Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy subjects

Abstract

SUMMARYBackground: The most frequently reported adverse events associated with acetylsalicylic acid intake are minor gastrointestinal complaints. Galenic modifications, such as buffered formulations with or without ascorbic acid, may improve the benefit-risk ratio by decreasing the local mucosal side-effects of acetylsalicylic acid. Aim: To assess endoscopically-proven gastrointestinal lesions and the amount of gastric microbleeding of four different buffered and plain acetylsalicylic acid formulations, one containing paracetamol. Methods: A randomized, four-fold cross-over study was performed in 17 healthy subjects who underwent serial oesophago-gastro-duodenoscopy before and after each course of 4-day dosing. Gastric aspirates were collected

Determinação simultânea de ácido ascórbico e ácido acetilsalicílico usando análise por injeção em fluxo com detecção amperométrica pulsada

“…A Figura 4 apresenta os amperogramas obtidos nos pulsos de potenciais de +0,90 e +1,35 V em função da injeção, em triplicata, de soluções padrão contendo, respectivamente, AA e AS: os resultados médios (n = 3) de ambos os métodos não apresentaram diferença significativa em um nível de confiança de 95%, sendo que o t calculado foi inferior ao t tabelado (2,78). Somente a amostra 1 apresentou um valor calculado superior ao valor tabelado.…”

“…Segundo estudos realizados, quando o AAS está associado com AA, são necessárias doses menores de AAS para se atingir o mesmo benefício, com consequente diminuição na indução de efeitos colaterais provocados pelo AAS. 2 Além disto, as características antioxidantes do AA também estão presentes. 3 A presença dos dois princípios ativos (AA + AAS) na mesma formulação é vantajosa.…”

The use of acetylsalicylic acid in patients with IHD

“…Свой защитный эффект невсасывающиеся антациды реализуют через адсорбцию соляной кислоты и образование с ней буфер-ного соединения. Кроме того, снижается активность пеп-сина, происходит связывание лизолецитина и желчных кислот, оказывающих неблагоприятное влияние на сли-зистую желудка [46]. Гидроксид магния, входящий в состав Кардиомагнила, является более быстродействующим антацидом по срав-нению с гидроксидом алюминия, что чрезвычайно важ-но при использовании особых форм АСК.…”

Gastrointestinal Effects of the Addition of Ascorbic Acid to Aspirin

“…The aspirin plus paracetamol plus caffeine group was associated with the highest mean Lanza score (2.5 ± 1.2), followed by plain aspirin (mean 2.3 ± 1.3) and buffered aspirin (mean 2.0 ± 1.5). Additionally, pairwise comparisons revealed that aspirin plus ascorbic acid had significantly lower Lanza scores compared to the other treatments ( P < 0.005) 13 …”

“…Medication was administered 3 times a day, and each treatment period lasted 4 days. Gastrointestinal damage was evaluated by endoscopy the morning before the first intake of medication and on day 4 following the last dose 13 …”