Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns

Rousseau, Anne-Françoise; Foidart-Desalle, Marguerite; Ledoux, Didier; Remy, Céline; Croisier, Jean-Louis; Damas, Pierre; Cavalier, Étienne

doi:10.1016/j.burns.2014.07.005

Cited by 46 publications

(29 citation statements)

References 39 publications

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“…Most studies are focused on burn children and, to the best of our knowledge, only two papers reported interventional results in adults: one during acute care [14] and one during sequelar phase [15]. Even if a lot of questions remain unsolved regarding burn related hypovitaminosis D, there is a solid rationale to supplement burn patients with vitamin D as soon as acute phase [1].…”

Section: Introductionmentioning

confidence: 97%

Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects

Rousseau

Damas

Ledoux

et al. 2015

Burns

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Section: Introductionmentioning

confidence: 97%

Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects

Rousseau

Damas

Ledoux

et al. 2015

Burns

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“…Vitamin D supplementation in an aging population may be important for the preservation of physical function and the reduction in risk of falls [73] . In a clinical trial on burn patients, vitamin D and calcium supplementation increased quadriceps strength [74] . In the same sense, vitamin D supplementation significantly increased muscle strength [75] , and a recent randomized controlled trial demonstrated that supplementation with vitamin D over 4 months in older women with low vitamin D levels resulted in a 10% increase in muscle fiber size [76] .…”

Section: Vitamin Dmentioning

confidence: 99%

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

Campins

Camps²,

Riera³

et al. 2016

Pharmacology

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Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can include genetic influence, immobility or disuse, endocrine factors, inflammation and nutritional deficiencies. These disorders involve an imbalance between anabolic and catabolic pathways that rules muscle mass. Many drugs taken regularly for common conditions may interact with some mechanisms that can alter the balance between protein synthesis and degradation. This may lead to a harmful or a beneficial effect on muscle mass and strength. Widely prescribed drugs could play an important role during the time of onset and development of sarcopenia. In this paper, we reviewed the current understanding of how can drugs contribute positively or negatively on sarcopenia and muscle wasting. We decided to focus this review on oral common drugs, which are usually prescribed in older adults, leaving aside other drugs as hormone therapy.

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“…However, there was no significant change in bone health in either of the groups. Quadriceps strength did improve in the case group ( 19 ). Table 5 shows the results of some previous studies.…”

Section: Discussionmentioning

confidence: 87%

Serum 25-Hydroxyvitamin D Levels in Pediatric Burn Patients

et al. 2016

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BackgroundPrevious studies have implicated the important and active role of vitamin D in the immune system.ObjectivesThe aim of this study was to evaluate serum levels of 25-hydroxyvitamin D in children with burn injuries.Materials and MethodsIn this cross-sectional study, 118 patients with various degrees of burn injuries were enrolled. A checklist consisting of demographic data, total body surface area (TBSA) affected by burn, degree of burn, serum level of 25(OH)D, total protein, albumin, electrolytes, and parathyroid hormone was recorded for each patient.ResultsSixty-eight (57.6%) males and 50 (42.4%) females with a mean age of 4.04 years (SD = 3.04) were evaluated. The mean level of 25(OH)D was 14.58 ng/mL (SD = 6.94). Levels of 25(OH)D in four (3.39%) cases were higher than 30 ng/mL, while 95 (81.35%) cases had levels lower than 20 ng/mL, and 19 (16.10%) cases had levels of 21 - 30 ng/mL. The level of 25(OH)D was below recommended levels in 96.61% of cases, while 81.34% had vitamin D deficiency and 16.1% had insufficiency. We found a significant correlation between vitamin 25(OH)D and total protein, albumin, and total and ionized calcium (P < 0.001). There was also a significant negative correlation between 25(OH)D and TBSA affected by burn (P = 0.001).ConclusionsThe levels of 25(OH)D in children suffering from severe burns were low. Supplementation might be useful in patients with very low levels of serum vitamin D.

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Effects of cholecalciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: A one-year pilot randomized controlled trial in adults with severe burns

Cited by 46 publications

References 39 publications

Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects

Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

Serum 25-Hydroxyvitamin D Levels in Pediatric Burn Patients

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