“…7,8 Accumulated experience indicates that it is a useful, albeit underutilized, agent for both coronary (CAD) and peripheral artery disease (PAD), particularly for patients undergoing percutaneous revascularization; it also has similar or greater efficacy and safety profiles vs conventional antiplatelet agents for secondary prevention of stroke, while it constitutes an alternative in those who are allergic or intolerant to classical antithrombotic agents, such as aspirin or clopidogrel. [9][10][11][12][13][14] A comprehensive review of the literature was undertaken, and the results of studies involving the use of cilostazol in patients with cardiovascular disease (CVD), including CAD, PAD, and stroke, managed medically or with percutaneous revascularization, are discussed, including current guidelines; metaanalyses are tabulated, and the span of cilostazol's actions and therapeutic applications is pictorially illustrated (Tables 1-4, Figures 1-3). To conduct this review, all titles and abstracts of papers containing the term cilostazol were reviewed in the PubMed, Scopus, and Google Scholar, and full articles were retrieved and reviewed that were relevant to our objectives of pharmacological properties of the drug; its pharmacokinetics/pharmacodynamics; antithrombotic, antiplatelet/platelet-inhibitory, and cardiovascular (CV)/hemodynamic actions; metabolic actions; clinical effects/applications; side effects/safety; and CAD, PAD, stroke, and percutaneous procedures.…”