Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney

Das, Subir Kumar; Varadhan, Sowmya; Dhanya, L.; Mukherjee, Sukhes; Vasudevan, DM

doi:10.1007/s12291-008-0075-6

Cited by 33 publications

(22 citation statements)

References 19 publications

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“…One main function of GST is to catalyze the biotransformation of xenobiotics, leading to detoxification (Hayes & Pulford, 1995). The marked reduction in the activity of SOD in rats administered 45 % ethanol and the enhanced SOD activities when A.M. was co-administered were also in agreement with other studies (Das et al, 2008;Adaramoye et al, 2009). SOD catalyzes the clearance of superoxide anion radicals, preventing the formation of H 2 O 2 .…”

Section: Discussionsupporting

confidence: 85%

Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats.

Nwozo¹,

Oyinloye²

2011

Acta Biochim Pol

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In recent years there have been remarkable developments in the prevention of diseases, especially with regards to the role of free radicals and antioxidants. Ethanol-induced oxidative stress appears to be one mechanism by which ethanol causes liver injury. The protective effect of aqueous plant extract of Aframomum melegueta on ethanol-induced toxicity was investigated in male Wistar rats. The rats were treated with 45 % ethanol (4.8 g/kg b.w.t.) for 16 days to induce alcoholic diseases in the liver. The activities of alanine aminotransferase, aspartate aminotransferase and triglyceride were monitored and the histological changes in liver examined in order to evaluate the protective effects of the plant extract. Hepatic malondialdehyde and reduced glutathione, as well as superoxide dismutase and glutathione-S-transferase activities were determined for the antioxidant status. Chronic ethanol administration resulted in a statistically significant elevation of serum alanine aminotransferases and triglyceride levels, as well as a decrease in reduced glutathione and superoxide dismutase which was dramatically attenuated by the co-administration of the plant extract. Histological changes were related to these indices. Co-administration of the plant extract suppressed the elevation of lipid peroxidation, restored the reduced glutathion, and enhanced the superoxide dismutase activity. These results highlight the ability of Aframomum melegueta to ameliorate oxidative damage in the liver and the observed effects are associated with its antioxidant activities.

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Section: Discussionsupporting

confidence: 85%

Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats.

Nwozo¹,

Oyinloye²

2011

Acta Biochim Pol

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“…In fact, ketamine is the anaesthetic drug of choice to be used in surgery of patients with some risk of kidney disease, as it does not promote any harmful effects in the kidneys [103]. In the case of ethanol, studies report that its chronic use can significantly increase urea and creatinine serum levels, as was observed by Das et al, [104] in rats exposed to ethanol (1.6 g/kg/BW/day) for 12 w.…”

Section: Discussionmentioning

confidence: 99%

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

Mendes

Simon

Hueza

2017

Int J Pharm Pharm Sci

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Objective: Studies have shown that ketamine (K) and ethanol (E) have immunomodulatory activity; however, few studies were performed with concomitant treatments. Thus, we evaluated the toxic and immunotoxic effects of this association.Methods: Wistar rats were distributed into four groups (n=8/group), each receiving one of the following treatments, for 28 d: K group (15 mg/kg of ketamine, intraperitoneally); E group [1.0 ml of ethanol 10% (approximately 0,08g/rat), gavage]; KE group, receiving both treatments; and Control (Co) group, receiving only vehicles. On day 29, animals were euthanized for biochemical, hematological, histopathological and immunological evaluation. Results:Although the experimental conditions did not elicit changes on immune parameters, some biochemical alterations were detected in the different groups. Even in the absence of nutritional and histopathological changes, or renal and hepatic markers that could indicate tissue damage, a reduction on alkaline phosphatase levels in rats from K and KE groups was observed. Moreover, changes in lipid markers [cholesterol, triglycerides and high-density lipoproteins (HDL)] were found in the different groups studied, suggesting that K and E could promote a synergic/antagonistic effect. Conclusion:In conclusion, despite biochemical alterations promoted by K and E, associated or not, the doses here employed did not promote immunotoxic effects on rats treated for 28 d. (response to the suggestion in the end of the paper).

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“…Ethanol induced lipid peroxidation of cellular membranes plays a crucial role in hepatotoxic and nephrotoxic action of ethanol [23,24]. Alcohol metabolism also tends to cause derangement in metabolism of carbohydrates, protein and lipids, while at the same time affecting cellular signaling [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Effects of Maalox Plus® Antacid and PureCal® Calcium Supplement on Physical Characteristics, Body Weight, Tissue Minerals and Histopathology of Rats Subjected to Alcohol Intoxication

To¹,

Dn²,

Ngugi³

et al. 2017

Clin Exp Pharmacol

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Overconsumption of alcohol is associated with morbidity including depletion of the body's stores of magnesium and calcium. Conversely therapy with magnesium (Mg) and calcium (Ca) in the event of chronic alcoholism normalizes elevated enzyme activities. Similar information on acute alcohol intoxication is missing. This study examined the effects of Maalox plus ® antacid and pureCal ® calcium supplement which are rich in Mg and Ca, respectively, on the body weight, tissue magnesium and calcium together with histopathology of rats exposed to acute alcohol intoxication. Alcohol was administered orally at a dosage 5 g/kg body weight for five days and supplements for two days of the week for duration of 28 days. The animals were weighed weekly and tissues obtained at the end of the treatment regimen. Statistical comparison was done using one way ANOVA followed by Tukey's test. Alcohol ingestion leads to hypomagnesemia a condition that was reversed by both drugs. Liver histology showed that alcohol caused cellular infiltration and cytoplasmic vacuolization. For kidney there was cellular infiltration and widening of tubules. Visible improvement of the liver histology architecture was discernible in rats cotreated with Ca and Mg. These results showed that alcohol altered tissue architecture and the renal cation exchange mechanism as shown by the variation in serum Ca 2 and K levels. Maalox plus ® and pureCal ® alleviated the alcohol induced adverse effects. These findings allude to these drugs being useful agents with potential applications in the management of adverse effects associated with acute alcohol intoxication.

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Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney

Cited by 33 publications

References 19 publications

Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats.

Hepatoprotective effect of aqueous extract of Aframomum melegueta on ethanol-induced toxicity in rats.

Toxic and Immunotoxic Evaluation of Ketamine and/or Ethanol in Rats During 28 Days

Effects of Maalox Plus® Antacid and PureCal® Calcium Supplement on Physical Characteristics, Body Weight, Tissue Minerals and Histopathology of Rats Subjected to Alcohol Intoxication

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