Effects of Cigarette Smoking on Heart Rate Variability and Plasma N‐Terminal Pro‐B‐Type Natriuretic Peptide in Healthy Subjects: Is There the Relationship between Both Markers?

Abstract

These findings could contribute to the higher rate of cardiovascular events in smokers.

Autonomic Dysfunction in Current Cigarette Smokers Assessed by Time Series Analysis of Heart Rate Variability

“…4,11 In the present study, lower cardiac vagal modulation supported by lower values of time domain measures agrees various other investigators. 11,12,13,14 Also, the significantly lower mean R-R interval in all smokers compared to non smokers were comparable to the findings of Barutcu et al 15 The reduced cardiac vagal modulaion and the simultaneous sympathetic hyperactivity in the smokers of this study may be the effect of consumption of nicotine and other substances contained in cigarette smoke and this view is shared by several groups of researchers. 4,11,12,[15][16][17] In smokers, the higher value of mean heart rate indicates higher sympathetic and lower values of mean R-R interval, SDNN and RMSSD indicates lower parasympathetic activity.…”

“…As a major component of cigarette smoke, nicotine stimulates the nicotinic receptors of autonomic ganglia as well as adrenal medulla resulting in increased cardiac sympathetic activity and increased release of catecholamine. 12,[18][19] This effect is obviously attributed to the higher heart rate and the restriction of heart rate variability in the smokers of this study. This effect of nicotine may be further intensified by its action on peripheral chemoreceptors causing impaired baroreflex sensitivity.…”

Comparação Da Modulação Autonômica Cardíaca Durante Esforço De Fumantes E Não Fumantes

“…Alyan et al 28 avaliaram os efeitos do tabaco na VFC entre adultos jovens (cerca de 35 anos), fumantes e não fumantes de ambos os sexos, e observaram uma redução nos índices rMSSD e AF.…”

Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

“…Further, smoking cessation ameliorates these conditions. The studied by Omer et al 7 with 75 healthy habitual smokers (40 females, 35 males, mean age 36.5 ± 8.5 years), and 73 nonsmokers (45 females, 28 males, mean age 34.6 ± 7.2 years). Additionally, found that smoking resulted in an increase NT-pro-BNP levels and there was a significant positive correlation observed between the duration of smoking and NT-pro-BNP levels.…”

“…6 Studies have reported usefulness of measurement of plasma BNP levels as a biomarker for the detection and follow-up of heart diseases and a risk factor for death independent of COPD. 6,7 Studies related to BNP levels in Stable COPD patients without PH or COR-P however, are limited. 2,8,9 The aim of the present study was to investigate the use of plasma BNP levels as a prognostic marker in patients with stable COPD during exacerbation and after remission.…”