Effects of Chlorpheniramine and l-histidine on vestibular compensation in goldfish, Carassius auratus

Piratello, Aline Cristina; Mattioli, Rosana

doi:10.1016/j.neulet.2004.05.105

Cited by 10 publications

(8 citation statements)

References 17 publications

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“…Betahistine or thioperamide, another potent and selective H 3 receptor antagonist, reduce acute symptoms after vestibular deafferentation in rats (Pan et al ., ) and improve recovery in cats (Tighilet et al ., 2006; 2007). Similarly, chlorpheniramine, an H 1 receptor antagonist, was also reported to accelerate vestibular compensation in hemilabyrinthectomized goldfish (Piratello and Mattioli, ). All these observations demonstrate a key position of hypothalamic histaminergic afferent inputs in vestibular functions and compensation.…”

Section: Discussionmentioning

confidence: 93%

Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats

Zhang

Zhuang

et al. 2013

British J Pharmacology

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BACKGROUND AND PURPOSEAnti-histaminergic drugs have been widely used in the clinical treatment of vestibular disorders and most studies concentrate on their presynaptic actions. The present study investigated the postsynaptic effect of histamine on medial vestibular nucleus (MVN) neurons and the underlying mechanisms. EXPERIMENTAL APPROACHHistamine-induced postsynaptic actions on MVN neurons and the corresponding receptor and ionic mechanisms were detected by whole-cell patch-clamp recordings on rat brain slices. The distribution of postsynaptic histamine H1, H2 and H4 receptors was mapped by double and single immunostaining. Furthermore, the expression of mRNAs for H1, H2 and H4 receptors and for subtypes of Na + -Ca 2+ exchangers (NCXs) and hyperpolarization-activated cyclic nucleotide-gated (HCN) channels was assessed by quantitative real-time RT-PCR. KEY RESULTSA marked postsynaptic excitatory effect, co-mediated by histamine H1 and H2 receptors, was involved in the histamine-induced depolarization of MVN neurons. Postsynaptic H1 and H2 rather than H4 receptors were co-localized in the same MVN neurons. NCXs contributed to the inward current mediated by H1 receptors, whereas HCN channels were responsible for excitation induced by activation of H2 receptors. Moreover, NCX1 and NCX3 rather than NCX2, and HCN1 rather than HCN2-4 mRNAs, were abundantly expressed in MVN. CONCLUSION AND IMPLICATIONSNCXs coupled to H1 receptors and HCN channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on MVN neurons. These results highlight an active role of postsynaptic mechanisms in the modulation by central histaminergic systems of vestibular functions and suggest potential targets for clinical treatment of vestibular disorders.

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Section: Discussionmentioning

confidence: 93%

Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats

Zhang

Zhuang

et al. 2013

British J Pharmacology

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“…Some studies indicate that the CHS has an important role in the synaptic plasticity and CNS functional recovery, but these data are controversial. Piratello and Mattioli (14,15) showed that the CPA accelerated the functional recovery process in fish after a vestibular system lesion, while Weiler et al (12) found that a central injection of histidine accelerated recovery in mice after unilateral lesion in the TMN region. The blockade of histamine H 1 receptors may play a role in spatial cognition, impairing the acquisition of memory in rats evaluated in an 8-arm radial maze (25).…”

Section: Discussionmentioning

confidence: 99%

“…This dose have been shown to be effective for fish in several models of learning and memory in our laboratory (11,14,15). The saline solution was used as experimental control.…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

“…The CHS seems also to be involved in neural plasticity and functional recovery following damage to the CNS. Piratello and Mattioli (14) suggest that the inhibition of the histaminergic system by chlorpheniramine accelerated the functional recovery process observed after hemilabyrinthectomy in goldfish but that the administration of L-histidine did not cause any effects compared to saline-treated animals. In another study, it was shown that the body tilt of animals treated with thioperamide decreased from the 13th day on, while the animals treated with saline presented a significant reduction on the 7th day of treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Much research has been done to investigate the influences of the central histaminergic system (CHS) on CNS functions. Among them are circadian rhythm (2), anxiety (3)(4)(5), pain perception (6), locomotor activity modulation (7), learning and memory processes (8)(9)(10)(11), synaptic plasticity, and CNS functional recovery (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Garção

Canto-de-Souza

Romaguera

et al. 2009

Braz J Med Biol Res

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We determined the effect of an H 1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find the food (latency) was analyzed separately at T1 and T8 by the Kruskal-Wallis test, followed by the Student Newman-Keuls test. At T1 the latencies (mean ± SEM) of the A-SAL (586.3 ± 13.6) and A-CPA (600 ± 0) groups were significantly longer than those of the S-SAL (226.14 ± 61.15) and S-CPA (356.33 ± 68.8) groups. At T8, the latencies of the A-CPA group (510.11 ± 62.2) remained higher than those of the other groups, all of which showed significantly shorter latencies (A-SAL = 301.91 ± 78.32; S-CPA = 191.58 ± 73.03; S-SAL = 90.28 ± 41) compared with T1. These results support evidence that training can lead to functional recovery of spatial-choice learning in telencephalonless fish and also that the antagonist of the H 1 receptor impairs it.

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Chlorpheniramine

Minigh¹

2008

xPharm: The Comprehensive Pharmacology Reference

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Effects of Chlorpheniramine and l-histidine on vestibular compensation in goldfish, Carassius auratus

Cited by 10 publications

References 17 publications

Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats

Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats

Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation

Chlorpheniramine

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