Effects of Castration, Testosterone Propionate and Exposure to Cold on the Oxygen Uptake of Rat Tissues

Abstract

Oxygen uptake of liver, kidney and brain slices was determined from intact and castrated male rats exposed to cold (2 ± 2°C) and treated with either testosterone propionate or sesame oil. Rats were treated with 1 mg testosterone propionate or 0.1 cc sesame oil daily for periods of 15 and 50 days. Another group of intact and castrated rats were maintained at room temperature (23 ± 2°C) and treated similarly to the animals exposed to cold. The oxygen uptake of the tissue slices was compared to that observed in tissue slices from control rats receiving no treatment. Castration caused an increase in oxygen uptake and treatment with testosterone propionate caused a decrease. Treatment of intact and castrated rats with testosterone propionate during cold exposure resulted in increased oxygen uptake. Sesame oil alone, likewise, resulted in increased oxygen uptake of liver and brain slices from castrated rats treated during cold exposure. The oxygen uptake of kidney slices from castrated rats was not affected by exposure to cold.

Comparison of Systemic and Coronary Hemodynamics in the Normal Human Male and Female

“…18 Consideration must also be given to a body of information concerning the effect of sex hormones on tissue respiration which indicates that testosterone depresses oxygen consumption. 14 ' 15 An inverse relation has been shown between heart weight and myocardial oxygen consumption in the dog heart lung prepara-tion (?• = -0.5421). 16 Intact, unanesthetized dogs showed a similar relation between myocardial oxygen consumption and left ventricular weight (r --0.56) and between left ventricular coronary blood flow and left ventricular weight (»• = -0.68).…”