Effects of cadmium on osteoblasts and osteoclasts in vitro

Chen, Xiao; Zhu, Guoying; Gu, Shaohua; Jin, Taiyi; Shao, Chunlin

doi:10.1016/j.etap.2009.04.010

Cited by 90 publications

(50 citation statements)

References 28 publications

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“…At present, some epidemiological studies in Europe suggested low level of Cd exposure which can not cause kidney damage could decrease height, BMD and increase the risk of bone fracture [6,7]. A few studies in vitro also suggested that cadmium could alter metabolism and activity of osteoblasts [19,20] and osteoclasts [20,28]. In other words, Cd may have the direct influence on bone.…”

Section: Discussionmentioning

confidence: 99%

“…It seems that cadmium could inhibit bone formation and stimulating bone reabsorption via influencing on activity and metabolism of osteoblast and osteoclast [7,20,28]. Tracp 5b is one kind of new bone metabolic biomarkers which can be specifically secreted by osteoclast.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, calcium uptake and reabsorption in gastrointestinal gut would decrease and lead to bone mineralization. However, recent epidemiological and vitro studies suggested that Cd may have direct effect on bone [6,7,19,20], including increased risk of fracture and disturbed metabolism of osteoblast and osteoclast.…”

Section: Introductionmentioning

confidence: 99%

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Cadmium exposure induced itai-itai-like syndrome in male rats

et al. 2011

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AbstractFourteen Sprague-Dawley male rats were randomly divided into 2 groups which were given CdCl2 at the doses of 0 and 1.5 mg /kg for 12 weeks. Before sacrifice, microCT scanning were performed on the proximal tibia and urine were collected for cadmium and N-acetyl-beta-D-glucosaminidase assay, then all of rats were sacrificed and blood was collected for biomarkers measurement; bone tissues were collected for bone mass, histology and biomechanical analysis. The cadmium in blood, urine, bone and kidney of rats treated with cadmium was significantly higher than those in the control group. The bone mineral density, and bone mineral ability of rats treated with cadmium were obviously decreased by 20%–50% compared to controls. Bone microstructure index and trabecular separation of rats treated with cadmium were obviously lower (−50%) and significantly higher (+150%) than that in the control group. Bone biomechanical property decreased by 30%–60% in cadmium treated rats compared to control. Tartrate-resistant acid phosphatase 5b and alkaline phosphatase levels of rats treated with cadmium were significantly higher than those in control, but serum osteocalcin level decreased greatly by cadmium. Obvious proximal tubule damage occurred after cadmium exposure. These observations gave clear and comprehensive evidence that cadmium exposure could induce itai-itai-like syndrome in male rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cadmium exposure induced itai-itai-like syndrome in male rats

et al. 2011

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“…According to Brzóska (2012), bone fracture is the most serious consequence of the damaging action of Cd on the skeleton. This heavy metal stimulates the differentiation and activity of osteoclasts and inhibits differentiation and activity of osteoblasts (Coonse et al 2007;Chen et al 2009). These effects cause an uncoupling of the normal balance between bone formation and bone resorption resulting in decreased bone mass and increased fracture incidence (Bhattacharyya 2009), typical manifestation characteristics of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

et al. 2014

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Cadmium (Cd) and diazinon (DZN) are known to be environmental risk factors for various bone diseases including osteoporosis. Selenium (Se), an essential constituent of many antioxidant enzymes, has in higher concentrations negative effects on the bone. The present study was aimed to investigate possible changes in femoral bone of adult male rats after their acute and subchronic exposures to Cd, DZN and Se. A total of 30 male Wistar rats were randomized into three experimental groups. The rats in the group A (4-months-old) were injected intraperitoneally with a mixture of 2 mg CdCl2 kg −1 , 20 mg DZN kg −1 and 2 mg Na2SeO3 kg −1 body weight and killed 36 h after xenobiotics had been injected. In the group B, young males (1-month-old) were administered with a combination of 30 mg CdCl2 L −1 , 40 mg DZN L −1 and 5 mg Na2SeO3 L −1 in their drinking water, for 90 days. Ten 4-months-old males without toxicant supplementation served as a control group (C). After treatment period, detailed histological analysis of femoral bone was performed in each group. Our results revealed apparent osteoporotic symptoms (resorption lacunae, osteoporotic fractures) in rats from groups A and B. Moreover, histomorphometrical evaluation showed reduced bone vascularization (constricted primary osteons' vascular canals and Haversian canals) and weakness mechanical properties of bones (smaller size of the secondary osteons) in these rats in comparison with those of the control group. Our study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.

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“…Some of these substances have greater toxicity, are carried by slurry and deposited on soil and water resources. Humans exposed to them can have biochemical (enzyme changes, changes of biomolecules and transport of essential substances) and physiological changes, such as cancers and fetal abnormalities (Nollet, 2007;Chen et al, 2009;Jang et al, 2008;Lucilene et al, 2006). This heavy metal contamination arising from "dumping ground" is reported by several authors; Olowoyo et al (2012) observed the contamination of vegetable by Fe>Mn>Zn in South Africa; Opaluwa et al (2012) indicated the contamination of soil and plants (As, Cd, Co and Cu) in Nigeria; Liu et al (2013) showed the contamination of areas near garbage dumps by Cd> Cu> Cr> Zn>Pb in China.…”

Section: Introductionmentioning

confidence: 99%