Effects of caffeic acid phenethyl ester on cerebral cortex: structural changes resulting from middle cerebral artery ischemia reperfusion

Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

“…CAPE also reduced the expression of ED1 (marker of activated macrophage/microglia). Cengiz et al showed that CAPE pretreatment reduces neuroglial activation and structural changes in the cerebral cortex after middle artery cerebral ischemia/reperfusion (I/R) in rats. Serarslan et al indicated that CAPE significantly attenuated serum S‐100B level, an index for brain damage, after middle cerebral artery occlusion in rabbits.…”

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

“…It is found in all plants because it is a key intermediate in the biosynthesis of lignin, one of the principal sources of biomass [113]. The caffeic acid phenethyl ester has been found to be a potent free radical scavenger [114] and studied for its antioxidant capacities in several experimental rat models on renal impairment [115–117], retinal oxidative stress [118], myocardial oxidative stress [119], age-related vascular remodeling and cardiac damage [120], and at the same time helping to prevent the metabolic consequences in diabetes mellitus [121, 122], erythrocyte membrane ischemia/reperfusion injury [123], cerebral damage induced by ischemia reperfusion [124], and oxidative stress [125]. The mechanisms by which caffeic acid phenethyl ester exerts its anti-inflammatory action seems to depend on its effect on lipid peroxidation (LPO) and the inhibition of antioxidant enzymes such as superoxide dismutase and catalase [126].…”

Can propolis be protective against ethanol-impaired anxiety and unconditional fear?

“…NMDA (10) cancer. Recent studies show that propolis has neuroprotective effect on neuronal death [1,19,20]. However, when baselines of third and fourth group were compared it can be seen that baseline of third group was shorter than that of forth group but, the difference was insignificant.…”

“…Researcher reported that caffeic acid and terpenoids act through multiple mechanism involving free radical scavenging, metalic ion chelation and inhibitory actions on specific enzymes that induce free radical and lipid hydroperoxide formation, anti-inflammatory activity, inhibition of excitotoxicity, inhibition of cell progression [1,19,21].…”