Effects of caffeine on sleep and cognition

Snel, J.; Lorist, Monicque M.

doi:10.1016/b978-0-444-53817-8.00006-2

Cited by 156 publications

(111 citation statements)

References 42 publications

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“…Prior studies have found similar results in other university settings 19, 29, 41–43 . College marks the beginning of new and stressful changes: increased academic workload, busier social lives, and later bed times 4, 5 .…”

Section: Discussionsupporting

confidence: 75%

Daytime sleepiness, circadian preference, caffeine consumption and use of other stimulants among Thai college students

Tran¹,

Lertmaharit²,

Lohsoonthorn³

et al. 2014

J. Public Health Epidemiol.

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We conducted this study to evaluate the prevalence of daytime sleepiness and evening chronotype, and to assess the extent to which both are associated with the use of caffeinated stimulants among 3,000 Thai college students. Demographic and behavioral characteristics were collected using a self-administered questionnaire. The Epworth Sleepiness Scale and the Horne and Ostberg Morningness-Eveningness Questionnaire were used to evaluate prevalence of daytime sleepiness and circadian preference. Multivariable logistic regression models were used to evaluate the association between sleep disorders and consumption of caffeinated beverages. Overall, the prevalence of daytime sleepiness was 27.9 % (95% CI: 26.2–29.5%) while the prevalence of evening chronotype was 13% (95% CI: 11.8–14.2%). Students who use energy drinks were more likely to be evening types. For instance, the use of M100/M150 energy drinks was associated with a more than 3-fold increased odds of evening chronotype (OR 3.50; 95% CI 1.90–6.44), while Red Bull users were more than twice as likely to have evening chronotype (OR 2.39; 95% CI 1.02–5.58). Additionally, those who consumed any energy drinks were more likely to be daytime sleepers. For example, Red Bull (OR 1.72; 95% CI 1.08–2.75) or M100/M150 (OR 1.52; 95% CI 1.10–2.11) consumption was associated with increased odds of daytime sleepiness. Our findings emphasize the importance of implementing educational and prevention programs targeted toward improving sleep hygiene and reducing the consumption of energy drinks among young adults

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Section: Discussionsupporting

confidence: 75%

Daytime sleepiness, circadian preference, caffeine consumption and use of other stimulants among Thai college students

Tran¹,

Lertmaharit²,

Lohsoonthorn³

et al. 2014

J. Public Health Epidemiol.

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“…Recent experimental evidence suggests that the primary target for the neuroprotective effects of caffeine (Glade, 2010; Snel and Lorist, 2011), the most consumed psychostimulant in the world (Nehlig et al, 1992), is mostly through either the activation or inhibition of the A1 and A2a adenosine receptor subtypes (Doré et al, 2011; Sebastião and Ribeiro, 2009) (Table 1; includes earlier findings not discussed in this review). The use of adenosine receptor antagonists, such as caffeine, and agonists has been shown to protect against neurological diseases such as spinal cord injury, stroke, Alzheimer's and Parkinson's diseases (Fig.…”

Section: Discussionmentioning

confidence: 99%

Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

2014

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Caffeine is the most consumed pychostimulant in the world, and it is known to affect basic and fundamental human processes such as sleep, arousal, cognition and learning and memory. It works as a nonselective blocker of adenosine receptors (A1, A2a, A2b and A3) and has been related to the regulation of heart rate, the contraction/relaxation of cardiac and smooth muscles, and the neural signaling in the central nervous system (CNS). Since the late 1990s, studies using adenosine receptor antagonists, such as Caffeine, to block the A1 and A2a adenosine receptor subtypes have shown to reduce the physical, cellular and molecular damages caused by a spinal cord injury (SCI) or a stroke (cerebral infarction) and by other neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. Interestingly, other studies using adenosine receptor agonists have also shown to provide a neuroprotective effect on various models of neurodegenerative diseases through the reduction of excitatory neurotransmitter release, apoptosis and inflammatory responses, among others. The seemingly paradoxical use of both adenosine receptor agonists and antagonists as neuroprotective agents has been attributed to differences in dosage levels, drug delivery method, extracellular concentration of excitatory neurotransmitters and stage of disease progression. We discuss and compare recent findings using both antagonists and agonists of adenosine receptors in animal models and patients that have suffered spinal cord injuries, brain strokes, and Parkinson's and Alzheimer's diseases. Additionally, we propose alternative interpretations on the seemingly paradoxical use of these drugs as potential pharmacological tools to treat these various types of neurodegenerative diseases.

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“…The administration of moderate (1-4 mg/kg) doses of caffeine reliably produces mild stimulant effects, such as enhancing subjective ratings of stimulation and wakefulness while decreasing ratings of mental fatigue. 1,6,7 Caffeine is more effective in enhancing feelings of stimulation in individuals who are fatigued. 7,8 Energy products are also advertised to improve mental functioning, which is also partially supported by the literature.…”

Section: Introductionmentioning

confidence: 99%

“…1,6,7 Caffeine is more effective in enhancing feelings of stimulation in individuals who are fatigued. 7,8 Energy products are also advertised to improve mental functioning, which is also partially supported by the literature. Moderate doses of caffeine and energy drinks can improve some, but not all, aspects of cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

Marczinski

Stamates

Ossege

et al. 2014

Journal of Caffeine Research

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Background: Energy drinks and energy shots are popular consumer beverages that are advertised to increase feelings of alertness. Typically, these products include high levels of caffeine, a mild psychostimulant drug. The scientific evidence demonstrating the specific benefits of energy products to users in terms of subjective state and objective performance is surprisingly lacking. Moreover, there are rising health concerns associated with the use of these products. Therefore, the purpose of this study was to investigate the acute effects of a popular energy shot (5-Hour Energy Ò ) on subjective and objective measures that were assessed hourly for 6 hours following consumption. Methods: Participants (n = 14) completed a three-session study where they received the energy shot, a placebo control, and no drink. Following dose administration, participants completed subjective Profile of Mood States ratings hourly for 6 hours. Participants also repeatedly completed a behavioral control task (the cued go/no-go task) and provided blood pressure and pulse rate readings at each hour. Results: Consumption of the energy shot did improve subjective state, as measured by increased ratings of vigor and decreased ratings of fatigue. However, the energy shot did not alter objective performance, which worsened over time. Importantly, the energy shot elevated both systolic and diastolic blood pressure. Conclusions: Consumption of one energy shot may only result in modest benefits to subjective state. Individuals with preexisting hypertension or other medical conditions should be cautious about using these new consumer products.

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Effects of caffeine on sleep and cognition

Cited by 156 publications

References 42 publications

Daytime sleepiness, circadian preference, caffeine consumption and use of other stimulants among Thai college students

Daytime sleepiness, circadian preference, caffeine consumption and use of other stimulants among Thai college students

Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

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