Effects of chronic nicotine exposure on Δ9-tetrahydrocannabinol-induced locomotor activity and neural activation in male and female adolescent and adult rats

Miladinovic, Tanya; Manwell, Laurie A.; Raaphorst, Elana; Małecki, S; Rana, Shadna A.; Mallet, Paul E.

doi:10.1016/j.pbb.2020.172931

Cited by 5 publications

(2 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, recent study showed that exposure to marijuana significantly improves the motor and synaptic plasticity in animal models of Parkinson's disease 62 . Similarly, chronic nicotine pre‐exposure may modulate THC‐induced sensorimotor abnormalities, depending on age and sex 63 …”

Section: Discussionmentioning

confidence: 99%

Functional correlates of neurological soft signs in heavy cannabis users

et al. 2023

View full text Add to dashboard Cite

Sensorimotor dysfunction has been previously reported in persons with cannabis dependence. Such individuals can exhibit increased levels of neurological soft signs (NSS), particularly involving motor coordination, sensorimotor integration and complex motor task performance. Abnormal NSS levels can also be detected in non‐dependent individuals with heavy cannabis use (HCU), yet very little is known about the functional correlates underlying such deficits. Here, we used resting‐state functional magnetic resonance imaging (MRI) to investigate associations between NSS and intrinsic neural activity (INA) in HCU (n = 21) and controls (n = 26). Compared with controls, individuals with HCU showed significantly higher NSS across all investigated subdomains. Three of these subdomains, that is, motor coordination, sensorimotor integration and complex motor task behaviour, were associated with specific use‐dependent variables, particularly age of onset of cannabis use and current cannabis use. Between‐group comparisons of INA revealed lower regional homogeneity (ReHo) in left precentral gyrus, left inferior occipital gyrus, right triangular pat of the inferior frontal gyrus and right precentral gyrus in HCU compared with controls. In addition, HCU showed also higher ReHo in right cerebellum and left postcentral gyrus compared with controls. Complex motor task behaviour in HCU was significantly related to INA in postcentral, inferior frontal and occipital cortices. Our findings indicate abnormal ReHo in HCU in regions associated with sensorimotor, executive control and visuomotor‐integration processes. Importantly, we show associations between ReHo, cannabis‐use behaviour and execution of complex motor tasks. Given convergent findings in manifest psychotic disorders, this study suggests an HCU endophenotype that may present with a cumulative risk for psychosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional correlates of neurological soft signs in heavy cannabis users

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Both male and female animals were used to examine this relationship, as there are prominent sex differences in age of onset, course of illness, and severity of symptoms in schizophrenia (Gogos et al, 2020 ; Lins et al, 2019 ). In addition, prominent sex‐specific effects have been described in models of MIA (Carney, 2019 ; Gogos et al, 2020 ; Lins et al, 2019 ) and ACE (Borsoi et al, 2019 ; Lee et al, 2014 ; Miladinovic et al, 2020 ; Zamberletti et al, 2012 ), including two‐hit ACE models (Dunn et al, 2020 ). We (Harms et al, 2014 ; Jalewa et al, 2021 ) and others (Astikainen et al, 2011 ; Peter et al, 2010 ; Shiramatsu & Takahashi, 2018 ) have found that incremental/ascending frequency changes between standard and deviant of oddball sequences produce higher MMR amplitude in comparison to decremental/descending frequency changes.…”

Section: Introductionmentioning

confidence: 99%

The effect of schizophrenia risk factors on mismatch responses in a rat model

et al. 2022

View full text Add to dashboard Cite

Reduced mismatch negativity (MMN), a robust finding in schizophrenia, has prompted interest in MMN as a preclinical biomarker of schizophrenia. The rat brain can generate human‐like mismatch responses (MMRs) which therefore enables the exploration of the neurobiology of reduced MMRs. Given epidemiological evidence that two developmental factors, maternal infection and adolescent cannabis use, increase the risk of schizophrenia, we determined the effect of these two developmental risk factors on rat MMR amplitude in different auditory contexts. MMRs were assessed in awake adult male and female Wistar rats that were offspring of pregnant dams treated with either a viral infection mimetic (poly I:C) inducing maternal immune activation (MIA) or saline control. In adolescence, subgroups of the prenatal treatment groups were exposed to either a synthetic cannabinoid (adolescent cannabinoid exposure: ACE) or vehicle. The context under which MMRs were obtained was manipulated by employing two different oddball paradigms, one that manipulated the physical difference between rare and common auditory stimuli, and another that manipulated the probability of the rare stimulus. The design of the multiple stimulus sequences across the two paradigms also allowed an investigation of context on MMRs to two identical stimulus sequences. Male offspring exposed to each of the risk factors for schizophrenia (MIA, ACE or both) showed a reduction in MMR, which was evident only in the probability paradigm, with no effects seen in the physical difference. Our findings highlight the importance of contextual factors induced by paradigm manipulations and sex for modeling schizophrenia‐like MMN impairments in rats.

show abstract