Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward-related brain areas in rats

Wang, Dequan; Wang, Xinling; Wang, Chong-Yang; Wang, Yuan; Li, Suxia; Liu, Ke-Zhi

doi:10.1016/j.bbr.2019.01.035

Cited by 24 publications

(22 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Per2 peaks at ZT8. 30,31 In the hippocampus, while the same circadian gene expression profile is seen as in the SCN, there is a phase-shift of about 6-10 hours. 30 In this region, Bmal1 peaks at ZT0-4 and Per2 at ZT18.…”

Section: Microglia Are Important For Diurnal Activity Profilesmentioning

confidence: 99%

“…However, in general, Bmal1 is reportedly highest in the SCN at ZT18 30 to ZT0. 31 Per1 reaches a peak at ZT16 and remains high until ZT0. 31 Per2 peaks at ZT8.…”

Section: Microglia Are Important For Diurnal Activity Profilesmentioning

confidence: 99%

“…31 Per1 reaches a peak at ZT16 and remains high until ZT0. 31 Per2 peaks at ZT8. 30,31 In the hippocampus, while the same circadian gene expression profile is seen as in the SCN, there is a phase-shift of about 6-10 hours.…”

Section: Microglia Are Important For Diurnal Activity Profilesmentioning

confidence: 99%

See 2 more Smart Citations

Microglial ablation in rats disrupts the circadian system

et al. 2020

View full text Add to dashboard Cite

Research is increasingly revealing new roles for microglia in the developed brain beyond their well-known function in protecting it from pathogens and injury. 1,2 For example, recent work has demonstrated microglia are likely to be important for memory processing and executive function. [3][4][5][6] Microglial activity directed at pruning of synapses mediates memory degradation in a complement-dependent manner in a contextual fear conditioning task. 3 Likewise, spatial learning is impaired in animals that are unable to reduce their CA1 microglial density during task acquisition 7 and recognition memory is improved when microglia repopulate the brain after depletion. 8 Roles for microglia have also emerged for regulation of feeding and satiety, 9 and in modifying pain responses. 10,11

show abstract

Section: Microglia Are Important For Diurnal Activity Profilesmentioning

confidence: 99%

“…However, in general, Bmal1 is reportedly highest in the SCN at ZT18 30 to ZT0. 31 Per1 reaches a peak at ZT16 and remains high until ZT0. 31 Per2 peaks at ZT8.…”

Section: Microglia Are Important For Diurnal Activity Profilesmentioning

confidence: 99%

See 1 more Smart Citation

Microglial ablation in rats disrupts the circadian system

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several studies report diurnal variation of core circadian clock gene and protein expression in the VTA ( Baird et al, 2013 ; Chung et al, 2014 ; Wang et al, 2019 ). This is further supported by ex vivo bioluminescent recordings of PERIOD2::LUCIFERASE rhythms in the VTA of PER2:LUC reporter mice ( Landgraf et al, 2014 ; Logan et al, 2015 ; Landgraf et al, 2016a ), a knock-in mouse line expressing the firefly luciferase gene fused to the Period2 gene that allows for real-time visual monitoring of self-sustained circadian oscillations ( Yoo et al, 2004 )).…”

Section: The Ventral Tegmental Area As a Circadian Oscillatormentioning

confidence: 99%

The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders

2022

View full text Add to dashboard Cite

Circadian rhythms convergently evolved to allow for optimal synchronization of individuals’ physiological and behavioral processes with the Earth’s 24-h periodic cycling of environmental light and temperature. Whereas the suprachiasmatic nucleus (SCN) is considered the primary pacemaker of the mammalian circadian system, many extra-SCN oscillatory brain regions have been identified to not only exhibit sustainable rhythms in circadian molecular clock function, but also rhythms in overall region activity/function and mediated behaviors. In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA’s and NAc’s inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to develop substance use disorders (SUDs).

show abstract

“…Disturbed clock gene expression in reward‐related brain regions such as the VTA after chronic cocaine application suggests a role of the VTA clock in the regulation of reward pathways . In Per2 clock gene mutant mice, altered monoamine oxidase ( Maoa ) mRNA expression levels as well as reduced MAOA is accompanied by elevated dopamine levels in the NAc .…”

Section: Functional Studies Of Extra‐scn Oscillatorsmentioning

confidence: 99%

Regulation and function of extra‐SCN circadian oscillators in the brain

2020

View full text Add to dashboard Cite

Most organisms evolved endogenous, so called circadian clocks as internal timekeeping mechanisms allowing them to adapt to recurring changes in environmental demands brought about by 24-hour rhythms such as the light-dark cycle, temperature variations or changes in humidity. The mammalian circadian clock system is based on cellular oscillators found in all tissues of the body that are organized in a hierarchical fashion. A master pacemaker located in the suprachiasmatic nucleus (SCN) synchronizes peripheral tissue clocks and extra-SCN oscillators in the brain with each other and with external time. Different time cues (so called Zeitgebers) such as light, food intake, activity and hormonal signals reset the clock system through the SCN or by direct action at the tissue clock level. While most studies on non-SCN clocks so far have focused on peripheral tissues, several extra-SCN central oscillators were characterized in terms of circadian rhythm regulation and output. Some of them are directly innervated by the SCN pacemaker, while others receive indirect input from the SCN via other neural circuits or extra-brain structures. The specific physiological function of these non-SCN brain oscillators as well as their role in the regulation of the circadian clock network remains understudied. In this review we summarize our current knowledge about the regulation and function of extra-SCN circadian oscillators in different brain regions and devise experimental approaches enabling us to unravel the organization of the circadian clock network in the central nervous system. K E Y W O R D S brain, circadian clock, clock gene, CNS, entrainment 2 of 14 | BEGEMANN Et Al.major depression or cardiovascular disorders are promoted by chronodisruption, that is, the perturbation of internal clock function or of the alignment of these clocks with external time. 4 Besides shift work, other chronodisruptive factors are sleep curtailment, high-energy diets or mistimed eating patterns, and nocturnal light pollution. 5,6 Resetting stimuli (eg light)Resetting stimuli (eg PUFAs) Resetting stimuli (eg NO/CO) RORE D-box E-box CLOCK BMAL1 REV-ERBs RORs DBP NFIL3 PERs CRYs CCGsHow to cite this article: Begemann K, Neumann A-M, Oster H. Regulation and function of extra-SCN circadian oscillators in the brain. Acta Physiol.

show abstract

Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward-related brain areas in rats

Cited by 24 publications

References 62 publications

Microglial ablation in rats disrupts the circadian system

Microglial ablation in rats disrupts the circadian system

The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders

Regulation and function of extra‐SCN circadian oscillators in the brain

Contact Info

Product

Resources

About