Effects of Cnidoscolus aconitifolius on Some Hematological Parameters of Male Wistar Rats

Abstract

Introduction: Medicinal plants have become increasingly useful as a form of alternative therapy. Cnidoscolus aconitifolius is a medicinal plant applied in folklore remedies in the treatment and prevention of various diseases.
 Aim: The aim of this study is to assess the effects of Cnidoscolus aconitifolius on some hematological parameters of male Wistar rats.
 Methodology: A total of 15 male Wistar rats weighing between 100-250 g were randomly placed in groups. Group 1 served as control and received distilled water only; group 2 received 200 mg/kg and group 3 received 400 mg/kg of the hydromethanolic leaf extract of Cnidoscolus aconitifolius. Extract was administered once daily using oro-gastric cannula for 30 days. Blood samples were collected by direct cardiac puncture into appropriate sample tubes for estimation of hematological parameters including red blood cell count (RBC), packed cell volume (PCV), haemoglobin (Hb) concentration, white blood cell count (WBC) and platelet count.
 Results: Results showed a significant (P<0.05) increase in RBC, PCV, Hb and platelet count with the higher dose of 400 mg/kg body weight of the extract compared to control group. However, the WBC count was not significantly (P>0.05) altered.
 Conclusion: Oral administration of the leaf extract of Cnidoscolus aconitifolius increases red blood cell count, packed cell volume, hemoglobin level and platelet count at 400 mg/kg body weight.

The Effects of the Aqueous, Ethanol and Hexane Extracts of Cnidoscolus aconitifolius Leaf on the Hematological Indices and Liver Histological Status of Streptozotocin-induced Diabetic Rats

“…Alloxan-treated rats with Cnidoscolus aconitifolius significantly increased PCV, RBC, Hb, WBC, and MCV with corresponding increase in the platelet values (Azeez et al, 2010). Similar result was replicated by Ezebuiro et al (2020) at a high dose of 400mg/kg of Cnidoscolus aconitifolius. Currently as depicted from this results of Cnidoscolus aconitifolius on haematological parameters in STZinduced diabetic rats showed a significant (P<0.05) increase in the Hb, PCV, and TRBC levels when compared with the diabetic group.…”

“…DM individuals are predisposed to developing retinopathy, nephropathy and neuropathy (microvascular complications) and cardiovascular comorbidities (macrovascular complications) as a result of hyperglycaemia and metabolic syndrome (Defronzo et al, 2015). However, the associated insulin resistance and impeded insulin secretion determines the kind of anti-diabetic agents required to maintain normoglycaemia (Ezebuiro et al, 2020). Over time, novel medications have being designed and developed, but the highest priority is based on the production of agents that can improve insulin sensitivity, pause the advancement of pancreatic β-cell failure and reverse, prevents or blocks the macrovascular and microvascular complications associated with DM (Chawla et al, 2016 ).…”