Effects of Clomid and Sexovid on FSH and LH Secretion in Mature Female Rats

Gonadotrophin Release in Ovariectomized Patients

“…There is still a considerable degree of uncertainty about the exact mode of action of clomiphene (1 -[p-0-diethyl-aminoethoxyphenyl] -1,2,diphenyl-2 chloroethylene citrate) a nonsteroidal oestrogen antagonist. However, it appears increasingly evident that this compound which possesses antioestrogenic properties acts probably in an indirect manner, by competing with oestradiol for the receptor sites at the hypothalamic centres regulating gonadotrophin secretion, thus stimulating gonadotrophin releasing hormone (LHRH) secretion, with a subsequent release of FSH and LH (Igarashi et al, 1967;Seki et al, 1970).…”

“…In view of our findings, it seems as if the ability of anovulatory patients to respond to clomiphene treatment by increased gonadotrophin secretion depends upon the absolute concentration of the compound in the different organs and by the quantitative relation of clomiphene to the endogenous oestrogens.There is still a considerable degree of uncertainty about the exact mode of action of clomiphene (1 -[p-0-diethyl-aminoethoxyphenyl] -1,2,diphenyl-2 chloroethylene citrate) a nonsteroidal oestrogen antagonist. However, it appears increasingly evident that this compound which possesses antioestrogenic properties acts probably in an indirect manner, by competing with oestradiol for the receptor sites at the hypothalamic centres regulating gonadotrophin secretion, thus stimulating gonadotrophin releasing hormone (LHRH) secretion, with a subsequent release of FSH and LH (Igarashi et al, 1967;Seki et al, 1970).By contrast, in prepubertal children, a paradoxical suppression of both LH and FSH release was demonstrated following administration of clomiphene (Kelch et al, 197 1). The explanation offered for this phenomenon was that the immature hypothalamic gonadostat…”