Effects of CCK‐8 on ingestive behaviors of suckling and weanling rats

Lorenz, Dennis N.

doi:10.1002/dev.420270105

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Using a similar paradigm, this study extends previous findings and demonstrates, for the first time, to our knowledge, that rat pups also develop reduced sensitivity to CCK when chronically eating a HF-diet. Numerous studies have shown that CCK or nutrients that stimulate CCK secretion are effective in reducing food intake in rat pups (9)(10)(11)(12)37). The CCK-1 receptor (CCK-1R) mediates these behavioral effects, because antagonism of the receptor attenuates nutrient-and CCK-induced satiation (12,37).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we examined the relative time course for the development and extinction of reduced sensitivity to CCK-induced satiation in rats fed the HF diet. Rats used in the previous experiment (n = 8/group) adapted to LF and HF diets with mean body weights of 387 6 19.and 389 6 15.6 g, respectively, were fed their respective diets for an additional 3 wk (wk [8][9][10]. During this time (wk 9-10, phase I), the rats were tested for CCK sensitivity (0.25 and 0.5 g/kg) following the same protocol as described above.…”

Section: Dietsmentioning

confidence: 99%

“…Similar to adult rats, rat pups significantly reduce food intake after administration of CCK (9)(10)(11)(12). Overfeeding and feeding of HF diets during the neonatal and postnatal period is associated with alterations in behavioral, neuronal, and metabolic path-ways that perpetuate overconsumption and obesity [see (13) for review].…”

Section: Introductionmentioning

confidence: 99%

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Reduced Sensitivity to Cholecystokinin in Male Rats Fed a High-Fat Diet Is Reversible

Swartz

Savastano

Covașă

2010

The Journal of Nutrition

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Adult rats chronically fed a high-fat (HF) diet maintain reduced sensitivity to cholecystokinin (CCK). We hypothesized that, similar to adult rats, pups fed a HF diet would also exhibit reduced sensitivity to CCK. To test this, male pups fed low-fat (LF) and HF isoenergetic (16.2 kJ/g) diets were administered CCK intraperitoneally (0.125-1 microg/kg) 1 wk following dietary adaptation. After receiving 0.5 microg/kg CCK, pups fed the HF diet suppressed food intake less (8.9 +/- 5.0%) than pups fed the LF diet (28.9 +/- 4.7%; P < 0.05) relative to intakes after saline administration. We then assessed the development and extinction of changes in CCK sensitivity by switching the diets between the groups. The HF-fed group, when switched to the LF diet, regained sensitivity by wk 4 and suppressed food intake following administration of 0.25 microg/kg CCK (33.1 +/- 5.7%; P < 0.05). The LF-fed group, when switched to the HF diet, lost sensitivity by wk 2 and did not suppress food intake after administrations of CCK compared with saline. Finally, we examined if HF-fed rats have an increased sensitivity to corn oil during brief access tests using a multibottle gustometer. At oil concentrations of 25, 75, and 100%, rats fed the HF diet sampled more oil than LF-fed rats (P < 0.05). These findings demonstrate that male rat pups fed a HF diet exhibit reduced sensitivity to CCK, the development of this reduced sensitivity is quicker than its extinction, and rats consuming a HF diet have increased oral sensitivity to oils.

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Section: Discussionmentioning

confidence: 99%

Section: Dietsmentioning

confidence: 99%

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Reduced Sensitivity to Cholecystokinin in Male Rats Fed a High-Fat Diet Is Reversible

Swartz

Savastano

Covașă

2010

The Journal of Nutrition

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“…In addition, there is evidence that both OT and CCK are involved in a variety of regulatory processes in infant rats. Exogenous administration of both CCK (Houpt & Houpt, 1979;Robinson, Moran, & McHugh, 1988) and OT (Nelson & Alberts, 1998, unpublished obs) reduce milk intakeÐalthough the CCK-induced reduction in ingestion is much stronger in the adult feeding mode than in the suckling mode (Lorenz, 1994). Furthermore, both of these substances have been shown to reduce USV emissions (Blass & Shide, 1993;Insel & Winslow, 1991;Weller & Blass, 1988) and to participate in odor preference formation (Nelson & Panksepp, 1996;Weller & Blass, 1988) in suckling rat pups.…”

Section: Discussionmentioning

confidence: 99%

Gastric saline infusion reduces ultrasonic vocalizations and brown fat activity in suckling rat pups

Nelson

Alberts

2002

Developmental Psychobiology

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Under standard conditions involving isolation and cooling, it has been documented that intraoral infusion of milk and injection of the intestinal peptide cholecystokinin (CCK) result in an attenuation in ultrasonic vocalizations (USV) emitted by infant rat pups. One of the most effective stimuli in inhibiting ingestion in suckling rat pups is gastric distension, but the effect of gastric distension on USV production has not been reported. In this experiment, we subjected infant rats to intragastric infusion of isotonic saline (2% body weight) to produce a natural level of gastric distension and hydration. We found that this stimulus resulted in a powerful reduction in USV emissions in isolated 10-day-old rats. In a subsequent experiment, we found that gastric saline infusion also diminished brown adipose tissue (BAT) thermogenesis. There were different time courses of the gastric saline infusion effects on BAT thermogenesis and on USV emissions, however, suggesting that these processes may be independently regulated. We hypothesize that this stimulus induces a transient activation of the parasympathetic nervous system, which overrides the sympathetic control of BAT and USV production.

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“…In experiment one, the high pre-feeding levels of plasma CCK did not prevent the lambs from sucking. Although it has been suggested that CCK might be a factor regulating food intake in the new-born infant (Marchini and Linden, 1992) as it does in the adult (Crawley and Corwin, 1994), there is evidence in animal models that hunger mechanisms are not fully functional in the suckled young or do not involve CCK (Blass et al, 1979;Lorenz, 1994). In any case, CCK is unlikely to be a satiation factor in the young lamb since in experiment two most lambs stopped feeding before any increase was recorded in the plasma.…”

Section: Animalsmentioning

confidence: 99%

Plasma cholecystokinin concentrations in 3-day-old lambs: effect of the duration of fasting preceding a sucking bout

Nowak¹,

Orgeur²,

Piketty³

et al. 1997

Reprod. Nutr. Dev.

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Summary -Cholecystokinin (CCK) is a regulatory peptide released into the circulation after the ingestion of food. Our knowledge concerning the factors affecting its pattern of secretion in the mammalian neonate is scanty. Therefore, in this work we studied plasma concentrations of CCK in 3-dayold lambs after a sucking bout that followed either a short (2 h) or a long fasting period (9 h). Plasma concentrations of CCK were measured by radioimmunoassay in blood samples collected from jugular veins 10 min before, immediately after a sucking bout, and then at 10-min intervals during the following hour. In the first experiment a period of fasting of 2 h before allowing the lambs to suck did not lower the levels of CCK. On the other hand, a significant decrease was recorded 10 min after feeding ended. Between 20 and 50 min after the end of sucking, the mean CCK concentration rose back to the pre-feeding level before decreasing again at 60 min. In the second experiment a period of fasting of 9 h, on the other hand, significantly lowered the levels of CCK. Plasma levels also tended to decrease immediately after sucking was ended. This was followed by a substantial rise and levels remained high during the rest of the sampling period. It was concluded that the decrease recorded immediately after a sucking bout could be due to an inhibitory effect of the oral phase while the following rise reflected the stimulatory effect of milk nutrients on intestinal CCK-producing cells.lamb / new-born / cholecystokinin / sucking / fasting Résumé -Effet de l'intervalle entre tétées sur les concentrations plasmatiques de cholécysto-kinine chez l'agneau nouveau-né. La cholécystokinine (CCK) est un peptide régulateur libéré dans la circulation après une prise alimentaire. La connaissance des facteurs influençant son profil de

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Effects of CCK‐8 on ingestive behaviors of suckling and weanling rats

Cited by 11 publications

References 23 publications

Reduced Sensitivity to Cholecystokinin in Male Rats Fed a High-Fat Diet Is Reversible

Reduced Sensitivity to Cholecystokinin in Male Rats Fed a High-Fat Diet Is Reversible

Gastric saline infusion reduces ultrasonic vocalizations and brown fat activity in suckling rat pups

Plasma cholecystokinin concentrations in 3-day-old lambs: effect of the duration of fasting preceding a sucking bout

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