Effects of calcitriol on eosinophil activity and antibody responses in patients with schistosomiasis

Snyman, J. R.; Sommers, K. De; Steinmann, Myriam; Lizamore, D. J.

doi:10.1007/s002280050289

Cited by 25 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Specific, anti-parasite IgG and/or IgG 4 can be found in urine samples of individuals infected with Wuchereria bancropti, Leishmania, Cryptosporidium parvum, schistosomes or Fasciola, although, compared with urine levels, the serum levels of such immunoglobulins tend to be more closely correlated with parasite burden (Gryseels et al, 1995;Pospisilova et al, 1997;Ramzy et al, 1997;Snyman et al, 1997;Itoh et al, 2001). The mechanism of IgG release into the urine is unknown.…”

Section: Discussionmentioning

confidence: 93%

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand

Tesana

Srisawangwong

Sithithaworn

et al. 2007

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

The levels of correlation between the number of Opisthorchis viverrini eggs excreted in the faeces and levels of anti-Opisthorchis IgG and IgG(4) in the serum and urine (as indicated by absorbances in ELISA) have recently been evaluated in north-eastern Thailand. The 225 subjects investigated in detail, all of whom came from an endemic village in Chaiyaphum province, were selected on the basis of the numbers of O. viverrini eggs that they were excreting. ELISA based on a crude antigen extract of the trematode were then used to determine the levels of specific IgG and IgG(4) in serum and urine samples. Compared with the egg-negative, the villagers who were found to be egg-positive for O. viverrini had significantly higher levels of specific IgG in their urine and serum and significantly higher levels of specific IgG(4) in their serum. The serum levels of specific IgG and IgG(4) and the urine levels of specific IgG all correlated with the numbers of O. viverrini eggs/g faeces [with correlation coefficients (r) of 0.251, 0.121 and 0.142, respectively]. Although the serum levels of IgG were positively correlated with the urine levels of IgG (r=0.098), there was no significant relationship between the serum and urine levels of specific IgG(4) (r=0.051). When the 225 subjects investigated in the ELISA were divided according to whether they had no detectable Opisthorchis eggs in their faeces (N=57), or 1-100 (N=154), 101-1000 (N=5), 1001-1500 (N=5) or >1501 (N=4) eggs/g faeces, the serum and urine levels of specific IgG and the serum (but not urine) levels of specific IgG4 were also found to correlate significantly with the infection-intensity categories (with r-values of 0.550, 0.146 and 0.578, respectively). When the results of the faecal examinations were treated as the 'gold standard', the ELISA for the detection of (Opisthorchis-specific) serum IgG, serum IgG(4), urine IgG and urine IgG(4) had sensitivities of 99.2%, 23.1%, 43.0% and 45.9% and specificities of 93.0%, 29.6%, 45.9% and 67.2%, respectively. Although the study was limited by the small number of subjects with intense infections, it appears worth investigating urine samples for subclasses of specific IgG other than IgG(4).

show abstract

Section: Discussionmentioning

confidence: 93%

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand

Tesana

Srisawangwong

Sithithaworn

et al. 2007

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

show abstract

“…It should be noted that, in four of the other 11 studies that did not find association, the comparison was between HIV-1-associated disease states, such as HIV-1 vs. HIV-1-cryptococcal meningitis [63], rather than between disease vs. healthy control, and vitamin D deficiency was present in 42%–74% of the HIV-1 infected persons. The significant inverse correlation between disease presentation and 25(OH)D levels was more prevalent in studies conducted in southern and western provinces where, due to the higher latitude in the south and lower altitude in the south and west compared with the central/northern Highveld, there is less solar UV-B radiation in the winter months, and thus the likelihood of seasonal deficiency is greater (Figure 1).…”

Section: Association Of Vitamin D Status With Diseases In South Afmentioning

confidence: 99%

Vitamin D Status and Its Consequences for Health in South Africa

Norval

Coussens

Wilkinson

et al. 2016

IJERPH

View full text Add to dashboard Cite

In this review, reports were retrieved in which vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups with varied skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient [25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A major role for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent, with the dietary contribution being minor. Limited data exist regarding the impact of recent changes in lifestyles on vitamin D status, such as urbanisation. With regard to disease susceptibility, 11 of 22 relevant publications indicated association between low 25(OH)D levels and disease, with deficiency most notably found in individuals with tuberculosis and HIV-1. Information on the relationship between vitamin D receptor variants and ethnicity, disease or treatment response in the South African population groups demonstrated complex interactions between genetics, epigenetics and the environment. Whether vitamin D plays an important role in protection against the range of diseases that currently constitute a large burden on the health services in South Africa requires further investigation. Only then can accurate advice be given about personal sun exposure or dietary vitamin D supplementation.

show abstract

“…Adams JS et al [26] Increased Snyman et al [29] Positive effects on levels of activated eosinophils and Schistosomaspecific antibodies…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

Non Calcaemic & Non Osteogenic Functions of Vitamin D: A Brief Review

Behera

2018

MOJAP

View full text Add to dashboard Cite

Vitamin D insufficiency affects almost 50% of the population worldwide. This can mainly be attributed to lifestyle (for example, reduced outdoor activities, liberal use of sunscreen) and environmental (for example, air pollution) factors that reduce exposure to sunlight, which is vital for ultraviolet-B (UVB)-induced vitamin D production. Vitamin D deficiency is common in all age groups. High prevalence of vitamin D insufficiency is a particularly important public health issue as Hypovitaminosis-D is an independent risk factor for several non communicable & communicable diseases. Current studies suggest that we may need more vitamin D than presently recommended to prevent chronic disease like Diabetes & Hypertension. Present review focuses on the non-calcemic and non-osteogenic role of Vitamin D and how Vitamin D deficiency might be an important risk factor in increased disease incidence & prevalence.

show abstract

Effects of calcitriol on eosinophil activity and antibody responses in patients with schistosomiasis

Cited by 25 publications

References 15 publications

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand

Vitamin D Status and Its Consequences for Health in South Africa

Non Calcaemic & Non Osteogenic Functions of Vitamin D: A Brief Review

Contact Info

Product

Resources

About

Effects of calcitriol on eosinophil activity and antibody responses in patients with schistosomiasis

Cited by 25 publications

References 15 publications

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG4in samples of human urine and serum from an endemic area of north–eastern Thailand

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG4in samples of human urine and serum from an endemic area of north–eastern Thailand

Vitamin D Status and Its Consequences for Health in South Africa

Non Calcaemic & Non Osteogenic Functions of Vitamin D: A Brief Review

Contact Info

Product

Resources

About

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand

The ELISA-based detection of anti-Opisthorchis viverriniIgG and IgG₄in samples of human urine and serum from an endemic area of north–eastern Thailand