Effects of bradykinin on proliferation, apoptosis, and cycle of glomerular mesangial cells via the TGF-β1/Smad signaling pathway

Ji, Dong; Ding, Li; Wang, Liuwei; Yang, Zhipeng; Wang, Yulin; Zang, Ying; Cao, Xuexia; Tang, Lin

doi:10.3906/biy-2007-58

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…These results indicated that CAV-1 was involved in redoxosomes signaling and may be a novel therapeutic target of DKD. The TGF-β1/SMAD signaling has an important role in renal fibrosis, the activation of which is crucial to the formation of the ECM ( 32 , 33 ). The present results indicated that CAV-1 could also activate TGF-β1/SMAD signaling, which may result in ECM accumulation in MCs under hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Procyanidin B2 suppresses hyperglycemia‑induced renal mesangial cell dysfunction by modulating CAV‑1‑dependent signaling

Yin

Wang²,

Zhu³

et al. 2022

Exp Ther Med

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The dysfunction of renal mesangial cells (MCs) is a hallmark of diabetic kidney disease (DKD), which triggers glomerulosclerosis leading to end-stage renal disease. Procyanidin B2 (PB2), the main component of proanthocyanidin, is well known for its antioxidant and anti-inflammatory effects; however, it remains unclear as to whether it has protective effects on DKD. The present study investigated the protective effect of PB2 against hyperglycemia-induced renal MC dysfunction in mouse SV40-Mes13 (Mes13) cells. The Mes13 cells were treated with or without PB2 under HG conditions. Cell proliferation was assessed using an MTT assay and oxidative stress was assessed by examining intracellular ROS generation and H 2 O 2 production. The changes in extracellular matrix accumulation- and cellular inflammation-related proteins were measured by western blot analysis, ELISA and immunofluorescence analysis. The results showed that PB2 treatment markedly attenuated hyperglycemia-induced cell proliferation, oxidative stress, extracellular matrix accumulation and cellular inflammation in Mes13 cells, which was accompanied by an inactivation of redoxosomes, TGF-β1/SMAD and IL-1β/TNF-α/NF-κB signaling pathways. The present study also demonstrated that hyperglycemia upregulated and activated caveolin-1 (CAV-1), whereas PB2 treatment potently reversed this effect. In accordance, CAV-1 overexpression abolished the protective effects of PB2 against hyperglycemia in Mes13 cells, indicating that the cytoprotective effect of PB2 was CAV-1-dependent. These findings form the basis of the potential clinical applications of PB2 in the treatment of DKD.

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Section: Discussionmentioning

confidence: 99%

Procyanidin B2 suppresses hyperglycemia‑induced renal mesangial cell dysfunction by modulating CAV‑1‑dependent signaling

Yin

Wang²,

Zhu³

et al. 2022

Exp Ther Med

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Experimental Study on the Dynamic Mechanical Properties of a Jointed Rock Mass under Impact Loading

Feng

Wang

et al. 2022

Shock and Vibration

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The propagation law of blast stress waves in jointed rock masses is closely related to the characteristics of the joint filling medium. The water content and thickness of the filling medium affect the propagation characteristics of the blast stress wave in the joint surface. Based on similarity theory, mortar-red clay-mortar composite specimens with different moisture contents (36%, 39%, 42%, and 45%) and medium thicknesses (3 mm, 6 mm, and 9 mm) were prepared with red clay as the filling medium. The dynamic uniaxial compression test of the specimen under different strain rates was carried out by using a variable cross-section split Hopkinson compression bar with a diameter of 50 mm. The effects of strain rate, moisture content, and medium thickness on the stress wave propagation characteristics, dynamic stress-strain curve, peak stress, crushing energy consumption density, and crushing characteristics of mortar-red clay-mortar composite specimens were analyzed. The results show that the blocking effect of joints on stress waves increases significantly with increasing filling medium thickness and water content. With increasing strain rate, the peak stress and energy of the composite specimen increase and there is an obvious strain rate effect. With the increase in the thickness and moisture content of the filling medium, the peak stress, dynamic elastic modulus, energy consumption density per unit volume, and crushing degree of the specimen gradually decrease and the nonlinear deformation is more obvious. There is a good linear relationship between the peak stress and the thickness and moisture content of the filling medium. The existence of joints greatly weakens the damage effect of stress waves on the specimens behind the joints, and with the increase in the thickness and water content of the filling medium, the degree of damage to the specimens behind the joint surface decreases under the same impact pressure and the weakening effect becomes increasingly significant.

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Autoregulation: mediators and renin–angiotensin system in diseases and treatments

Mansour

2023

Futur J Pharm Sci

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Background Hemodynamic regulation is a substantial part of the physiological integrity of the human body. It is based on the delivery of proper blood perfusion to every organ. Five primary vasoactive substances are nearly located throughout the human body, either released from the endothelium, prostanoids, nitric oxide (NO), and endothelin-1 (ET-1); or considered as hormones, bradykinin (BK) and natriuretic peptides (NPs). Main body The circulating mediators are in synchronization with the renin–angiotensin system (RAS) during the pathogenesis of the main vital organs, heart, kidney, lung, liver, and brain. The RAS system has been an extensive therapeutic approach for cardiovascular and renal diseases for decades, but more recently became a crucial regulator of hemodynamics in other organs after the actions of its components were detected in other organs. All the mentioned disorders here begin with the initiation of abnormal imbalance between vasoactive mediators which causes vascular dysfunction and histopathological situations that may induce oxidative stress which exaggerates the disorder if there is no clinical intervention. Conclusion We will review the currently identified signaling pathways and the possible relationships between those compounds elucidating how they interfere with serious diseases including cardiovascular diseases (CVDs), chronic kidney disease (CKD), pulmonary arterial hypertension (PAH), portal hypertension (PHT), and Alzheimer's disease (AD). Thus, this updated review summarizes years of work that aims to define the contribution of each mediator in both normal and pathological states, besides the drugs based on their activity and their places in either preclinical or clinical trials.

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Effects of bradykinin on proliferation, apoptosis, and cycle of glomerular mesangial cells via the TGF-β1/Smad signaling pathway

Cited by 3 publications

References 26 publications

Procyanidin B2 suppresses hyperglycemia‑induced renal mesangial cell dysfunction by modulating CAV‑1‑dependent signaling

Procyanidin B2 suppresses hyperglycemia‑induced renal mesangial cell dysfunction by modulating CAV‑1‑dependent signaling

Experimental Study on the Dynamic Mechanical Properties of a Jointed Rock Mass under Impact Loading

Autoregulation: mediators and renin–angiotensin system in diseases and treatments

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