Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Asbaghi, Omid; Naeini, Fatemeh; Mahnaz, Rezaei Kelishadi; Ghaedi, Ehsan; Eslampour, Elham; Nazarian, Behzad; Ashtary‐Larky, Damoon; Amirmansour, Alavi Naeini

doi:10.1016/j.phrs.2020.105098

Cited by 41 publications

(29 citation statements)

References 53 publications

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“…To measure the risk of bias for each included study, we used Cochrane collaboration’s tool [ 27 ], which contained seven domains: allocation concealment, performance bias, random sequence generation, reporting bias, and detection, attrition bias, and other sources of bias. The quality assessment procedure was described in our earlier studies [ 8 , 28 ]. Moreover, two independent investigators (OA and DAL) performed the risk of bias assessment.…”

Section: Methodsmentioning

confidence: 99%

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Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Background: There is a growing interest in the considerable benefits of dietary supplementations, such as folic acid, on the glycemic profile. We aimed to investigate the effects of folic acid supplementation on glycemic control markers in adults. Methods: Randomized controlled trials examining the effects of folic acid supplementation on glycemic control markers published up to March 2021 were detected by searching online databases, including Scopus, PubMed, Embase, and ISI web of science, using a combination of related keywords. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention and control groups at follow-up. Meta-regression and non-linear dose-response analysis were conducted to evaluate the association between pooled effect size and folic acid dosage (mg/day) and duration of the intervention (week). From 1814 detected studies, twenty-four studies reported fasting blood glucose (FBG), fasting insulin, hemoglobin A1C (HbA1C), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as an outcome measure. Results: Results revealed significant reductions in FBG (weighted mean difference (WMD): −2.17 mg/dL, 95% CI: −3.69, −0.65, p = 0.005), fasting insulin (WMD: −1.63 pmol/L, 95% CI: −2.53, −0.73, p < 0.001), and HOMA-IR (WMD: −0.40, 95% CI: −0.70, −0.09, p = 0.011) following folic acid supplementation. No significant effect was detected for HbA1C (WMD: −0.27%, 95% CI: −0.73, 0.18, p = 0.246). The dose-response analysis showed that folic acid supplementation significantly changed HOMA-IR (r = −1.30, p-nonlinearity = 0.045) in non-linear fashion. However, meta-regression analysis did not indicate a linear relationship between dose, duration, and absolute changes in FBG, HOMA-IR, and fasting insulin concentrations. Conclusions: Folic acid supplementation significantly reduces some markers of glycemic control in adults. These reductions were small, which may limit clinical applications for adults with type II diabetes. Further research is necessary to confirm our findings.

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Section: Methodsmentioning

confidence: 99%

“…It has been assumed that dietary supplements have led to promising outcomes for T2DM treatment [ 7 , 8 , 9 , 10 ]. Namely, folic acid is known as one of the members of the vitamin B complex, which is crucial for red blood cell (RBC) increment and other body cells as an essential vitamin.…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

et al. 2021

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“…Diese Effekte waren basierend auf einer Subgruppenanalyse bei einer längerfristigen Supplementation von mindestens 12 Wochen stärker ausgeprägt, zeigten jedoch keine Abhängigkeit von der verwendeten Chrom-Dosierung. Alle inkludierten Studien wurden in ihrer Qualität als gut bewertet, jedoch wurde in der Metaanalyse keine Stratifizierung der Ergebnisse nach der verwendeten Chrom-Formulierung vorgenommen (Chrompicolinat, Chromchlorid, Chrom aus Bierhefe) [356]. Basierend auf 2 vorangegangenen systematischen Reviews und Metaanalysen (22 RCTs, n = 1332 T2Dm und 14 RCTs, n = 875 T2DM) waren die Effekte einer Chrom-Supplementation im Vergleich zu Placebo auf die Nüchternblutglukosekonzentration bei Verwendung von Chrompicolinat am stärksten ausgeprägt bzw.…”

Section: Ddg-praxisempfehlungunclassified

Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

Skurk

Bosy‐Westphal

Grünerbel³

et al. 2021

Diabetologie und Stoffwechsel

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“…The results of a recent meta‐analysis conducted by Asbaghi et al 93 demonstrated that chromium supplementation significantly reduced all glycaemic control indices such as insulin, fasting plasma glucose (FPG), Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR), and haemoglobin A1C (HbA1C) levels in patients with T2DM. In addition, the long‐term intervention (≥12 weeks) contributed to a greater reduction of all mentioned parameters.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review

Kooshki

Tutunchi

Vajdi

et al. 2021

Clin Exp Pharma Physio

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Diabetes mellitus is a metabolic disorder defined as an increase in blood glucose levels (hyperglycaemia) and insufficient production or action of insulin produced by the pancreas. Chronic hyperglycaemia leads to increased reactive oxygen species (ROS) production and oxidative stress, which consequently results in insulin resistance, beta cell degeneration, dyslipidaemia, and glucose intolerance in diabetic patients. Chromium has an essential role in the metabolism of proteins, lipids, and carbohydrates through increasing insulin efficiency. This systematic review aimed to evaluate chromium supplementation's potential roles in oxidative stress indices in diabetes mellitus. A systematic search was performed in PubMed, Scopus, Google Scholar, Cochrane, and Science Direct databases until November 2020. All clinical trials and animal studies that assessed chromium's effect on oxidative stress indices in diabetes mellitus and were published in English‐language journals were included. Finally, only 33 out of 633 articles met the required criteria for further analysis. Among 33 papers, 25 studies were performed on animals, and eight investigations were conducted on humans. Twenty‐eight studies of chromium supplementation lead to reducing oxidative stress indices. Also, 23 studies showed that chromium supplementation markedly increased antioxidant enzymes' activity and improved levels of antioxidant indices. In conclusion, chromium supplementation decreased oxidative stress in diabetes mellitus. However, further clinical trials are suggested in a bid to determine the exact mechanisms.

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Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Cited by 41 publications

References 53 publications

Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus

A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review

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