Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

Moon, Chang-Kiu; Chung, Jin; Lee, You‐Mie; Lee, Soo‐Hwan; Hwang, Gwi-Seo; Park, Kwangsik; Mock, Myung-Soo; Kim, Seong‐Gon; Ahn, Yo Han; Ann, Jeong-Hee

doi:10.1007/bf02857719

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…Caesalpin P, sappanchalcone, 3-deoxysappanone, brazilin, and protosappanin A have been isolated and identified as aldose reductase inhibitors to be useful for the treatment of diabetic complications, of which, sappanchalcone at a dose of 10 5 mol/l can inhibit 84% of aldose reductas (Moon, 1986;Moon et al, 1988;Morota et al, 1990). Some preparations have been put into clinical use (Moon, 1986;Morota et al, 1990).…”

Section: Caesalpinia Sappan L (Leguminosae)mentioning

confidence: 97%

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Zheng

Bukuru

et al. 2004

Journal of Ethnopharmacology

805

524

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Section: Caesalpinia Sappan L (Leguminosae)mentioning

confidence: 97%

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Zheng

Bukuru

et al. 2004

Journal of Ethnopharmacology

805

524

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“…China, ). Pharmacological investigation had demonstrated that Sappan Lignum showed various biological activities such as anti‐tumor (Wang et al ., ; Peng and Gu, ), immunosuppressive (Choi et al ., ; Ye et al ., ), antibiosis and antiphlogosis (Niranjan Reddy et al ., ; Wu et al ., ), antioxidant (Badami et al ., ; Hu et al ., ), hypoglycemic activities (Moon et al ., ; Zhang et al ., ), and so on.…”

Section: Introductionmentioning

confidence: 97%

A validated LC‐MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

Deng

Wang

Zhao

et al. 2013

Biomedical Chromatography

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Brazilin is a major homoisoflavonoid component isolated from the dried heartwood of traditional Chinese medicine Caesalpinia sappan L., which is a natural red pigment used for histological staining. Herein a sensitive, specific and rapid analytical LC-MS/MS method was established and validated for brazilin in rat plasma. After a simple step of protein precipitation using acetonitrile, plasma samples were analyzed using an LC-MS/MS system. Brazilin and the IS (protosappanin B) were separated on a Diamonsil C18 analytical column (150 × 4.6 mm, 5 µm) using a mixture of water and 10 mm ammonium acetate in methanol (20:80, v/v) as mobile phase at a flow rate of 0.6 mL/min. The method was sensitive with a lower limit of quantitation of 10.0 ng/mL, with good linearity (r(2) ≥ 0.99) over the linear range 10.0-5000 ng/mL. All the validation data, such as accuracy and precision, matrix effect, extraction recovery and stability tests were within the required limits. The assay method was successfully applied to evaluate the pharmacokinetics parameters of brazilin after an oral dose of 100 mg/kg brazilin in rats.

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Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

et al. 1990

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Effects of brazilin on erythrocyte deformability and its related biochemical factors in streptozotocin induced diabetic rats

Cited by 6 publications

References 14 publications

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus

A validated LC‐MS/MS method for rapid determination of brazilin in rat plasma and its application to a pharmacokinetic study

Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

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