Effects of Captopril Chronic Intake on the Aerobic Performance and Muscle Strength of Normotensive Trained Subjects

Carré, François; Handschuh, Robert F.; Beillot, J.; Dassonville, J.; Rochcongar, P.; Ph, Guivarc'h; Lessard, Yvon

doi:10.1055/s-2007-1021272

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…One small study suggested that ACE inhibitors have no effect on heart rate and minimal effect on V O 2max (10). The well-documented adverse effect of ACE inhibitor use of dry cough, which occurs in approximately 10% of patients (27), may require an alternate antihypertensive choice in certain athletes with hypertension.…”

Section: Antihypertensive Medicinesmentioning

confidence: 99%

Cardiovascular Considerations in Middle-Aged Athletes at Risk for Coronary Artery Disease

Reamy

Ledford²

2013

Current Sports Medicine Reports

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Cardiovascular disease remains the leading cause of death in the United States despite a 50% decrease in deaths from myocardial infarction and stroke in the past 30 years associated with improvements in blood pressure and lipid control. The National Health and Nutrition Evaluation Survey found that the least prevalent metrics of cardiovascular health in adults were healthy diets, normal weights, and optimal levels of exercise. A further reduction in rates of cardiovascular disease will require an increase in exercise. Clinicians who encourage exercise in middle-aged patients face several dilemmas. This article reviews exercise-related risks for sudden death and the performance of a global cardiovascular risk assessment. The need for additional preexercise risk stratification with electrocardiogram, graded exercise testing, or echocardiography is outlined. In addition, the optimum choice of medications for hypertension or dyslipidemia treatment and the effects of these medications and aspirin on endurance exercise are reviewed.

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Section: Antihypertensive Medicinesmentioning

confidence: 99%

Cardiovascular Considerations in Middle-Aged Athletes at Risk for Coronary Artery Disease

Reamy

Ledford²

2013

Current Sports Medicine Reports

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“…Caution is required in extrapolating findings in rodents to a completely different species, the human. Several studies have shown that ACE inhibitors increase exercise capacity in patients with heart failure [58] , however, in contrast, some studies have instead found little or no improvement in older people with diastolic heart failure [59] or healthy younger athletes [60] . Sulfhydryl-containing ACE inhibitors give higher protection against atherogenesis than other ACE inhibitors [61] .…”

Section: Clinical Studies With Ace Inhibitorsmentioning

confidence: 99%

Sarcopenia – A Potential Target for Angiotensin-Converting Enzyme Inhibition?

Sumukadas

Struthers²,

McMurdo³

2006

Gerontology

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Society is ageing. There has been a steady increase in the number of people aged 65 years and over throughout the 20th century and this trend is predicted to continue worldwide. This has resulted in an increase in the incidence of sarcopenia, which is a loss of muscle mass and function with age. Maintenance of muscular function into old age is critical to sustaining normal daily activity and functional independence. Sarcopenia is associated with increased morbidity and mortality. Till now most efforts to counteract sarcopenia have met with limited success. We postulate that targeting the renin-angiotensin system through angiotensin-converting enzyme (ACE) inhibition could play a role in countering sarcopenia. ACE inhibitors could work by preventing mitochondrial decline and improving endothelial function and muscle metabolism. We describe the literature to support our hypothesis that sarcopenia may be a potential therapeutic target for ACE inhibitors.

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Hypertension in Athletes and Active Populations

2016

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Hypertension continues to be the most common cardiovascular disorder in the USA and worldwide. While generally considered a disorder of aging individuals, hypertension is more prevalent in athletes and the active population than is generally appreciated. The timely detection, diagnosis, and appropriate treatment of hypertension in athletes must focus on both adequately managing the disorder and ensuring safe participation in sport while not compromising exercise capacity. This publication focuses on appropriately diagnosing hypertension, treating hypertension in the athletic population, and suggesting follow-up and participation guidelines for athletes.

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Effects of Captopril Chronic Intake on the Aerobic Performance and Muscle Strength of Normotensive Trained Subjects

Cited by 8 publications

References 9 publications

Cardiovascular Considerations in Middle-Aged Athletes at Risk for Coronary Artery Disease

Cardiovascular Considerations in Middle-Aged Athletes at Risk for Coronary Artery Disease

Sarcopenia – A Potential Target for Angiotensin-Converting Enzyme Inhibition?

Hypertension in Athletes and Active Populations

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