Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease

Testosterone undecanoate improves lipid profile in patients with type 1 diabetes and hypogonadotrophic hypogonadism

“…In patients with type 2 diabetes, reductions in total cholesterol of 15-17 mg/dL with 3-6 months of testosterone administration, associated with a decrease in weight and waist circumference have been observed [6,11]. In the present study, differences from placebo at 22 weeks were 50.6 mg/dL in total cholesterol and 40.7 mg/dL in LDL cholesterol.…”

“…Testosterone replacement therapy in type 2 diabetes patients with hypogonadism produced a significant reduction in insulin resistance and glycosylated hemoglobin [6][7][8] as well as an improvement in anthropometric parameters and a drop in blood pressure [9,10], being controversial the impact on lipid profile [6,7,9,[11][12][13][14].…”

Endogenous sex hormones and subclinical atherosclerosis in middle-aged and older men

“…Alternatively, the absence of an overall association may be indicative of a threshold effect, with low androgens only putting men at risk below a certain level. This hypothesis is supported by results from testosterone supplementation studies showing improvements in vascular function in hypogonadal men [13] and men with a history of cardiovascular disease [14], i.e. men having low testosterone levels.…”

Arteriolar insulin resistance in a rat model of polycystic ovary syndrome

“…A similar but slightly weaker Ca-dependent vasorelaxant effect of E 2 was noted in rat aorta after phenylephrine precontraction (20). Chronic low-dose T administration improved the risk of myocardial ischemia (21), lipid profile, and insulin resistance because of its direct vasoactive and metabolic effects (22). Despite progressive atherosclerosis, chronic T treatment enhanced Ach-dependent, endothelium-dependent relaxation in ovariectomized female monkeys, although it did not influence direct smooth muscle-dependent relaxation elicited by sodium nitroprusside (23).…”