Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking

Dallery, Jesse; Houtsmuller, Elisabeth J.; Pickworth, Wallace B.; Stitzer, Maxine L.

doi:10.1007/s00213-002-1242-8

Cited by 61 publications

(63 citation statements)

References 35 publications

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“…A recent study suggested that the NMR might influence smoking behavior; smokers with higher NMR had greater puff volumes and increased levels of carcinogen biomarker (Strasser et al, 2011). These findings are consistent with previous studies indicating that smokers maintain plasma nicotine levels by adjusting their smoking behavior (Benowitz et al, 1998;Dallery et al, 2003); those with more rapid nicotine clearance would be expected to have greater nicotine intake than those with slower disposition.…”

Section: Introductionsupporting

confidence: 83%

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Sofuoglu

Herman

Nadim

et al. 2012

Neuropsychopharmacol

103

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The ratio of nicotine metabolites (trans-3 0 -hydroxycotinine (3HC) to cotinine) correlates with nicotine clearance. In previous studies, high nicotine metabolite ratio (NMR) predicted poor outcomes for smoking cessation treatment with nicotine patch. The underlying mechanisms that associate NMR with treatment outcomes have not been fully elucidated. A total of 100 smokers were divided into quartiles based on their baseline plasma NMR. Following overnight abstinence, smokers received saline followed by escalating intravenous doses of nicotine (0.5 and 1.0 mg/70 kg) given 30 min apart. The effects of nicotine on subjective, plasma cortisol, heart rate, and systolic and diastolic blood pressure measures were obtained. Smokers in the first NMR quartile (slower metabolizers) had lower Fagerstrom Test for Nicotine Dependence (FTND) scores, suggesting lower levels of dependence. In contrast, smokers in the fourth NMR quartile (faster metabolizers) reported greater craving for cigarettes following overnight abstinence from smoking and reported greater ratings of nicotine-induced good drug effects, drug liking, and wanting more drug. Higher NMR was also associated with greater heart rate increases in response to nicotine. These results suggest that enhanced nicotine reward and cigarette craving may contribute to the poor treatment response in smokers with high NMR. These findings warrant further investigation, especially in treatment-seeking smokers undergoing cessation treatment.

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Section: Introductionsupporting

confidence: 83%

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Sofuoglu

Herman

Nadim

et al. 2012

Neuropsychopharmacol

103

View full text Add to dashboard Cite

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“…In contrast, MEC administration precipitates nicotine withdrawal in nicotine-dependent rodents (Hildebrand et al, 1997;Malin et al, 1994). The finding that MEC did not alter craving and withdrawal suggests that other factors besides nicotine (e.g., tar) may play a role in these subjective effects of cigarette smoking (Dallery et al, 2003;Rose and Behm, 2004).…”

Section: Effect Of Mec Pre-treatment On Smoking Indices and Psychiatrmentioning

confidence: 96%

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

Weinberger

Sacco

Creeden

et al. 2007

Schizophrenia Research

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Background: Schizophrenics have higher rates of smoking than the general population, and more difficulty with smoking cessation. However, there has been little study of differences between schizophrenics and controls with respect to biochemical and behavioral indices of smoking. We compared smokers with schizophrenia (SS; n=27) and control smokers (CS; n=26) on smoking and psychiatric outcomes at baseline, during acute smoking abstinence and reinstatement, and with pretreatment using the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MEC) in a human laboratory setting. Methods:Biochemical (e.g., plasma nicotine) and behavioral (e.g., craving, withdrawal) outcomes were assessed at baseline, after overnight abstinence, and after smoking reinstatement during three consecutive test weeks. Each week, participants received one of three doses of MEC (0.0, 5.0, or 10.0 mg/day × 3 days) in a randomized, counterbalanced manner.

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“…receiving cues alone) produces comparable levels of smoke intake, satisfaction, and reduction of craving and withdrawal as smoking nicotine-containing cigarettes (i.e. cues plus nicotine) (Gross et al 1997;Shahan et al 1999;Rose et al 2000;Shahan et al 2001;Dallery et al 2003). Similarly, the removal of visual and olfactory cues associated with cigarettes reduce overall measures of reinforcement derived from smoking ).…”

Section: Implications For Smokingmentioning

confidence: 99%

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

et al. 2005

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Although considerable progress has been made we do not yet fully understand the behavioral and neurobiological bases of nicotine reinforcement, and without this knowledge treatment strategies aimed at reducing smoking remain deficient. This dissertation provides an original perspective on nicotine reinforcement, which arises from substantial evidence of complex interactions between nicotine and nonpharmacological stimuli. The present experiments tested the hypothesis that nicotine reinforcement derives from at least two sources: 1) the primary reinforcing properties of nicotine, an action that requires response-dependent drug administration, and 2) the more prominent ability of nicotine to enhance behavior maintained by salient non-nicotine stimuli, an action that does not require a contingent relationship between drug administration and reinforced operant responding. Although novel for nicotine, this hypothesis has origins in an extensive literature on the reinforcing properties of psychostimulant drugs. Empirical support for the application of this hypothesis to nicotine reinforcement will be presented. By investigating the interaction between nicotine and nonpharmacological stimuli within the context of drug selfadministration in rats, the present research has generated new insights into the paradox of how nicotine, an apparently weak primary reinforcer, can sustain the robust behavior observed in selfadministration and in smoking. Hypotheses generated by these data provide important direction for future investigations into the neurobiology of nicotine reinforcement.iii

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Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking

Cited by 61 publications

References 35 publications

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia

Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement

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