Effects of cardiac resynchronisation therapy on dilated cardiomyopathy with isolated ventricular non-compaction

Bertini, Matteo; Ziacchi, Matteo; Biffi, Mauro; Biagini, Elena; Rocchi, Guido; Martignani, Cristian; Ferlito, Marinella; Pasquale, Ferdinando; Cervi, Elena; Branzi, Angelo; Rapezzi, Claudio; Boriani, Giuseppe

doi:10.1136/hrt.2010.211607

Cited by 62 publications

(48 citation statements)

References 21 publications

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“…On the other hand, the hypertrabeculation phenotype can be observed in heart diseases other than DCM, such as hypertrophic cardiomyopathy [21], congenital heart diseases [22], or neuromuscular disorders [17]. Some authors have suggested that ventricle dilatation and the separation of the inner myocardial layer make trabeculation more visible [23]. Interestingly, in our study mid-wall fibrosis, which is a characteristic feature of DCM, was found less frequently in patients with high degrees of trabeculation.…”

Section: Discussionmentioning

confidence: 39%

Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

Mazurkiewicz¹,

Petryka²,

Śpiewak³

et al. 2017

Kardiol Pol

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A b s t r a c t Background and aim:We sought to search for factors associated with the magnitude of trabeculation by cardiac magnetic resonance, and evaluate the impact of trabeculations on outcomes in patients with dilated cardiomyopathy (DCM). Methods:We evaluated clinical profiles and outcomes of 276 subjects with DCM (age: 33.2 ± 13.3 years, 160 males). Trabeculation was quantified as trabeculated/total myocardial mass ratio (TM/M). Subjects were stratified into three subgroups (A, B, and C) according to the tertiles of rising TM/M values (33% ranges). A group of 30 healthy subjects served as controls. Patients were prospectively followed-up in search of major adverse cardiovascular events for 2.4 years on average (range 0.2-3.9 years).Results: Dilated cardiomyopathy patients had more trabeculation than controls (27.1 ± 16.9% vs. 17.3 ± 8.1, p < 0.01). Group C subjects had lowest N-terminal pro-B-type natriuretic peptide (NT-proBNP) (1445 Conclusions:Trabeculation patterns relate to cardiac function and neurohormonal activation but not to survival.

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Section: Discussionmentioning

confidence: 39%

Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

Mazurkiewicz¹,

Petryka²,

Śpiewak³

et al. 2017

Kardiol Pol

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“…There is some evidence that early initiation of typical HF treatment in LVNC patients with or without clinical symptoms, especially in the beginning of left ventricular dysfunction, could be beneficial and delay fully-expressed HF clinical presentation [2]. Some authors have demonstrated that cardiac resynchronisation therapy can results in improvement of left ventricular function in patients with a dilated left ventricle coexisting with LVNC [1]. Due to the high risk of sudden cardiac death caused by arrhythmias an implantation of cardioverter-defibrillator device (ICD) based on conventional criteria used in HF should be always considered.…”

Section: Discussionmentioning

confidence: 99%

A patient with abnormalities of the coronary arteries and non-compaction of the left ventricular myocardium resulting in ischaemic heart disease symptoms

et al. 2015

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“…Biventricular pacing is a form of cardiac stimulation, referred to as cardiac resynchronization therapy (CRT), that may improve cardiac function in the case of heart failure, low ejection fraction and ventricular dyssynchrony [25]. …”

Section: Cardiac Manifestations Of Laminopathies and Clinical Decisiomentioning

confidence: 99%

“…The beneﬁcial effects of CRT on LV reverse remodeling and systolic function are very clear in dilated cardiomyopathy with LV non compaction, a setting where a high proportion of patients may exhibit a so called ‘super-response’, with the evidence that the greater the area of noncompaction (higher number of non-compacted segments) the greater the chance of achieving a favourable CRT response and greater LV reverse remodeling [25]. …”

Section: Dilated Cardiomyopathymentioning

confidence: 99%

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes

Boriani

Biagini

Ziacchi

et al. 2018

Nucleus

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Lamin A/C gene mutations can be associated with cardiac diseases, usually referred to as ‘cardiolaminopathies’ characterized by arrhythmic disorders and/or left ventricular or biventricular dysfunction up to an overt picture of heart failure. The phenotypic cardiac manifestations of laminopathies are frequently mixed in complex clinical patterns and specifically may include bradyarrhythmias (sinus node disease or atrioventricular blocks), atrial arrhythmias (atrial fibrillation, atrial flutter, atrial standstill), ventricular tachyarrhythmias and heart failure of variable degrees of severity. Family history, physical examination, laboratory findings (specifically serum creatine phosphokinase values) and ECG findings are often important ‘red flags’ in diagnosing a ‘cardiolaminopathy’. Sudden arrhythmic death, thromboembolic events or stroke and severe heart failure requiring heart transplantation are the most dramatic complications of the evolution of cardiolaminopathies and appropriate risk stratification is clinically needed combined with clinical follow-up. Treatment with cardiac electrical implantable devices is indicated in case of bradyarrhythmias (implant of a device with pacemaker functions), risk of life-threatening ventricular tachyarrhythmias (implant of an ICD) or in case of heart failure with wide QRS interval (implant of a device for cardiac resynchronization). New technologies introduced in the last 5 years can help physicians to reduce device-related complications, thanks to the extension of device longevity and availability of leadless pacemakers or defibrillators, to be implanted in appropriately selected patients. An improved knowledge of the complex pathophysiological pathways involved in cardiolaminopathies and in the determinants of their progression to more severe forms will help to improve clinical management and to better target pharmacological and non-pharmacological treatments.

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Effects of cardiac resynchronisation therapy on dilated cardiomyopathy with isolated ventricular non-compaction

Abstract: Patients with IVNC-DCM had greater LV reverse remodelling after CRT than patients with DCM. The greater the area of non-compaction (higher number of IVNC segments) the greater the chance of achieving CRT response and greater LV reverse remodelling.

Cited by 62 publications

References 21 publications

Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

Clinical and prognostic relevancy of left ventricular trabeculation assessed by cardiac magnetic resonance in patients with dilated cardiomyopathy

A patient with abnormalities of the coronary arteries and non-compaction of the left ventricular myocardium resulting in ischaemic heart disease symptoms

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes

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