Effects of cardiac glycosides on 24‐h ambulatory blood pressure in healthy volunteers and patients with heart failure

Abstract

Blood pressure effects of cardiac glycosides in humans have been infrequently reported. Although direct infusion of ouabain or digoxin causes vasoconstriction, indirect effects of cardiac glycosides may have the opposite effect, owing to changes in sympatho‐vagal balance. This paper summarises three studies on the effects of cardiac glycosides on circadian blood pressure, utilizing automatic 24‐h ambulatory blood pressure measurement (ABPM). In healthy volunteers, 10 days of oral digoxin or digitoxin caused decreases in diastolic blood pressure and heart rate during overnight sleep. No effect was detectable during daytime activities. In patients with heart failure (NYHA stage II), 7 days of oral digoxin also caused a decrease in diastolic blood pressure but only a small increase in systolic pressure during overnight sleep. Again, no effect was detectable during the day. Cardiac glycosides have significant effects on blood pressure, which only appear during overnight sleep, i.e. a phase when sympathetic background activity is lowest. Regular daytime activities may ‘overwrite’ these effects. Effects of cardiac glycosides on blood pressure may have therapeutic impact, depending on the stage of heart failure and concomitant diseases.

Assessment of the Level of Metal(loid)s Pollution and Bioactive Compounds Screening of Anthill Soil

“…Moreover, they function as neuropharmacological agents [29] [56]. According to a study by Grossman and Kirch [57], cardiac glycosides are known to have antihypertensive properties, given that a particular cardiac glycoside drug (digoxin) demonstrated the ability to lower diastolic blood pressure and heart rate in both normotensive and hypertensive people overnight. This cardiac glycoside is also known to enhance cardiac contractility and induce apoptosis of tumor cells [58].…”

Homeopathy and systematics: a systematic analysis of the therapeutic effects of the plant species used in homeopathy

“…26 In biomedicine, the therapeutic efficacy is confined principally to a small group of drugs that affects the function of the heart directly, and this includes the cardiac glycosides. 27 These glycosides are found distributed in a dozen plant families. [28][29][30] Some of the main genera in these families containing cardiac glycosides include those from the clade in Figure 1.…”