Effects of Blue and White Light on Infant (Gunn) Rats and on Lactating Mother Rats

Ballowitz, L

doi:10.1159/000240434

Cited by 11 publications

(2 citation statements)

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“…The use of phototherapy alone has been employed in several studies involving ji Gunn rats (10,11,(16)(17)(18), but renal functional parameters were never determined. Phototherapy has also been used extensively in many neonatal intensive care units to lower the concentration of unconjugated serum bilirubin in newborn and especially premature infants (19), thereby minimizing the chances for the development of kernicterus with attendant brain damage.…”

Section: Resultsmentioning

confidence: 99%

The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin.

Call¹,

Tisher²

1975

J. Clin. Invest.

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A B S T R A C T The role of high serum and tissue levels of unconjugated bilirubin in the pathogenesis of the impaired urinary concentrating ability was investigated in homozygous (fi) Gunn rats with the congenital absence of hepatic glucuronyl transferase. Continuous phototherapy with blue fluorescent lights at a wave length of 460 nm or oral cholestyramine feeding or both reduced serum levels of unconjugated bilirubin to levels consistently below 3.0 mg/100 ml for several weeks in both weanling and adult fi Gunn rats. The renal concentrating defect was already present in weanling jj Gunn rats by 21 days of age. In treated weanling jj animals, maximum concentrating ability and the concentration of urea and nonurea solutes in the papilla and medulla, determined after 24 h of fluid deprivation, were normal when compared to unaffected heterozygous (Jj) littermates. Solute-free water reabsorption which is reduced in jaundiced fi Gunn rats was restored to normal in treated weanling ji rats. The tissue concentration of unconjugated bilirubin was reduced throughout the papilla and inner and outer medulla in the treated jj rats in comparison with untreated jj littermates. The defect in urinary concentrating ability was only partially reversible and sometimes irreversible in adult ji rats, probably because of permanent renal parenchymal damage occurring secondary to massive crystalline deposits in the papilla and medulla.

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Section: Resultsmentioning

confidence: 99%

The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin.

Call¹,

Tisher²

1975

J. Clin. Invest.

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“…The observed differences in the growth of these two organs may be related to the severity of malnutrition suffered by the photoirradiated rabbits, since malnutrition tends to spare the brain more than other organs [11]. In addi tion, the brain in rabbits is much more mature at birth than the brain in rats at birth so that growth retarding effect may not be demonstrable with mar ginal malnutrition.…”

Section: Discussionmentioning

confidence: 96%

Changes in Cellular Growth in Newborn Rats and Rabbits Exposed to Photoirradiation

Wu¹,

Yoshida²

1975

Neonatology

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Effects of photoirradiation from lamps currently used in phototherapy on growth in newborn rats and rabbits were studied. The newborn animals subjected to 96 h of phototherapy were found to be smaller than comparable nonirradiated animals. Mean organ weight of the brain, liver, heart and kidney was lower in the photoirradiated groups than in the nonirradiated group. DNA, protein content, protein/DNA ratio, cell number and cell size were also significantly reduced (p = < 0.01) in the photoirradiated groups when compared to the nonirradiated group. The degree of growth retardation was more pronounced in rats subjected to continuous photoirradiation than intermittent photoirradiation (12 h on and 12 h off).

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The damaging effects of light on the retina. Empirical findings, theoretical and practical implications

Lanum

1978

Survey of Ophthalmology

240

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Effects of Blue and White Light on Infant (Gunn) Rats and on Lactating Mother Rats

Cited by 11 publications

References 1 publication

The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin.

The urinary concentrating defect in the Gunn strain of rat. Role of bilirubin.

Changes in Cellular Growth in Newborn Rats and Rabbits Exposed to Photoirradiation

The damaging effects of light on the retina. Empirical findings, theoretical and practical implications

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