/sweating Amentioning

confidence: 99%

Section: It’s In the Brain: Pathophysiology Of Hot Flushes/sweating Amentioning

confidence: 99%

60 years of Cimicifuga racemosa medicinal products

Zepelin

2017

Wien Med Wochenschr

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“…abnormalities in kidney function, malaria, rheumatism, general malaise, sore throat, menstrual irregularities and for the relief of menopause-related symptoms [4,7]. Clinical studies suggest that black cohosh is effective in relieving emotional symptoms, especially depression or anxiety, and hot flushes during menopause [3]. The chemical constituents of C. racemosa include two classes of secondary metabolites: triterpene glycosides and phenolics compounds [4].…”

Section: Doi: 102478/cipms-2014-0025mentioning

confidence: 99%

“…Cimicifuga racemosa (L.) Nutt. (Actaea racemosa, also known as black cohosh), is a perennial herb belonging to the buttercup family (Ranunculaceae) [3]. The roots and rhizomes of C. racemosa are traditionally used to treat a Cimicifuga racemosa, is a plant with a diverse and long history of medicinal use.…”

Section: Introductionmentioning

confidence: 99%

Determination of caffeic acid in root and rhizome of Black cohosh (Cimicifuga racemosa (L.) Nutt.)

Zapała

Szymczak

Wójciak–Kosior

2014

Current Issues in Pharmacy and Medical Sciences

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Cimicifuga racemosa, is a plant with a diverse and long history of medicinal use. Caffeic acid, bioactive compound, which often occurs with other polyphenols can influence the biological activity of this plant. The aim of our work was quantitative analysis of caffeic acid in roots and rhizomes of two varieties of C. racemosa. Analysis was performed by HPLC method. The extracts were separated on C18 reversed-phase column using mixture of methanol, water and formic acid (25:75:0.5 v/v/v) as a mobile phase. The flow rate of eluent was 1.0 ml·min-1. The obtained validation parameters such as linearity, linear regression equation and precision expressed as a relative standard deviation were adequate for quantitative determination. Caffeic acid was found in all tested extracts. The highest total amount of caffeic acid was determined in C. racemosa var. racemosa (255.3 μg·g-1) while its concentration in C. racemosa var. cordifolia was significantly lower (213.0 μg·g-1).

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“…Our previous work demonstrated that the abnormal thermoregulation in ovariectomized (OVX) rats resulted in increased central body temperature (CBT) during the day and night, a greater CBT difference between day and night, and a higher amplitude of CBT fluctuation frequency [5]. In addition, c- fos expression decreased obviously in the MnPO, VMPO, VLPO, and MPA under different temperature stimulation after OVX, indicating that OVX had altered the temperature sensitivities of the MnPO, VMPO, VLPO, and MPA [6]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Estradiol Valerate and Remifemin on Norepinephrine Signaling in the Brain of Ovariectomized Rats

et al. 2015

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Aims: We investigated the norepinephrine pathway changes from the locus coeruleus (LC) to the preoptic area of the hypothalamus (POAH) in the brain of ovariectomized rats under low estrogen levels and explored the therapeutic effects of estradiol valerate (E₂) and Remifemin (ICR) on these changes. Methods: 40 female Sprague-Dawley rats were randomly divided into the following groups: surgery with vehicle (SHAM), ovariectomy surgery with vehicle (OVX), ovariectomy with E₂ treatment (OVX + E₂), and ovariectomy with Remifemin (OVX + ICR). After 4 weeks of treatment, we observed the changes by immunohistochemistry. Results: (1) The average optical density of DBH-ir fibers and the number of α₁-adrenoreceptor- and estrogen receptor (ER)α-positive neurons in the main nuclei of POAH were all reduced in OVX rats compared with the SHAM group. The above changes were normalized in all nuclei of the POAH in the E₂ group, while they were normalized in some nuclei in the ICR group. Coexpression of ERα and α₁-adrenoreceptor was observed in the POAH. (2) The number of DBH- and ERα-positive neurons in the LC decreased in the OVX group compared with the SHAM group and increased after treatment with E₂ and ICR. Coexpression of ERα and DBH was observed in the LC. Conclusion: Low estrogen (OVX) altered norepinephrine synthesis in the LC, the projection of norepinephrine fibers and α₁-adrenoreceptor expression in the POAH. Both E₂ and ICR normalized the norepinephrine pathway, but E₂ achieved greater effects than ICR. ICR had different effects in different nuclei in the POAH and its therapeutic effect was better in the LC.

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Effects of black cohosh and estrogen on the hypothalamic nuclei of ovariectomized rats at different temperatures

Cited by 23 publications

References 24 publications

60 years of Cimicifuga racemosa medicinal products

60 years of Cimicifuga racemosa medicinal products

Determination of caffeic acid in root and rhizome of Black cohosh (Cimicifuga racemosa (L.) Nutt.)

Effects of Estradiol Valerate and Remifemin on Norepinephrine Signaling in the Brain of Ovariectomized Rats

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