Effects of Carvacrol in an Experimentally Induced Esophageal Burn Model: Expression of VEGF and Caspase-3 Proteins

Zeytun, Hikmet; Özkorkmaz, Ebru Gökalp

doi:10.1080/08941939.2019.1637484

Cited by 11 publications

(12 citation statements)

References 35 publications

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“…13,14 However, available studies mainly focused on the association between the preoperative TTE abnormality and postoperative complications rather than cardiac complications specifically. 12 In addition, the conclusion of the previous study was still controversial. 13,14 Furthermore, previous studies mainly focused on one type of preoperative TTE abnormality rather than comprehensively evaluating multiple TTE abnormalities at the same time.…”

Section: Introductionmentioning

confidence: 99%

“…Preoperative transthoracic echocardiography (TTE) is frequently considered in elderly patients with hip fracture, because it is a reliable tool to assess cardiac structural and functional abnormality. 11 So far, only few studies have shown preoperative TTE abnormality as the predictor of postoperative complications and mortality after hip fracture, including mild pericardial effusion, 12 aortic stenosis (AS). 13,14 However, available studies mainly focused on the association between the preoperative TTE abnormality and postoperative complications rather than cardiac complications specifically.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Furthermore, previous studies mainly focused on one type of preoperative TTE abnormality rather than comprehensively evaluating multiple TTE abnormalities at the same time. [12][13][14] Therefore, we conducted this study to evaluate the predictive value of different types of cardiac abnormalities, evaluated with preoperative TTE, in cardiac complications and in-hospital mortality in elderly patients after hip fracture surgery.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report

Chen¹,

Ma²,

Deng³

et al. 2020

CIA

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Introduction: Transthoracic echocardiography (TTE) is a common cardiac screening test before hip fracture surgery. However, the general TTE test delays surgery, so it would be meaningful if we could simplify the TTE by only assessing cardiac abnormality specifically. Therefore, we aimed to establish the most clinically relevant abnormality by comparing the predictive value of each major cardiac abnormality in postoperative cardiac complications and mortality in elderly hip fracture patients. Patients and Methods: From January 2014 to January 2019, the medical records of all surgically treated elderly patients (>65 years) with hip fracture were analyzed. The major TTE abnormalities were defined as left ventricular hypertrophy, systolic pulmonary arterial pressure >25 mm Hg, moderate-severe valve abnormality, left ventricular ejection fraction (LVEF) <50%, and pericardial effusion. The outcomes were postoperative cardiac complications and in-hospital mortality. Results: There were 354 patients involved finally. Postoperative cardiac complications were encountered in 7.6% (n=27) of patients. The mortality rate was 2.8% (n=10). History of coronary artery disease (CAD) (OR: 3.281, 95% CI: 1.332-8.079, p=0.010) and presence of aortic stenosis (AS) (OR:5.656, 95% CI: 1.869-17.117, p=0.002) were independent predictors of postoperative cardiac complications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report

Chen¹,

Ma²,

Deng³

et al. 2020

CIA

View full text Add to dashboard Cite

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“…The invasion of tumor cells is a manifestation of the malignant behavior of tumor cells. 36 Colorectal cancer cells have higher biological characteristics of invasion and metastasis. The main factor affecting the treatment effect of colorectal cancer patients is distant metastasis, and liver metastasis is the most common.…”

Section: Discussionmentioning

confidence: 99%

Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling

Huang

Chun-an

Cai

et al. 2020

OTT

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Background: Omega 3 polyunsaturated fatty acid (Omega-3PUFA) is one of the essential nutrients for human body involved in intracellular metabolic regulation and cell signaling. Previous studies have shown that Omega-3PUFA is involved in the pathogenesis of digestive system tumors, including colorectal cancer (CRC), however, the effects of Omega-3PUFA on CRC has not been fully elucidated. In the current study, we evaluated whether Omega-3PUFA can alleviate N-methyl-N-nitrosourea(MNU) induced CRC in a rat model and illustrated the potential mechanism. Methods: The effects of Omga-3PUFA on MNU-induced colorectal cancer in rats were analyzed by in vivo experiments. The viability, apoptosis, colony formation and invasion of CRC cells treated with Omga-3PUFA were detected by CCK8, flow cytometry, clone formation assay and transwell invasion assay. The expression of apoptosis-related proteins in CRC cells treated with Omga-3PUFA was detected by Western blotting. Finally, after adding PI3K activator, the viability, apoptosis and protein expression of CRC cells treated with Omga-3PUFA were detected by CCK8, flow cytometry and Western blotting. Results: Our results showed that Omega-3PUFA attenuated MNU-induced CRC in rats and inhibited AKT/Bcl-2 signaling in rats. In addition, Omega-3PUFA inhibited CRC cell proliferation and induces CRC cell apoptosis. Moreover, Omega-3PUFA inhibited CRC cell colony formation and invasion, and inhibited PI3K/AKT/Bcl-2 signaling in CRC cells. Furthermore, The effects of Omega-3PUFA on cell proliferation and apoptosis were inhibited by blocking PI3K/AKT signaling. Conclusion: Omega-3PUFA can attenuate MNU-induced colorectal cancer in rats by blocking PI3K/AKT/Bcl-2 signaling, which suggests that Omega-3PUFA may be a potent agent for CRC treatment.

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“…Carvacrol is a natural monoterpene derivative and the main component of most essential oils extracted from aromatic plants, including oregano, musk, thyme, and thymus [9,10]. Carvacrol is an approved food additive and has extensive biological effects: anti-inflammatory, immunomodulatory, anti-oxidative stress, anti-tumor, anti-bacteria, anti-apoptosis, and neuron protection [11][12][13][14][15][16][17]. Besides, carvacrol works as a modulator of ion channels.…”

Section: Introductionmentioning

confidence: 99%

Effect of long-term treatment of Carvacrol on glucose metabolism in Streptozotocin-induced diabetic mice

Mai

Qiu

et al. 2020

BMC Complement Med Ther

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Background: Carvacrol is a food additive with various bioactivities, including reducing the blood glucose level as well as improvement of heart function, in diabetic mice. We explored the antihyperglycemic effect of carvacrol and its effect on the key hepatic enzymes accounting for glucose metabolism. Methods: A streptozotocin (STZ)-induced diabetes-mellitus model in mice was used. Mice were divided randomly into a control group, diabetic group, low dose carvacrol-treated diabetic group (10 mg/kg body weight [BW]), and high dose carvacrol-treated diabetic group (20 mg/kg BW). Carvacrol was injected intraperitoneally (i.p.) in each carvacrol-treated group daily for 4 weeks and 6 weeks, respectively. The level of random plasma glucose, fasting plasma glucose, and plasma insulin was determined at 4 weeks and 6 weeks after carvacrol administration. The plasma level of total cholesterol (TC), triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and the activity of hepatic key enzymes related to glucose metabolism were determined. Results: Carvacrol treatment decreased the levels of random plasma glucose and fasting plasma glucose, significantly in a dose-dependent manner. A significant improvement in glucose tolerance and a significant decrease in the plasma level of TG were observed in carvacrol-treated diabetic mice at a dose of 20 mg/kg BW compared with that in vehicle-treated diabetic mice. There was no significant difference in the plasma level of TC and insulin between vehicle-treated diabetic mice and carvacrol-treated diabetic mice. Carvacrol treatment at a dose of 20 mg/kg BW significantly reduced the plasma level of LDH but not AST, ALT, or ALP, compared with that in the vehicle-treated diabetic group. The activity of hexokinase (HK), 6-phosphofructokinase (PFK), and citrate synthetase (CS) was increased by carvacrol treatment in diabetic mice. Conclusions: Carvacrol exerted an anti-hyperglycemic effect in STZ-induced diabetic mice. This was achieved through regulating glucose metabolism by increasing the activity of the hepatic enzymes HK, PFK, and CS.

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Effects of Carvacrol in an Experimentally Induced Esophageal Burn Model: Expression of VEGF and Caspase-3 Proteins

Cited by 11 publications

References 35 publications

<p>Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report</p>

<p>Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report</p>

<p>Omega-3PUFA Attenuates MNU-Induced Colorectal Cancer in Rats by Blocking PI3K/AKT/Bcl-2 Signaling</p>

Effect of long-term treatment of Carvacrol on glucose metabolism in Streptozotocin-induced diabetic mice

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