Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Mamber, Stephen W.; Gurel, Volkan; Lins, Jeremy; Ferri, Fred F.; Beseme, Sarah; McMichael, John

doi:10.1186/s42238-019-0014-9

Cited by 11 publications

(9 citation statements)

References 97 publications

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“…This gene has also been reported to be differentially expressed in airway tissues and participates in the inflammatory response in lung and airway tissues during the pathogenesis of asthma ( Sangaphunchai et al, 2020 ). It has been directly reported to be functionally correlated with IL-13 ( Higham et al, 2020 ; Min et al, 2020 ) and IL-17 ( Kamijo et al, 2020 ; Mamber et al, 2020 ) in focal regions surrounding airway smooth muscles at the transcriptomics level and is further pathologically correlated with several chronic lung diseases, including chronic obstructive pulmonary diseases ( Min et al, 2020 ). Therefore, given its functional correlation with the potential regulatory effects of IL-13 and IL-17 on airway smooth muscle inflammation, the predicted gene CCL26 is definitely an effective signature for cell classification on the transcriptomics level.…”

Section: Discussionmentioning

confidence: 99%

Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles

Zhang

Zeng

et al. 2021

Front. Genet.

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Smooth muscles are a specific muscle subtype that is widely identified in the tissues of internal passageways. This muscle subtype has the capacity for controlled or regulated contraction and relaxation. Airway smooth muscles are a unique type of smooth muscles that constitute the effective, adjustable, and reactive wall that covers most areas of the entire airway from the trachea to lung tissues. Infection with SARS-CoV-2, which caused the world-wide COVID-19 pandemic, involves airway smooth muscles and their surrounding inflammatory environment. Therefore, airway smooth muscles and related inflammatory factors may play an irreplaceable role in the initiation and progression of several severe diseases. Many previous studies have attempted to reveal the potential relationships between interleukins and airway smooth muscle cells only on the omics level, and the continued existence of numerous false-positive optimal genes/transcripts cannot reflect the actual effective biological mechanisms underlying interleukin-based activation effects on airway smooth muscles. Here, on the basis of newly presented machine learning-based computational approaches, we identified specific regulatory factors and a series of rules that contribute to the activation and stimulation of airway smooth muscles by IL-13, IL-17, or the combination of both interleukins on the epigenetic and/or transcriptional levels. The detected discriminative factors (genes) and rules can contribute to the identification of potential regulatory mechanisms linking airway smooth muscle tissues and inflammatory factors and help reveal specific pathological factors for diseases associated with airway smooth muscle inflammation on multiomics levels.

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Section: Discussionmentioning

confidence: 99%

Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles

Zhang

Zeng

et al. 2021

Front. Genet.

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“…Phytocannabinoids. Phytocannabinoids derived from Cannabis sativa, such as cannabidiol (CBD) and 9-tetrahydrocannabinol (THC), have been shown to inhibit inflammatory and Th1 cytokines and/or promote anti-inflammatory and Th2 immune responses both in vitro and in vivo (27)(28)(29). As COVID-19 represents a respiratory disease with a dominant Th1 and inflammatory immune response profile, it has been postulated that cannabinoids represent a class of compounds with the potential to alleviate COVID-19 symptoms and severity by helping to decrease inflammation and restore a Th1/Th2 balance in the immune system.…”

mentioning

confidence: 99%

“…There were also certain genes involved in mucus overproduction or hypersecretion that were downregulated. These included the CLCA1 gene (encoding chloride channel accessory 1) and the CMA1 gene (encoding mast cell chymase 1) (29). Preliminary in vivo testing in Caribbean vervet monkeys (Chlorocebus aethiops sabaeus) indicated that the oil extract improved inspiratory lung functions (J. Osborn, University of Kentucky, unpublished data).…”

mentioning

confidence: 99%

Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

Mamber

Krakowka

Osborn

et al. 2020

mSphere

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Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines, including interleukin-1 (IL-1), IL-6, CCL2 protein, and CXCL10 protein. In the absence of proven antiviral agents or an effective vaccine, substances with immunomodulatory activity may be able to inhibit inflammatory and Th1 cytokines and/or yield an anti-inflammatory and/or Th2 immune response to counteract COVID-19 symptoms and severity. This report briefly describes the following four unconventional but commercially accessible immunomodulatory agents that can be employed in clinical trials to evaluate their effectiveness at alleviating disease symptoms and severity: low-dose oral interferon alpha, microdose DNA, low-dose thimerosal, and phytocannabinoids.

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“…Phytocannabinoids derived from Cannabis sativa, such as cannabidiol (CBD) and 9tetrahydrocannabinol (THC) have been shown to inhibit inflammatory and Th1 cytokines and/or promote an anti-inflammatory and Th2 immune response both in vitro and in vivo(23)(24)(25). As COVID-19 represents a respiratory disease with a dominant Th1 and inflammatory immune response profile, it has been postulated that cannabinoids represent a class of compounds with the potential to alleviate COVID-19 symptoms and severity by helping to decrease inflammation and restore a Th1/Th2 balance in the immune system.…”

mentioning

confidence: 99%

“…There were also certain genes involved in mucus overproduction or hypersecretion that were downregulated. These included CLCA1 (encoding chloride channel accessory 1) and CMA1(encoding mast cell chymase 1)(25). Preliminary in vivo testing in Caribbean Vervets (Chlorocebus aethiops sabaeus) indicated that the oil extract improved inspiratory lung functions (J. Osborn, University of Kentucky, manuscript in preparation).…”

mentioning

confidence: 99%

Could Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

Mamber¹,

Krakowka²,

Osborn³

et al. 2020

Preprint

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Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2 or SARS-CoV2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV2 induce an increase in a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines including interleukins IL-1, IL-6, CCL2 protein and CXCL10 protein. In the absence of proven antiviral agents or an effective vaccine, substances with immunomodulatory activity may be able to inhibit inflammatory and Th1 cytokines and/or yield an anti-inflammatory and/or Th2 immune response to counteract COVID-19 symptoms and severity. This report briefly describes four unconventional but commercially accessible immunomodulatory agents that could be employed in clinical trials to evaluate their effectiveness at alleviating disease symptoms and severity: Low-dose oral interferon-alpha, microdose DNA, low-dose thimerosal and phytocannabinoids.

show abstract

Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Cited by 11 publications

References 97 publications

Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles

Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles

Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

Could Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

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