Effects of Capsaicin and Isoflavone on Blood Pressure and Serum Levels of Insulin-Like Growth Factor-I in Normotensive and Hypertensive Volunteers with Alopecia

Harada, Naoaki; Okajima, Kenji

doi:10.1271/bbb.80883

Cited by 26 publications

(22 citation statements)

References 25 publications

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“…Soy bean drinks are rich in isoflavones, and the isoflavone metabolite equol displays high levels of antioxidant [38], [39], [40] and estrogen-like activities [38], [41], [42], [43]. There are many reports that isoflavone [44], [45], antioxidants [46] and estrogens [43], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58] are protective against alopecia. The previous reports found that orally administered soymetide-4 (MITL), a soy-derived immunostimulating peptide from soy bean beta-conglycinin alpha' subunit, suppressed the alopecia induced by the anti-cancer drug etoposide [52], [59], [60], [61], [62].…”

Section: Discussionmentioning

confidence: 99%

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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BackgroundAlthough the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.ObjectiveThis study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA).DesignAge, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs) indicating association with moderate to severe AGA (≧IV). Subsequently, Hosmer-Lemeshow, Nagelkerke R2 and accuracy tests were conducted to help establish an optimal model.ResultsModerate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99–126.83), blood vanadium concentration (0.02, 95% CI 0.01–0.04), and regular consumption of soy bean drinks (0.23, 95% CI 0.06–0.85), after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73), Nagelkerke R2 (0.59), accuracy test (0.816) and area under the curve (AUC; 0.90, 0.847–0.951) analysis.ConclusionsBlood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.

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Section: Discussionmentioning

confidence: 99%

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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“…Experimental observations strongly suggest that the combination of capsaicin and isoflavone, two bioactive compounds included in the crop, significantly increase IGF-I production in HF, promoting HG [103,104]. In particular, capsaicin binds to transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the vanilloid receptor 1, increasing the release of calcitonin peptide (CGRP) from sensory neurons and finally raising IGF-I production [105]. Intradermal injection of capsaicin induces anagen phase in mice [105].…”

Section: Rosmarinus Officinalis L Cellular Models Authors and Year Rmentioning

confidence: 99%

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Bassino

Gasparri

Munaron

2020

IJMS

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Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption.

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“…There are also inferred connections between icariin and hypertension via IGF1 . Myocardial ischemia, lack of oxygen supply to the heart by partial or complete blockage, is, among other genes, related to IGF1 expression.…”

Section: Prominent Genes Affected By Icariin and Linked To Geriatric mentioning

confidence: 99%

Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis

Schluesener

2013

Molecular Nutrition Food Res

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Polyphenols are a broad class of compounds. Some are ingested in substantial quantities from nutritional sources, more are produced by medicinal plants, and some of them are taken as drugs. It is becoming clear, that a single polyphenol is impacting several cellular pathways. Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age-related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like PDE, TGF-ß, MAPK, PPAR, NOS, IGF, Sirtuin, and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.

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Effects of Capsaicin and Isoflavone on Blood Pressure and Serum Levels of Insulin-Like Growth Factor-I in Normotensive and Hypertensive Volunteers with Alopecia

Cited by 26 publications

References 25 publications

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review

Plant polyphenols in the treatment of age‐associated diseases: Revealing the pleiotropic effects of icariin by network analysis

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