Effects of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers in Patients with Type 2 Diabetes Mellitus: a Randomized Clinical Trial

Abstract

Type 2 diabetes mellitus (T2DM) is a serious public health problem accompanies with several complications. This study was conducted to evaluate the effects of chromium picolinate (CrPic) supplementation on the glycemic status and lipid profile in patients with T2DM. The patients with T2DM (n = 52) were randomly allocated into 2 groups. One group received 400 µg CrPic per day and the other group took placebo; the intervention duration was 8 weeks. Anthropometric indices and metabolic factors were measured at the beginning, and at end of the study. The patients were recommended not to change their normal diet, life style and medication. No significant changes were observed for weight, body mass index, and fasting blood glucose (FBG) in both groups; while intra-groups changes in homeostatic model assessment for insulin resistance (HOMA-IR) value was significant (p < 0.05). Results of analysis of covariance showed that there were significance differences between groups in total cholesterol, low density lipoprotein cholesterol and HOMA-IR at the end of the intervention adjusting for baseline levels (p = 0.035, 0.030 and < 0.001, respectively). In this study, oral supplementation with 400 µg CrPic for eight weeks did not alter FBG concentration as well as anthropometric parameters in individuals with T2DM. However, the modest beneficial effects of chromium supplementation on insulin resistance as indicated by HOMA-IR and lipid profile were found.

Vitamin D deficiency in early life regulates gut microbiome composition and leads to impaired glucose tolerance in adult and offspring rats

“…80 Chromium 2-picolinate is one of the functional ingredients in health foods, which can reduce the glucose level and insulin resistance of diabetics. 81 These collectively support that vitamin D deficiency could affect the tryptophan metabolic pathway by gut microbiota, which could lead to impaired glucose tolerance. There was a sex difference in the effect of vitamin D deficiency on the beta diversity of gut microbiota, which was greater in males than in females.…”

Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions

“…No prior research has shown that all therapies significantly reduced insulin and HOMA-IR levels in T2DM models when given individually but substantially less when administered with PGZ + Cr-GTF compared to PL and PGZ. [ 21 ] PGZ with both Cr compounds improved FBG and HbA1c levels but did not improve pharmacological responsiveness.…”

Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats

“…Thus, CP has been widely used in the fields of hypoglycemic functional foods and pharmaceuticals. In addition, CP has been confirmed to have a positive effect on diabetic complications, such as protecting diabetic atherosclerosis by inhibiting the expression of Thrombospondin-1, improving diabetic nephropathy and coronary heart disease through antioxidant and anti-inflammation effects [ 21 , 27 , 28 , 29 ]. Here we administered CP to diabetic rats for 8 weeks.…”