Effects of Bonito Elastin HC on Skin Dryness, Wrinkles, and Pigmentation In Vitro and In Vivo

Oral consumption of Bonito fish‐derived elastin peptide (VGPG Elastin®) improves biophysical properties in aging skin: A randomized, double‐blinded, placebo‐controlled study

“…Further, the improvement in skin hydration, which contributes to plump, smooth, and moisturized skin, can be explained by increased water content and upregulated expression of hyaluronic acid and hydroxyproline following oral elastin peptide intake in mice, which is similar to the effect of collagen 15,23 . Oral consumption of elastin peptide was found to modify the mRNA expression of long‐chain base 1, dihydroceramide desaturase 1, elastin, the protein expression of hyaluronan synthase 2, and ceramide synthase 4, which affects skin moisturization in UV‐irradiated HaCaT keratinocytes and hairless mice 13 . Therefore, elastin peptide intake strengthens the skin barrier and enhances hydration, which was consistent with the findings of the present study.…”

“…25 These results were similar to those of an in vivo experiment on hairless mice. 13 Thus, considering the cross-talk in photoaging among keratinocytes, melanocytes, and fibroblasts, oral administration of elastin peptide can be a promising option for anti-wrinkle, anti-dryness, and anti-pigmentation treatment. While the erythema index decreased in both groups with no significant differences between them, we attribute this observation to the impact of weather, meaning that skin erythema worsened during the winter due to the dry and cold conditions.…”

“…Moreover, senescent cells release various pro‐inflammatory cytokines, such as IL‐1α, IL‐1β, IL‐6, tumor necrosis factor‐α, and MMPs, which are involved in the regulation of collagen and elastin synthesis 7 . Interestingly, Bonito fish‐derived elastin peptide stimulated the expression of TGF‐β, procollagen type I, and collagen type I while downregulating the protein expression of p‐Smad3/Smad (negative factors of the TGF‐ β/Smad pathway), MAPK signaling pathways involving JNK, Fos, Jun, and MMP‐1, 3, and 9 as well as the above‐mentioned pro‐inflammatory cytokines in UVB‐irradiated human fibroblasts and hairless mice 13 . These findings align with our clinical data on the positive effect of elastin peptide consumption in improving skin wrinkles and roughness.…”

“…[13][14][15][16][17] These peptides enhance elastin synthesis and fibroblast proliferation, reduce epidermal thickness in photodamaged skin, and attenuate UV-induced cellular damage. 13,14,16,17 Similar to collagen peptides that have become a popular treatment modality for skin rejuvenation, 18 elastin peptide shows promise as a therapeutic agent. However, only a few clinical trials have evaluated the efficacy of oral elastin peptide supplementation.…”

“…have reported that prolyl‐glycine (Pro‐Gly), a major food‐derived elastin peptide, reaches peak serum concentration within 30 min of elastin hydrolysate ingestion and remains detectable even after 4 h in human peripheral blood 12 . Further, recent in vitro and in vivo data have supported the efficacy of elastin peptides in improving skin health 13–17 . These peptides enhance elastin synthesis and fibroblast proliferation, reduce epidermal thickness in photodamaged skin, and attenuate UV‐induced cellular damage 13,14,16,17 …”