Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Gupta, Nidhi; Vanane, Jignesh; Dubey, Gajendra; Varmore, Ravi; Garg, Pankaj

doi:10.18410/jebmh/2018/401

jebmh

2018

DOI: 10.18410/jebmh/2018/401

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Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Nidhi Gupta¹,

Jignesh Vanane²,

Gajendra Dubey³

et al.

Abstract: BACKGROUNDIt has long been known that pulmonary hypertension (PH) leads to rise in brain natriuretic peptide (BNP) in patients with Chronic Obstructive Pulmonary Disease (COPD). However, data on BNP level in COPD patients without PH is limited. This study was carried out to evaluate the change in BNP level in COPD patients without PH or cor-pulmonale during exacerbation and after remission.

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Cited by 2 publications

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Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Bodrug

Luca

2022

Egypt J Bronchol

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Background Natriuretic peptides (NPs) are considered a useful tool for diagnosing the cardiac or pulmonary origin of acute dyspnea in the emergency department. The aim of this study was to evaluate NP in elderly patients with chronic obstructive pulmonary disease (COPD). Materials and methods In the PubMed and Hinari databases, we identified 465 comprehensive articles in English, published in the years 1990–2021, which provided information on natriuretic peptides in elderly patients with COPD. The final bibliography contains 49 relevant sources. Results NP, specially BNP/NT-proBNP values are frequently elevated in patients with COPD, reflecting three complex aspects of the interrelated cardio-pulmonary continuum: (1) left ventricular systolic and diastolic dysfunction, (2) pulmonary vascular and right heart remodeling, (3) global cardiovascular risk and comorbidities. The additional increase in BNP/NT-proBNP values during acute exacerbation of COPD is probably a marker for both, acute estate of COPD and varying degrees of underlying cardiopulmonary disease. The results of the studies suggest the role of natriuretic peptides as relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with chronic obstructive pulmonary disease, which has an important clinical implication. The determination of these biomarkers in patients with chronic obstructive pulmonary disease allows stratification for prognosis: it is able to select a subgroup of patients at higher risk, which requires increased attention and optimization of treatment. Conclusion NPs, especially BNP/NT-proBNP are relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with COPD, acute exacerbations and haemodynamic disorders like PH and cor pulmonale. Estimating BNP/NT-proBNP in COPD patients has an important clinical implication: it allows the selection of a subgroup of patients at higher risk, which requires increased attention and treatment optimization.

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Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Bodrug

Luca

2022

Egypt J Bronchol

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Brain Natriuretic Peptide in Patients with Acromegaly: A Comparative Study between those with and without Obstructive Sleep Apnea

Hammood,

Ali,

Rahmah

2024

Mustansiriya Medical Journal

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Background: Acromegaly is a rare endocrine disorder; it has an incidence of 4 per million annually and a prevalence of 40 per million. It is due to growth hormone-secreting pituitary adenoma. The objective of our study is to evaluate the levels of brain natriuretic peptide (BNP) in patients with acromegaly with and without obstructive sleep apnea (OSA). Materials and Methods: One hundred five registered patients with acromegaly in the National Diabetes Center-Mustansiriyah University were enrolled in the study. Out of 105 patients with acromegaly, 81 have OSA while the remaining 24 have no OSA. OSA affects 81.8% of males and 72% of females. All recruited patients have given oral consent to participate in the study which was conducted during the period from January to October 2023. Results: Males with OSA had a mean age of 52 years while those without OSA had a mean age of 46 years. Epworth Sleepiness Scale is higher among those with OSA. BNP is found to be higher in females with OSA (905.54 pg/ml) while in males with OSA, it drops down to 878.76 pg/ml. In no OSA group, the BNP level was 355.33 ± 30.1 pg/ml while in those with OSA, it jumped to 890.66 ± 205.63 pg/ml. Conclusions: The results showed that BNP was elevated in patients with acromegaly and OSA versus those without OSA, OSA is more common in males particularly when they get older.

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Plasma Brain Natriuretic Peptide Levels in Chronic Obstructive Pulmonary Disease Patients Without Pulmonary Hypertension

Cited by 2 publications

References 13 publications

Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease

Brain Natriuretic Peptide in Patients with Acromegaly: A Comparative Study between those with and without Obstructive Sleep Apnea

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