Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

Abstract

ObjectiveThis experiment was conducted to investigate the effects of chromium picolinate (CrP) on fat deposition, genetic expression and enzymatic activity of lipid metabolism-related enzymes.MethodsTwo hundred forty one-day-old Ross broilers were randomly divided into 5 groups with 4 replicates per group and 12 Ross broiler chicks per replicate. The normal control group was fed a basal diet, and the other groups fed the same basal diet supplemented with 0.1, 0.2, 0.4, and 0.8 mg/kg CrP respectively. The experiment lasted for 21 days.ResultsAdded CrP in the basal diet decreased the abdominal fat, had no effects on subcutaneous fat thickness and inter-muscular fat width; 0.2 mg/kg CrP significantly decreased the fatty acid synthase (FAS) enzymatic (p<0.05); acetyl-CoA carboxylase (ACC) enzymatic activity decreased in all CrP groups (p<0.05); hormone-sensitive lipase (HSL) enzymatic activity also decreased, but the change was not significant (p>0.05); 0.4 mg/kg CrP group significantly decreased the lipoprotein lipase (LPL) enzymatic activity. FAS mRNA expression increased in all experimental groups, and the LPL mRNA expression significantly increased in all experimental groups (p<0.05), but not 0.2 mg/kg CrP group.ConclusionThe results indicated that adding CrP in basal diet decreased the abdominal fat percentage, had no effects on subcutaneous fat thickness and inter-muscular fat width, decreased the enzymatic activity of FAS, ACC, LPL and HSL and increased the genetic expression levels of FAS and LPL.

Effects of organic chromium sources on growth performance, lipid metabolism, antioxidant status, breast amino acid and fatty acid profiles in broilers

“…It has been reported that Cr could enhance glucose transporter‐4 translocation and insulin‐stimulated glucose transport, which might be induced by decreasing circulating membrane cholesterol levels and thereby positively affecting membrane fluidity 37,38 . In addition, Cr reportedly regulated lipid metabolism by decreasing the enzymatic activity of fatty acid synthase and hormone‐sensitive lipase 15 . Zheng et al 31 .…”

“…Cr is involved in the metabolism of insulin by stimulating glucose consumption and increasing mRNA expression of the insulin receptor and glucose transporter‐4 12–14 . Cr may regulate lipid metabolism by decreasing the enzymatic activity of the fatty acid synthase or hormone‐sensitive lipase 15 . In addition, Cr is also vital for chromodulin to stimulate the activity of the insulin receptor protein tyrosine kinase, which is required for stabilizing proteins and nucleic acid formation 16,17 .…”

Effects of lycopene on abdominal fat deposition, serum lipids levels and hepatic lipid metabolism-related enzymes in broiler chickens

“…However, excessive deposition of abdominal and subcutaneous fat resulted from the intensive production, not only leads to high occurance of ascites syndrome and sudden death syndrome, but also has a negative impact on consumers' healthy diet [1]. Studies have shown that dietary supplementation of specific natural or synthetic compounds had lipid lowering effect [2][3][4]. Consumers increasingly prefer natural to synthetic compounds in consideration of food safety and health.…”

Effects of different chromium sources on growth performance, serum biochemical, hepatopancreas glycometabolism enzymes activities, IR, GLUT2 and SGLT1 gene expression of common carp ( Cyprinus carpio )

“…Trivalent chromium (Cr 3+ ) is an essential trace element that plays an important role in carbohydrate, lipid, protein and nucleic acid metabolism (Chen et al, 2017). The magnitude of the metabolic response of Cr 3+ apparently depends on the amount and chemical form (inorganic compounds and organic complexes) of supplemental Cr.…”