Effects of cigarette smoking on blood lipids in Korean men: Cardiovascular and Metabolic Diseases Etiology Research Center cohort

Kim, Sang-Yong; Kim, Hyeon Chang; Shim, Jee Seon; Kim, Dae Jung

doi:10.3904/kjim.2019.133

Cited by 16 publications

(14 citation statements)

References 49 publications

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“…The significance of smoking and tobacco use in the onset of disordered lipid profile, [38][39][40] CVD risks, 7,41,42 and mortality 3,43 has been well documented in the literature. For example, active smoking and tobacco use have been associated with elevated triglycerides, 39 myocardial injury, 42 and vascular diseases 41 among others. However, the contribution(s) of SHSE, particularly among non-smokers, is yet to be well documented.…”

Section: Discussionmentioning

confidence: 99%

Secondhand smoke exposure and dyslipidemia among non‐smoking adults in the United States

et al. 2021

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Dyslipidemia represents a constellation of disorders in lipid metabolism 1 and is often characterized by elevated levels of total cholesterol (TC) or triglycerides (TG) or low-density lipoprotein (LDL) and/or lower levels of high-density lipoprotein (HDL). It is a risk factor for cardiovascular diseases (CVD) 2 and one of the largest contributors to disability-adjusted life-years (DALYs) globally 3 with a compelling increase in the cost of care. 4

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Section: Discussionmentioning

confidence: 99%

Secondhand smoke exposure and dyslipidemia among non‐smoking adults in the United States

et al. 2021

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“…M0 macrophages were reported to be inversely associated with patients' outcomes in various, such as adrenal cortical carcinoma and lung cancer [46,47]. Nowadays, majority studies evaluated the degree of smoking based on the frequency of tobacco use to define heavy smokers and light smokers without uniform quantifying standards [48][49][50]. Moreover, these cut-offs cannot accurately identify the true degree of smoking because they do not comprehensively consider the DNA damage and microenvironment alteration.…”

Section: Discussionmentioning

confidence: 99%

The benefits of smoking cessation on survival in cancer patients by integrative analysis of multi‐omics data

2020

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Few studies have examined the association between smoking status (including former smokers) at diagnosis and overall survival among cancer patients. We aimed to assess the benefits of quitting smoking on cancer prognosis in cohorts of cancer patient smokers obtained from the Cancer Genome Atlas (TCGA) database. Hazard ratios (HR) were calculated to evaluate smoking behavior at cancer diagnosis (reformed smokers vs. current smokers) in association with overall survival using multivariate‐adjusted Cox regressions analysis. According to our analyses, quitting smoking was the independent protective factor for overall survival in lung squamous cell carcinoma (LUSC) (HR = 0.67, 95% CI = 0.48–0.94). Comprehensive analysis of multicomponent data across reformed and current smokers identified a total of 85 differential expressed genes (DEGs) affected by different modes of genetic and epigenetic regulation, potentially representing cancer drivers in smokers. Moreover, we provided a smoking‐associated gene expression signature, which could evaluate the true effect on prognosis with high power (HR = 1.70, 95% CI = 1.19–2.43, AUC = 0.65, 0.67, and 0.70 for 2‐, 3‐, and 5‐year survival, respectively). This signature was also applicable in other smoking‐related cancers, including bladder urothelial carcinoma (HR = 1.70, 95% CI = 1.01–2.88), cervical carcinoma (HR = 5.69, 95% CI = 1.37–23.69), head and neck squamous cell carcinoma (HR = 1.97, 95% CI = 1.41–2.76), lung adenocarcinoma (HR = 1.73, 95% CI = 1.16–2.57), and pancreatic adenocarcinoma (HR = 4.28, 95% CI = 1.47–12.47). In conclusion, this study demonstrates that quitting smoking at diagnosis decreases risk of death in cancer patients. We also provide a smoking‐associated gene expression signature to evaluate the effect of smoking on survival. Lastly, we suggest that smoking cessation could comprise a part of cancer treatment to improve survival rates of cancer patients.

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“…Cigarette smoking is a known behavioral risk factor for hypertriglyceridemia [25][26][27]. We found that the prevalence of hypertriglyceridemia among current smokers, especially among regular current smokers, was higher when compared with those who never smoked.…”

Section: Discussionmentioning

confidence: 78%

Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021

et al. 2022

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Background Hypertriglyceridemia is a common health problem independently associated with an increased risk of atherosclerosis cardiovascular diseases (ASCVD), including ischemic heart disease and stroke. This study aims to determine the prevalence of hypertriglyceridemia among Royal Thai Army (RTA) personnel and its behavioral and cardiometabolic risk factors using the RTA personnel database of the physical health examination from 2017 to 2021. Methods A serial cross-sectional study was conducted from 2017 to 2021. A total of 257,683 active-duty RTA personnel aged 35–60 years were included in the study. We defined hypertriglyceridemia as fasting triglyceride ≥150 mg/dL. Moreover, we performed a multivariable logistic regression analysis to investigate behavioral and cardiometabolic risk factors for the prevalence of hypertriglyceridemia. The magnitude of the association was presented as an adjusted odds ratio (AOR) with a 95% confidence interval (CI). Results The hypertriglyceridemia prevalence among RTA personnel was 43.4% (95% CI: 42.9–43.8%) in 2017. It then continuously decreased to 40.3% (95% CI: 39.9–40.7%) in 2020 and slightly rose to 41.0% (95% CI: 40.6–41.4%) in 2021 (p for trend < 0.001). The prevalence of hypertriglyceridemia was higher for males than females (AOR 2.15; 95% CI: 2.07–2.23); RTA personnel aged 40–44 years compared with those aged 35–39 years (AOR 1.05; 95% CI: 1.02–1.08); and RTA personnel residing in the northeast (AOR; 1.15 95% CI: 1.11–1.18) and the north (AOR 1.05; 95% CI: 1.02–1.08) compared with those residing in Bangkok. The independent behavioral factors associated with hypertriglyceridemia included alcohol consumption, smoking, and sedentary behavior. Moreover, cardiometabolic risk factors, including higher body mass index, high fasting plasma glucose (≥ 100 mg/dL), high blood pressure (≥ 140/90 mmHg), and hypercholesterolemia (≥ 200 mg/dL), were significantly related to hypertriglyceridemia. Conclusion Our data demonstrated that hypertriglyceridemia is a frequent health issue, especially among males, participants aged 40–44 years, and RTA personnel residing in the northeast and the north. The prevalence of hypertriglyceridemia in this population was greatly influenced by alcohol consumption, cigarette smoking, and sedentary behavior. Both behavioral and cardiometabolic risk factors are potential targets for intervention to enhance the primary prevention of sequelae of hypertriglyceridemia, including ASCVD.

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Effects of cigarette smoking on blood lipids in Korean men: Cardiovascular and Metabolic Diseases Etiology Research Center cohort

Cited by 16 publications

References 49 publications

Secondhand smoke exposure and dyslipidemia among non‐smoking adults in the United States

Secondhand smoke exposure and dyslipidemia among non‐smoking adults in the United States

The benefits of smoking cessation on survival in cancer patients by integrative analysis of multi‐omics data

Prevalence of hypertriglyceridemia among Royal Thai Army personnel and its related cardiometabolic risk factors, from 2017 to 2021

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