Effects of Chicory Inulin on Serum Metabolites of Uric Acid, Lipids, Glucose, and Abdominal Fat Deposition in Quails Induced by Purine-Rich Diets

Abstract

Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory inulin on serum metabolites of uric acid (UA), lipids, glucose, and abdominal fat deposition in quail model induced by a purine-rich diet. In this study, 60 male French quails were randomly allocated to five groups: CON (control group), MOD (model group), BEN (benzbromarone-treated group), CHI-H (high-dosage chicory inulin-treated group), and CHI-L (low-dosage chicory inulin-treated group). The serum UA level was significantly increased in the model group from days 7 to 28, as well as triglyceride (TG) and free fatty acid (FFA) increased later in the experimental period. The abdominal fat ratio was increased on day 28. Benzbromarone can decrease UA levels on days 14 and 28. The high and low dosage of chicory inulin also decreased serum UA levels on days 7, 14, and 28. The abdominal fat ratio, activity, and protein of acetyl-CoA carboxylase (ACC) were decreased in chicory inulin-treated groups. The activities of xanthine oxidase (XOD) and fatty acid synthase (FAS) were increased in the model group and decreased in the benzbromarone and chicory inulin groups. This study evaluated a quail model of induced hyperuricemia with other metabolic disorders caused by a high-purine diet. The results indicated that a purine-rich diet might contribute to the development of hyperuricemia, hypertriglyceridemia, and abdominal obesity. Chicory inulin decreased serum UA, TG, and abdominal fat deposition in a quail model of hyperuricemia by altering the ACC protein expression and FAS and XOD activities.

Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

“…Moreover, we observed a strong hypolipidemic effect of chicory inulin in T2DM rats. These results agree with a previous study showing that chicory inulin promoted lipid metabolism by altering the expression of acetyl‐CoA carboxylase and the activities of fatty acid synthase and xanthine oxidase .…”

“…We also observed disorders of lipid metabolism in T2DM rats as evidenced by elevated serum levels of TG, TC and NEFA, which is similar to the metabolic profile in the humans with T2DM . The therapeutic effects of chicory inulin on metabolic disorders have been extensively reported . A previous study showed that oral administration of chicory inulin at 5 g/kg/day for 10 weeks protected the rats from diabetes‐induced renal injury.…”

Growth performance, carcass characteristics, meat and egg quality, and intestinal microbiota in Beijing-you chicken on diets with inclusion of fresh chicory forage

“…Lee et al (2003) suggested that the use of highly digestible feed ingredients in the diet and hygienic conditions in research studies could mask the beneficial effects of forage on growth performance and carcass traits. A series of animal studies demonstrated that chicory fructans could affect the metabolism of lipids primarily by decreasing triglyceridemia ( Van Loo 2007;Lin et al 2014). In this study, dietary supplementation of chicory forage significantly decreased abdominal fat yield compared to the control, which confirmed other reports (Yusrizal and Chen 2003;Ali 2011;Saeed et al 2017).…”

Impact of Consumption of Chicory Leaf Extract in Adjunct with Non-surgical Periodontal Therapy on Serum Antioxidant and Lipid Status in Patients with Periodontal Disease: Preliminary Study

“…Chicory regulated the expression of acetyl-CoA carboxylase, xanthine oxidase and fatty acid synthase (39). Furthermore, Chicory inhibited xanthine oxidase, and consequently, abolished uric acid synthesis; so the researchers suggested that this herb might have beneficial role against gout disease, while our current results are in contrast with Lin Z's conclusion (39).…”