Effects of Chemically-Functionalized Single-Walled Carbon Nanotubes on the Morphology and Vitality of D54MG Human Glioblastoma Cells

Hopkins, Seantel; Gottipati, Manoj K.; Bekyarova, Elena; Haddon, Robert C.; Parpura, Vladimir

doi:10.3390/neuroglia1020022

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Hopkins et al demonstrated the application of chemically functionalized carbon nanotubes (CNTs) against GBM. In this work, tetrahydrofurfuryl-terminated polyethylene glycol (PEG-THFF) attached to the surface of CNTs not only increased the solubility of carbon-based NPs in water, but it also reduced the proliferation rate of D54MG cells (human glioblastoma cells) while increasing the rate of cell death [68].…”

Section: Therapeutic Functionalitymentioning

confidence: 99%

“…In many cases, the use of both inorganic and organic components (nanocomposites) results in effective nanostructure-based theranostic systems [65]. All of these strategies have been combined with increasing selectivity, biocompatibility, cytocompatibility, and greater permeability of the BBB for the treatment of GBM [66].…”

Section: The Use Of Nanotechnology For Brain Tumor Diagnosis and Therapymentioning

confidence: 99%

“…Nanodiagnostics, as the application of nanotechnology to medical diagnostics, promises higher sensitivity, lower costs, and more efficient diagnostic applications as well as higher intracellular imaging capabilities [67,68]. With regards to imaging of malignant brain tumors using NPs, Yan et al designed and synthesized an optical/paramagnetic nanoprobe based on a multi-labeled dendrimer.…”

Section: Diagnostic Functionalitymentioning

confidence: 99%

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Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

Mostafavi

Medina-Cruz

Vernet-Crua

et al. 2021

Expert Opinion on Drug Delivery

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Introduction: Current brain cancer treatments, based on radiotherapy and chemotherapy, are sometimes successful, but they are not free of drawbacks. Areas covered: Traditional methods for the treatment of brain tumors are discussed here with new solutions presented, among which the application of nanotechnology has demonstrated promising results over the past decade. The traditional synthesis of nanostructures, which relies on the use of physicochemical methodologies are discussed, and their associated concerns in terms of environmental and health impact due to the production of toxic by-products, need for toxic catalysts, and their lack of biocompatibility are presented. An overview of the current situation for treating brain tumors using nanotechnological-based approaches is introduced, and some of the latest advances in the application of green nanomaterials (NMs) for the effective targeting of brain tumors are presented. Expert opinion: Green nanotechnology is introduced as a potential solution to toxic NMs through the application of environmentally friendly and cost-effective protocols using living organisms and biomolecules. The current status of this field, such as those involving clinical trials, is included, and the possible limitations of green-NMs and potential ways to avoid those limitations are discussed so that the field can potentially evolve.

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Section: Therapeutic Functionalitymentioning

confidence: 99%

Section: The Use Of Nanotechnology For Brain Tumor Diagnosis and Therapymentioning

confidence: 99%

Section: Diagnostic Functionalitymentioning

confidence: 99%

See 1 more Smart Citation

Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

Mostafavi

Medina-Cruz

Vernet-Crua

et al. 2021

Expert Opinion on Drug Delivery

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“…It reduces cell proliferation along with an increase in cell death rates in human glioma cells. [ 27 ]…”

Section: N Anocarrier P Latforms For B Rain D Eliverymentioning

confidence: 99%

Targeting to Brain Tumor

Kumar

Pattnaik

Satapathy

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Cancer is a class of disorder characterized by anomalous growth of cells escalating in an uncontrolled way. Among all the cancers, treatment of cancerous brain tumors has been a tough challenge for the research scientists. Moreover, the absence of early-stage symptoms delays its diagnosis, consequently worsening its severity. Conventional treatments such as surgery, radiation, and chemotherapy are still linked with several limitations. The therapeutic effect of most of the anticancer drugs is highly restricted by their inability to pass the blood–brain barrier, low solubility, limited therapeutic window, and so on. Alarming incidences of brain cases associated with low survival rate across the globe coupled with the inefficiency of current treatment strategies have forced the formulation scientists to investigate nanotechnology-based advanced therapeutic approaches to tackle the disease. Various nanoplatforms such as polymeric nanoparticles (NPs), nanoliposomes, dendrimers, carbon nanotubes, and magnetic NPs have been reported in the past years to improve the drug administration into brain tumor cells and to minimize their off-target distribution for lesser side effects and better treatment outcomes. The review presents updated information on the nanocarrier-based drug delivery systems reported in the past few years for the treatment of brain tumor along with new advancements in this field. It also throws some light on the recent challenges faced in the practical field for the successful clinical translation of such nanodrug carriers along with a discussion on the future prospects.

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Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives

Kumar,

Ansari,

Basu

et al. 2024

Advanced Therapeutics

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Carbon nanotubes (CNTs) have emerged as revolutionary tools, offering innovative approaches to both diagnostic and therapeutic challenges spanning various cancer types. CNTs serve as imaging agents for early detection through MRI, CT, and fluorescence. They provide precise results with biosensors detecting cancer biomarkers for rapid diagnosis. In cancer therapy, CNTs excel in targeted drug delivery, enhancing bioavailability and minimizing off‐target effects. Their prowess in photothermal therapy selectively eradicates cancer cells. Despite challenges, ongoing research highlights CNT's transformative potential, promising enhanced precision, efficacy, and personalized cancer care across diverse malignancies in future clinical practice.

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Effects of Chemically-Functionalized Single-Walled Carbon Nanotubes on the Morphology and Vitality of D54MG Human Glioblastoma Cells

Cited by 5 publications

References 33 publications

Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?

Targeting to Brain Tumor

Carbon Nanotubes in Cancer Diagnosis and Treatment: Current Trends and Future Perspectives

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