Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity

Jamall, Ijaz S.; Smith, J. C.

doi:10.1016/0041-008x(85)90098-5

Cited by 226 publications

(105 citation statements)

References 24 publications

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“…Long-term exposure to Cd increases lipid peroxidation and causes inhibition of SOD activity, resulting in oxidative damage to liver, kidney and testes [11]. Also in the Cdtreated group, hepatic LPO increased and SOD and CAT activities were decreased, as observed in earlier studies [29,30]. The increased LPO may be due to decreased activities of SOD and CAT, the free radical scavenging enzymes [31].…”

Section: Discussionmentioning

confidence: 48%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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Cadmium is one of the elements found to damage antioxidant systems in mammals. To ameliorate cadmium toxicity and to prevent oxidative stress, natural products may be useful. In Indian ethnobotanical practice, a mixture of 17 herbal products is used to fortify the reproductive system of women after parturition and to reverse ovarian oxidative stress. Oral administration of this extract to rats exposed to cadmium was useful in reversing oxidative stress. Two different doses of cadmium (50 ppm and 200 ppm) were given to Wistar rats aged 45 and 65 days. An herbal extract derived from 17 plants was administered orally every day at a dose level of 200 mg/kg of body weight to the rats exposed to cadmium. A battery of enzymes involved in antioxidant activity in the ovary, including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-s-transferase (GST) were measured in the control, cadmium-exposed rats without treatment and in the cadmium-exposed rats treated with herbal extract. The reduction in SOD, catalase, GPx and GST activity after cadmium exposure improved significantly in the rats treated with the herbal extract (p<0.05). The decrease of antioxidant enzymes due to cadmium exposure was reversed significantly with herbal extract administration. The synergistic effect of each bioactive compound in different herbal extracts requires further study.

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Section: Discussionmentioning

confidence: 48%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

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“…MPO activity in colon tissue was estimated by the method described previously (Krawisz et al 1984). One unit of MPO activity is defined as that degrading 1 lmol of peroxide per minute at 25 C. LPO was assessed by a previously reported method (Jamal & Smith 1985) with some modifications and is expressed as nM MDA/g tissue. The activities of superoxide dismutase (SOD) (Marklund & Marklund 1974) and catalase (CAT) (Aebi 1984) were assessed as described previously and are expressed as units/g of tissue.…”

Section: Estimation Of Biochemical Parametersmentioning

confidence: 99%

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Dey

Sharma

Wanjari

et al. 2016

Pharmaceutical Biology

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Context: The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment of different gastrointestinal and inflammatory disorders. Objective: The present study evaluated the effects of extracts of Amorphophallus paeoniifolius tubers on acetic acid-induced ulcerative colitis (UC) in rats. Materials and methods: Wistar rats were orally administered methanol extract (APME) or aqueous extract (APAE) (250 and 500 mg/kg) or standard drug, prednisolone (PRDS) (4 mg/kg) for 7 days. On 6th day of treatment, UC was induced by transrectal instillation of 4% acetic acid (AA) and after 48 h colitis was assessed by measuring colitis parameters, biochemical estimations and histology of colon. Results: APME or APAE pretreatment significantly (p < .05-.001) prevented AA-induced reduction in body weight and increase in colitis parameters viz. stool consistency, colon weight/length ratio and ulcer score, area and index. Extracts treatment attenuated (p < .001) increase in alkaline phosphatase and lactate dehydrogenase in serum and myeloperoxidase activity and cytokines in colon tissue due to AA administration. Extracts treatment prevented AA-induced elevation in lipid peroxidation and decline in activities of superoxide dismutase and catalase and reduced-glutathione content (p < .05-.001) along with histopathological alterations. PRDS also showed similar ameliorative effect on colitis. Discussion and conclusion: APME and APAE showed a preventive effect on UC, and ameliorated inflammation and oxidative damage in colon. The effects may be attributed to presence of phytochemicals, betulinic acid, b-sitosterol, and glucomannan. In conclusion, the tuber of Amorphophallus paeoniifolius exhibited an anticolitic effect through anti-inflammatory and antioxidant action. ARTICLE HISTORY

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“…Also, the method of Ohkawa et al (1979) modified by Jamall and Smith (1985) was used for the determination of MDA in pancreas tissue samples. Moreover, the plasma MDA level was determined according to the method by Kurtel et al (1992).…”

Section: Determination Of Antilipid Peroxidation Property Of the Extractmentioning

confidence: 99%

Antidiabetic, antioxidant, and antilipid peroxidative activities ofDracocephalum polychaetumshoot extract in streptozotocin-induced diabetic rats:In vivoandin vitrostudies

Pouraboli

Nazari

Sabet

et al. 2015

Pharmaceutical Biology

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Context: Dracocephalum polychaetum Bornm. (Lamiaceae) is used in folk medicine and contains antioxidant agents. Objectives: The objective of this study is to investigate the antidiabetic, antioxidant, and antilipid peroxidative properties of methanol extract of D. polychaetum aerial parts. Materials and methods: The effect of extract (200, 300, and 400 mg/kg, b.w.) on oral glucose tolerance test (OGTT) was investigated. Also, extract (300 mg/kg) administered orally in diabetic rats for 14 d then, serum levels of some biochemical factors were evaluated. Pancreas samples were used for the determination of malondealdehyde (MDA) level, glutathione (GSH) content, superoxide dismutase, and catalase enzyme activities. Red blood cells (RBCs) and plasma were used for MDA estimation. Pancreatic a-amylase inhibition, DPPH (1,1-diphenyl-2-picrylhydrazyl), and FRAP (ferric reducing antioxidant power) assays were done. The total flavonoid content of the extract was determined by spectrophotometry. Results: Extract (300 mg/kg) decreased serum glucose level (27.1%) significantly at 120 min in OGTT. Serum levels of creatinine, triglycerides, cholesterol, alanine amino transferase and MDA levels in plasma, RBCs, and pancreas significantly decreased in treated (300 mg/kg) diabetic rats, while pancreatic GSH content, superoxide dismutase, and catalase enzymatic activities increased (p50.05). The IC 50 values for the extract and butyl hydroxyanisole were 5.6 and 1.15 mg/mL in DPPH and 0.155 and 0.062 mg/mL in the FRAP methods, respectively. The extract had no inhibitory effect on a-amylase activity. The total amount of flavonoids of the extract was estimated to be 1.8% (g/g) on the basis of quercetin content. Conclusion: Dracocephalum polychaetum shoot extract has antioxidant, antihyperlipidemic, and antilipid peroxidative properties.

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Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity

Cited by 226 publications

References 24 publications

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats

Antidiabetic, antioxidant, and antilipid peroxidative activities ofDracocephalum polychaetumshoot extract in streptozotocin-induced diabetic rats:In vivoandin vitrostudies

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