Effects of Caffeine and Caffeinated Beverages in Children, Adolescents and Young Adults: Short Review

Soós, Rita; Gyebrovszki, Adam; Tóth, Arnold; Jeges, Sára; Wilhelm, Márta

doi:10.3390/ijerph182312389

Cited by 35 publications

(26 citation statements)

References 150 publications

(265 reference statements)

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“…In conclusion, the analgesic/anti-nociceptive mechanism of action of caffeine is unclear. However, the effects are more established including improved alertness, cognitive processes, mood, learning and physical performance ( Wikoff et al, 2017 ; Soós et al, 2021 ).…”

Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

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The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of primum non nocere, on the other hand, the promise of heavenly joys if successful divinum est opus sedare dolorem. We briefly summarize the concepts associated with nociceptive pain from nociceptive input (afferents from periphery), modulatory output [descending noradrenergic (NE) and serotoninergic (5-HT) fibers] to local control. The local control is comprised of the “inflammatory soup” at the site of pain origin and synaptic relay stations, with an ATP-rich environment promoting inflammation and nociception while an adenosine-rich environment having the opposite effect. Subsequently, we address the transition from nociceptor pain to neuropathic pain (independent of nociceptor activation) and the process of sensitization and pain chronification (transient pain progressing into persistent pain). Having sketched a model of pain perception and processing we attempt to identify the sites and modes of action of clinically available drugs used in chronic pain treatment, focusing on adjuvant (co-analgesic) medication.

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Section: Clinically Available Drugsmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

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“…Following caffeine consumption, people’s responses vary, with a range of negative, neutral, or positive effects depending on genotype, age, habitual caffeine consumption, training status, CAF source, and gender [ 27 ]. The exact mechanism underlying these differences remains unknown, but body size and body composition could be crucial factors.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences in the Frequency of Positive and Negative Effects after Acute Caffeine Consumption

Domaszewski

2023

Nutrients

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Gender-specific caffeine-related adverse effects should be thoroughly investigated. Sixty-five adult participants were included in the study, 30 men and 35 women (age, 22.5 ± 2.8; body weight, 71.7 ± 16.2 kg; BMI, 23.6 ± 4.4). The participants who were classified as low and moderate caffeine users received 3 mg/kg, and high caffeine users received 6 mg/kg of caffeine in one dose. One hour after ingestion of caffeine and within twenty-four hours, the participants completed a side effect questionnaire. Effects after the ingestion of CAF were divided into two subgroups: negative (muscle soreness, increased urine output, tachycardia and palpitations, anxiety or nervousness, headache, gastrointestinal problems, and insomnia) and positive (perception improvement; increased vigor/activeness). Caffeine ingestion resulted in a statistically significant association between gender and negative effects one hour after ingestion (p = 0.049). Gender and positive effects one hour after ingestion (p = 0.005), and between gender and positive effects within 24 h after ingestion (p = 0.047). There were significant associations between gender and perception improvement (p = 0.032) and gender and increased vigor/activeness (p = 0.009) one hour after ingestion. Nearly 30% of men and 54% of women reported negative effects. At the same time, 20% of women and more than 50% of men reported positive effects. Gender is an important factor in the negative and positive effects of caffeine consumption.

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“…Some of the most concerning, and potentially damaging public health ones, include the increased probability and risks from childhood obesity, the increased probability in the rise of early onset cardiovascular pathophysiological conditions, suicidal ideation, and tendency, as well as impaired cognitive function in children (Usman and Jawaid 2012;Kammerer et al 2014;Park et al 2016). In addition to these health risks, aggressive behaviour and mood disorders were reported in a study and linked to caffeine consumption in 15 -16 years olds (Soós et al 2021). Due to their potential effect of enhancing physical performance, EDs have become increasingly appealing and popular to sport athletes.…”

Section: Introductionmentioning

confidence: 99%

Health risks associated with the chronic consumption of energy drinks in children and adolescents

Mphahlele

Ngqwala

Ambang

et al. 2023

Nova Biotechnol. Chim.

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Energy drinks (EDs) have been available at the global market for almost 100 years and today, they are advertised as ’tools’ boost energy, enhance physical performance and mental alertness. Some of the main chemical components in EDs include caffeine, ginseng, and taurine. The market and consumption of these beverages is growing exponentially, and this is becoming a public health problem due to the adverse effects associated with these drinks. The main objective of this article is to review important ingredients in popular EDs in South Africa and look at their molecular mechanisms of action and interaction with other compounds within the body. At the same time, the authors aim to review the global consumption pattern of EDs among children and adolescents. Finally, this review article will provide an overview the health risks associated with EDs consumption. A literature review was conducted using scholarly databases. Keywords such as energy drinks, adverse effects, advertising, alcohol, caffeine, taurine, and regulations were used. Despite the claims of having significant benefits to mental and physical stamina, long-term consumption of EDs could have detrimental public health implications; and could result in increasing rates of the central nervous system disorders and the cardiovascular complications. A knowledge gap exists on how the lack of education impacts the decision of consumers of EDs and the parental guidance provided to children and adolescents in relation to the consumption of these beverages in South Africa. To address the issue of excessive ED consumption, communities need to be made aware of the harmful effects of these beverages through health education and implementing strict regulatory measures through policy.

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Effects of Caffeine and Caffeinated Beverages in Children, Adolescents and Young Adults: Short Review

Cited by 35 publications

References 150 publications

Neuropathic pain: Mechanisms and therapeutic strategies

Neuropathic pain: Mechanisms and therapeutic strategies

Gender Differences in the Frequency of Positive and Negative Effects after Acute Caffeine Consumption

Health risks associated with the chronic consumption of energy drinks in children and adolescents

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