Effects of Cancer Chemotherapeutic Agents on the Human Fetus

Sokal, Joseph E.; Lessmann, Ellen M.

doi:10.1001/jama.1960.63020160002008

Cited by 146 publications

(3 citation statements)

References 3 publications

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“…Data regarding long-term outcomes of individuals exposed to chemotherapy during intrauterine life are also limited, but the few studies available showed that those individuals have normal growth and development (Table 2) [32, 34-38].…”

Section: Systemic Treatmentmentioning

confidence: 99%

Cancer During Pregnancy: The Oncologist Overview

et al. 2019

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Although a rare and challenging condition, cancer during pregnancy should promptly be identified and treated. Not only standards of care guidelines for the underlying disease are taken into account, but also fetal safety might be weighted for clinical decisions. Frequent lack of experience and knowledge about this condition could lead to late diagnosis, imprecise management, suboptimal treatment and fetal and maternal harm. Therefore, this review aims to summarize the current evidence regarding the epidemiology, clinical presentation, diagnostic workup, staging and treatment, including novel treatment modalities for patients diagnosed with cancer during pregnancy.

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Section: Systemic Treatmentmentioning

confidence: 99%

Cancer During Pregnancy: The Oncologist Overview

et al. 2019

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“…The infant weighed 3 lb and had multiple developmental defects including corneal opacities, cleft palate, microphthalmia and ovarian and thyroid hypoplasia. Sokal & Lessmann (1960) have reviewed all the reports on the effects of the administration of chemotherapeutic agents on the foetus, and have pointed out that the abnormalities described by Diamond have not been recorded when either busulphan or mercaptopurine was the only drug administered. They believe that the drastic effect might have been due to a synergistic action of the two drugs, but they stress the fact that the mother received treatment during the first three months of pregnancy, and that foetal damage did not occur when combinations of other drugs were administered later in the pregnancy.…”

Section: Influence Of Treatment On the Feetusmentioning

confidence: 99%

The Management of Leukæmia in Pregnancy

Galton

1962

Proceedings of the Royal Society of Medicine

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“…Cytotoxic drugs are known to be teratogenic and given the mechanisms of their action that can inhibit the growth of tumors by killing actively growing cells, they can also interference with cell division and cell formation in the fetus. Data on therapeutic exposure to these drugs indicate that pregnant women are most susceptible to fetal loss and teratogenicity effects of these agents during the first trimester, a time of rapid cell division and differentiation in the embryo/fetus [6,7]. …”

Section: Introductionmentioning

confidence: 99%

A Study of Handling Cytotoxic Drugs and Risk of Birth Defects in Offspring of Female Veterinarians

Shirangi

Bower

Holman

et al. 2014

IJERPH

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We examined the association of occupational exposure to handling cytotoxic drugs at work with risk of birth defects among a cohort of female veterinarians. This study is a follow up survey of 321 female participants (633 pregnancies) who participated in the Health Risks of Australian Veterinarian project. Data on pregnancies and exposure during each pregnancy was obtained by self-administered mailed questionnaire. Female veterinarians handling cytotoxic drugs during their pregnancy had a two-fold increased risk of birth defects in their offspring (RR = 2.08, 95% CI (1.05–4.15)). Results were consistent in subgroup analysis of those who graduated during the period of 1961 to 1980 (RR = 5.04, 95% CI (1.81, 14.03) and in those working specifically in small and large animal practice. There was no increased risk in the subgroup that graduated after 1980. Women with unplanned pregnancies were more likely to handle cytotoxic drugs on a daily basis (RR = 1.86, 95% CI, 1.00–3.48) and had a higher increased risk of birth defects than those who planned their pregnancies in recent graduates and in those who worked specifically in small animal practice (RR = 2.53, 95% CI, 1.18–5.42). This study suggests that the adverse effects of handling cytotoxic drugs in pregnant women may include an increased risk of birth defects. Pregnancy intention status is an important health behavior and should be considered in prenatal programs.

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Effects of Cancer Chemotherapeutic Agents on the Human Fetus

Cited by 146 publications

References 3 publications

Cancer During Pregnancy: The Oncologist Overview

Cancer During Pregnancy: The Oncologist Overview

The Management of Leukæmia in Pregnancy

A Study of Handling Cytotoxic Drugs and Risk of Birth Defects in Offspring of Female Veterinarians

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