Effects of budesonide and fluticasone propionate in a placebo‐controlled study on symptoms and quality of life in seasonal allergic rhinitis

Ciprandi, Giorgio; Canonica, Giorgio Walter; Grosclaude, M.; Ostinelli, J.; Brazzola, Giancarlo; Bousquet, Jean

doi:10.1034/j.1398-9995.2002.03228.x

Cited by 60 publications

(52 citation statements)

References 11 publications

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“…The improvement of health-related quality of life is an important goal in the management of patients with allergic rhinitis [27,28,29,30]. In the present study, as well as in the previous guideline validation study, we used the well-validated disease-specific RQLQ and confirmed that the improvement in RQLQ scores in the patients treated according to the guidelines strategy was significantly greater than that observed in patients treated according to the free-choice treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

Implementation of Guidelines for Allergic Rhinitis in Specialist Practices

Bousquet

Bodez

Gehano

et al. 2009

Int Arch Allergy Immunol

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Background: Guidelines for allergic rhinitis are more effective than free-treatment choice in the control of seasonal allergic rhinitis. Objective: To validate the ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines in the treatment of intermittent and persistent allergic rhinitis induced by pollens. Design: A multicenter, open-label, parallel, pragmatic randomized study compared two therapeutic strategies during a 2-week treatment course. In the first strategy (‘guidelines group’), 417 patients were treated according to ARIA with ebastine as oral antihistamine. In the second strategy (‘free-choice treatment group’), investigators had a free choice for the treatment of 422 patients. Main Outcome Measures: Quality of life measured using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), work productivity and daily symptom medication scores. Results: 94.2% patients returned the baseline visit questionnaires and 88.6% returned the posttreatment period questionnaires. RQLQ scores were similar in the two groups at baseline. After treatment, there were improvements in the overall score and in all domains in both treatment groups. According to pragmatic methodology, the improvements show that the guidelines group (–1.70 ± 1.20) is more effective than the free-choice treatment group (–1.52 ± 1.22) with a γ risk of 2%. Individual RQLQ scores, work productivity, and daily symptom scores were significantly improved in the guidelines group by comparison to the free-choice treatment group. Conclusion: A treatment based on ARIA guidelines offers patients a significant improvement in comparison to the use of a nonstandardized treatment regimen.

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Section: Discussionmentioning

confidence: 99%

Implementation of Guidelines for Allergic Rhinitis in Specialist Practices

Bousquet

Bodez

Gehano

et al. 2009

Int Arch Allergy Immunol

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“…Generic questionnaires of QOL show an improvement of QOL in patients treated with oral H 1 -antihistamines and intranasal glucocorticosteroids in seasonal (1065,1075,1076), perennial (1077,1078) and PER (1067). However, the improvement is usually less important than with specific questionnaires (1065, 1067).…”

Section: Social Lifementioning

confidence: 99%

“…The SF-36 has been used to characterize patients with perennial rhinitis (52, 88), seasonal (1063)(1064)(1065) and PER (1066)(1067)(1068). A new instrument examining satisfaction in 32 aspects of daily life [the Satisfaction Profile (SAT-P)] was used in seasonal allergic rhinitis and was found to correlate with the SF-36 data (1069).…”

Section: Social Lifementioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

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3,861

1,761

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“…Ademais, ensaios clínicos que venham avaliar a eficácia de drogas com ação sistêmica, como é o caso dos antileucotrienos, propiciarão informa-ções úteis sobre sua eficácia comparativa com esteróides tópicos associados ou não a anti-histamínicos. É oportuno constatar que a imunoterapia específica possa, pelo menos nos casos de rinite alérgica, auxiliar na redução da hiperresponsividade brônquica inespecífica, ou até mesmo abortar o aparecimento de asma no decorrer da vida [29][30][31][32] .…”

Section: Comentários Finaisunclassified

Asma e rinite alérgica como expressão de uma única doença: um paradigma em construção

Camargos¹,

Rodrigues²,

Solé³

et al. 2002

J. Pediatr. (Rio J.)

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Objective: to describe current ideas about the relation between upper and lower respiratory tract and to review the epidemiological, immunological, and pathological aspects that support the paradigm of united airways disease.Sources: literature review using the Medline, MD Consult, HighWire, Medscape and Lilacs databases. We used allergic rhinitis and asthma as keywords, and searched articles published in the past 20 years.Summary of the findings: epidemiological evidence includes prevalence of allergic rhinitis in asthmatic patients and vice-versa, results of cross-sectional studies, bronchial hyperresponsiveness in patients with allergic rhinitis, importance of genetic and environmental factors, and the age of onset of atopic disease. Morphological and physiological aspects show structural differences between the nasal and bronchial mucosa, and the mechanisms that could explain the effect of rhinitis on asthma. Immunological aspects including the participation of bone marrow in the production of inflammatory cells and allergic reactions after allergen challenge are the same in allergic rhinitis and asthma. Finally, the results of the therapy for allergic rhinitis in bronchial hyperresponsiveness and in clinical and functional control of asthma are also reported.Conclusions: epidemiological evidence and immunological and pathological aspects suggest that there is a relation between allergic rhinitis and asthma. The paradigm of united airways disease suggests the implementation of an integrated therapeutic approach.

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Effects of budesonide and fluticasone propionate in a placebo‐controlled study on symptoms and quality of life in seasonal allergic rhinitis

Abstract: There was no significant difference in efficacy between budesonide and fluticasone in this study. However, greater improvements in quality of life were seen with budesonide than with fluticasone.

Cited by 60 publications

References 11 publications

Implementation of Guidelines for Allergic Rhinitis in Specialist Practices

Implementation of Guidelines for Allergic Rhinitis in Specialist Practices

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Asma e rinite alérgica como expressão de uma única doença: um paradigma em construção

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