Effects of chronic methamphetamine abuse on the retinal nerve fiber layer, ganglion cell layer and Bruch’s membrane opening minimum rim width

Talebnejad, Mohammad Reza; Khazaei, Peyman; Jahanbani-Ardakani, Hamidreza; Saberikia, Zahra; Sarani, Ebrahim Moghimi; Khalili, Mohammad Reza

doi:10.1016/j.neuro.2020.07.005

Cited by 8 publications

(13 citation statements)

References 21 publications

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“…Concerning the effects of long-term Meth and Crystal Meth abuse on RNFL thickness, the results of the present study showed a signi cant reduction in the thickness of RNFL, that this decrease was greater with increasing the duration of drug addiction. The result of this study is consistent with the ndings of a study by Talebnejad et al [12]. As they have noted, RNFL thickness showed a signi cant reduction in Meth abusers compared to the healthy group [12].…”

Section: Discussionsupporting

confidence: 93%

“…The result of this study is consistent with the ndings of a study by Talebnejad et al [12]. As they have noted, RNFL thickness showed a signi cant reduction in Meth abusers compared to the healthy group [12]. Gemelli et al also reported that the average RNFL thickness in the cocaine users was signi cantly thinner compared to that of healthy subjects [24].…”

Section: Discussionsupporting

confidence: 92%

“…Talebnejad et al demonstrated thinner RNFL thickness in temporal, superior temporal, and inferior nasal areas in Meth users compared to healthy subjects [12], while Gemelli et al observed an RNFL thinning due to cocaine consumption in the superior, inferior, and nasal quadrants [24]. On the other hand, our results showed RNFL thinning in the superior and temporal quadrants.…”

Section: Discussioncontrasting

confidence: 60%

“…Ocular complications associated with Meth and Crystal Meth abuse include retinal vasculitis, endophthalmitis, episcleritis, panophthalmitis, scleritis, corneal ulceration, retinopathy, and transient visual losses [10,11]. The majority of reports on Meth-induced retinal complications are animal experimental studies or rare case reports [10,12]. Therefore, the in vivo assessment of retinal characteristics in humans with long-term Meth and Crystal Meth abuses is important for clinical purposes.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, there have been few reports on the impact of Meth and Crystal Meth on retinal nerve ber layer (RNFL) characteristics, macular thickness, and optic nerve head (ONH) features. Only in a recent study, Talebnejad et al evaluated RNFL thickness without investigation of the fovea, perifovea and parafovea features in Meth abusers and found an adverse association with RNFL thickness using optical coherence tomography (OCT) modality [12]. OCT is an imaging technique that enables non-contact direct observation and high-resolution cross-sectional images of the retinal tissue and ONH in a noninvasive manner.…”

Section: Introductionmentioning

confidence: 99%

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Macula and Optic Disc Characteristics in Methamphetamine and Crystal Methamphetamine Abusers Using Optical Coherence Tomography

Mahjoob

Maleki

Askarizadeh

et al. 2021

Preprint

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Purpose Methamphetamine and Crystal Methamphetamine abusers were compared with healthy subjects using optical coherence tomography to assess their retinal nerve fiber layer, macula, and optic disc characteristics. Methods Forty-one Methamphetamine and Crystal Methamphetamine abusers and 42 healthy subjects (mean ± SD of age: 35.82 ± 8.6 and 37.67 ± 9.1 years, respectively) were incorporated in this cross sectional study. The drug abusers had a history of at least five years of substance use through smoking. Fourier-domain optical coherence tomography was used to image and assess the characteristics of retinal nerve fiber layer, macular thickness, and optic disc in the study groups. Results The retinal nerve fiber layer thickness was significantly lower in the superior and temporal retinal quadrants of drug abusers than healthy subjects (P = 0.008 and P = 0.028, respectively). This study did not find a significant difference between drug abusers and healthy controls regarding optic to disc ratio, rim area, and disc area (P > 0.05). The comparison between the study groups showed that the reductions in perifovea and the superior quadrant of parafoveal thickness were statistically significant (P < 0.001 and P = 0.029, respectively). Conclusion Fourier-domain optical coherence tomography measurements showed that the retinal nerve fiber layer and macular thickness were different between Methamphetamine and Crystal Methamphetamine abusers and healthy subjects, which should be considered in clinical practice. It seems that these drug abuses can cause alterations in retinal morphology.

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Section: Discussionsupporting

confidence: 93%