Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, on Sympathetic Nervous Activity, Body Temperature, Heart Rate, and Blood Pressure in Humans

Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance ThermogenesisviaGastrointestinal TRPV1 in Mice

“…13) This feature of capsinoids may be due their not passing through the gastrointestinal wall. Since capsinoids have weak pungency and are thought not to pass through the gastrointestinal wall, the side-effects by capsinoids are thought to be smaller than those by capsaicin.…”

“…11,12) Furthermore, acute 'CH-19 Sweet' intake enhances sympathetic nervous activity, thermogenesis, and energy expenditure as effectively as hot red pepper in humans. 13,14) A chronic 'CH-19 Sweet' intake reduces body fat and body weight in healthy people, 15) and a chronic capsinoid intake enhances energy expenditure and fat oxidation in obese people. 16) Since 'CH-19 Sweet' (capsinoids) have little pungency, 9) they may be more edible for many people than hot red pepper (capsaicin).…”

Assessment of the Biological Similarity of Three Capsaicin Analogs (Capsinoids) Found in Non-Pungent Chili Pepper (CH-19 Sweet) Fruits

“…26) In a series of studies to evaluate capsinoid safety, Bernard et al 27) that capsinoids were not transferred to the circulation after oral intake in humans due to breakdown of the ester bond by hydrolysis before digestive absorption. But, Hachiya et al 28) reported that oral ingestion of capsicum-containing capsinoids without capsaicinoids (capsaicin or capsaicin analogs with an amide bond) activated the sympathetic nervous system in humans but did not change the blood pressure, whereas capsicum-containing capsaicinoids did. This apparent contradiction raises the question why capsinoids activate the sympathetic nervous system even though they do not enter the bloodstream in an intact form.…”

“…The discrepant findings might be reconciled by the fact that TRPV1 is also expressed on peripheral nerve endings distributed in the gastric mucous membrane. 29) The orally ingested capsinoids in the study of Hachiya et al 28) bound to TRPV1 expressed on the gastric surface and triggered it to activate the sympathetic nervous system.…”

Capsinoids, Non-Pungent Capsaicin Analogs, Reduce Body Fat Accumulation without Weight Rebound unlike Dietary Restriction in Mice

“…11,12) Furthermore, an acute CH-19 Sweet intake in humans has enhanced sympathetic nervous activity, thermogenesis, and energy expenditure as effectively as hot red pepper, 12,13) a chronic CH-19 Sweet intake has reduced the body fat and body weight in healthy people, 14) and a chronic capsinoid intake has enhanced the energy expenditure and fat oxidation in obese people. 15) Since CH-19 Sweet (capsinoids) has little pungency for humans, 9) it is possible that it may be more acceptable for many people than hot red pepper (capsaicin).…”